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| 1 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis显示文摘 | McVeigh GE Allen PB Morgan DR | 2001 | Clin Sci2001，100，： | 1 |
| 3 | Electrical and mechanical effects of BRL 34915 in guineapig isolated trachealis显示文摘 | Allen SL Boyle JP Cortijo J Foster RW Morgan GP Small RC | 1986 | Br J Pharmacol1986，89，： | 1 |
| 4 | Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis显示文摘 | McVeigh GE Allen PB Morgan DR | 2001 | Clin Sci (Lond)2001，100，4： | 1 |
| 5 | Effects of biomass growth on gas pressure drop in biofilters显示文摘 | Morgan - Sagastume F Sleep BE Allen DG | | 0，，05： | 1 |
| 6 | Early events in stretch - induced muscle dam-age显示文摘 | Morgan DLA Allen DG | 1999 | J APPI Physiol1999，87，6： | 1 |
| 7 | A quantitative analysis of the effects of nitrogen on the growth,development and yield of oilseed rape显示文摘 | ALLEN E J MORGAN DG | 1972 | The Journal of Agricultural Science1972，78，2： | 1 |
| 8 | The relaxant action of nicorandil in guinea-pig isolated trachealis显示文摘 | ALLEN S L FOSTER R W MORGAN G P | 1996 | Br J Pharmacol1996，87，1： | 1 |
| 9 | Experimental and theoretical evaluation of microbubble behavior: Effect of transmitted phase and bubble size显示文摘 | Allen JS Dayton PA | 2000 | IEEE Trans Ultrason Ferroelect Freq Control2000，47，： | 1 |
| 10 | Ex vivo canine lens capsular sac explants显示文摘 | M. G. Davidson M. Wormstone D. Morgan R. Malakof J. Allen M. C. McGahan | 2000 | Graefe’s Archive for Clinical and Experimental Ophthalmology2000，，8： | 1 |
| 11 | Experimental and theoretical evaluation of microbubble behavior:effect of transmitted phase and bubble size显示文摘 | Morgan KE Allen JS Dayton PA | 2000 | IEEE Trans Ultrason Ferroelec Freq Control2000，47，6： | 1 |
| 12 | Suicidal Behavior, Negative Affect, Gender, and Self- Reported Delinquency in College Students 显示文摘 | Jennifer Langhinrichsen-Rohling Catalina Arata David Bowers Natalie O' Brien Allen Morgan | 2004 | Suicide & Life : Threatening Behavior2004，34，3： | 1 |
| 13 | Abnomal intracellular calcium handing, a major cause of systolic and diastolic dysfunction on ventrieular myocardium from patients with heart failure 显示文摘 | Morgan JP Erny RE Allen PD | 1990 | Circulation1990，81，2： | 1 |
| 14 | Abnormal intracellular calcium handling,a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure显示文摘 | Morgan JP Erny RE Allen PD | 1990 | Circulation1990，81，2： | 1 |
| 15 | Nitric oxide modulation of blood vessel tone identified by arterial waveform analysis显示文摘 | McVeigh GE Allen PB Morgan DR | 2001 | Clin Sci2001，100，： | 1 |
| 16 | Abnormal intracellular calcium handlung, a major cause of systolic and diastolic dys function in ventricular myocardium from patients with heart ;failure显示文摘 | Morgan JP Emy RE Allen PD | 1990 | Circulation1990，81，2： | 1 |
| 17 | Experimental and theoretical evaluation of microbubble behavior:effect of transmitted phase and bubble size显示文摘 | Morgan K E Allen J S Dayton P A | 2000 | IEEE Trans on UFFC2000，47，6： | 1 |
| 18 | The deliberate search for the stratigraphic trap : an introduction 显示文摘 | Allen M R Goffey G R Morgan R K | 2006 | Geological Society2006，254，： | 1 |
| 19 | Early events in stretch-induced muscle damage显示文摘 | Morgan DL Allen DG | 1999 | J Appl Physiol1999，87，6： | 1 |
| 20 | Leaf photosynthesis and carbohydrate dynamics of soybeans grown throughout their life-cycle under free-air carbon dioxide enrichment显示文摘 | Rogers A Allen D J Davey P A Morgan P B Ainsworth E A Bernacchi C J Cornic G Dermody O Dohleman F G Heaton E A Mahoney J Zhu X G Delucia E H Ort D R Long S P | 2004 | Plant cell Environ2004，27，： | 1 |
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