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| 1 | Intestinal anti-inflammatory activity of Ground Cherry(Physalis angulata L.)standardized CO2 phytopharmaceutical preparation显示文摘AIM To investigate the effects of Ground Cherry(Physalis angulata L.)standardized supercritical CO_2 extract in trinitrobenzenesulphonic acid(TNBS)model of rat intestinal inflammation.METHODS The animals were divided into groups that received vehicle or P.angulata extract(PACO_2)orally at the doses 25,50 and 100 mg/kg daily by 5 d before TNBS damage.Protective effects of PACO_2 were assessed by macroscopic analysis,biochemical determinations of the levels of myeloperoxidase(MPO),alkaline phosphatase(ALP),glutathione and cytokines(such as INF-γ,IL-1β,IL-6,IL-10 and TNF-α),gene expression evaluation(including Hsp70,heparanase,NF-κB,mitogenactivated protein kinases(Mapk)1,3,6 and 9,and the mucins genes Muc 1,2,3 and 4)and histopathological studies using optical,and electronic(transmission and scanning)microscopy.RESULTS PACO2 extract promoted a significant reduction in MPO and ALP activities,reducing oxidative stress and neutrophil infiltration.These effects were accompanied by significant reduction of colonic levels of IFN-γand IL-6 and down-regulation of heparanase,Hsp70,Mapk3,Mapk9,Muc1 and Muc2 genes expression when compared with TNBS-control animals.In addition,protective effects were also evidenced by reduced neutrophil infiltration,recovery of cell architecture and replacement of mucin by histopathological and ultrastructural analysis.CONCLUSION Physalis angulata supercritical CO2 extract is an intestinal anti-inflammatory product that modulates oxidative stress,immune response and expression of inflammatory mediators,with potentially utility for treating inflammatory bowel disease. | luiz domingues almeida junior ana elisa valencise quaglio celso acácio rodrigues de almeida costa Luiz Claudio Di Stasi | 2017 | World Journal of Gastroenterology2017，23，24： | 4 |
| 2 | 原因不明的脑卒中患者心房纤维化增加:心脏磁共振成像研究显示文摘一些被归类为原因不明的缺血性脑卒中患者可能有左心房和左心耳结构或功能的改变,增加了他们的血栓栓塞风险。该研究使用心脏磁共振成像比较不同病因的缺血性脑卒中患者的左心房和左心耳结构及功能。研究人员前瞻性连续纳入缺血性脑卒中患者样本。 | 刘莉 叶鹏 Fonseca AC Alves P Inácio N Marto JP Viana-Baptista M Pinho-E-Melo T Ferro JM Almeida AG | 2018 | 中华高血压杂志2018，26，3： | 2 |
| 3 | The effect of nitrous oxide on the inhibition of somatosensory evoked potentials by sevoflurane in children显示文摘 | da Costa VV Saraiva RA de Almeida AC | 2001 | Anesthesia2001，56，3： | 1 |
| 4 | Bilateral optic neuropathy associated with cryptococcal meningitis in an immunoeompetent patient 显示文摘 | Portelinha J Passarinho MP Almeida AC | 2014 | BMJ Case Rep2014，6，11： | 1 |
| 5 | Alanine aminotransferase and high sensitivity C-reactive protein:correlates of cardiovascular risk factors in youth显示文摘 | Oliveira AC Oliveira AM Almeida MS | 2008 | J Pediatr2008，152，3： | 1 |
| 6 | Impact of stroke unit in a public hospital on length of hospitalization and rate of early mortality of ischemic strokepatients显示文摘 | Rocha MS Almeida AC Abath Neto O | | 0，，10： | 1 |
| 7 | Finite element stress analysis of edentulous mandibles with different bone types supporting multiple-implant super-structures显示文摘 | de Almeida EO Rocha EP Freitas AC JR | 2010 | Int J Oral Maxil- lofac Implants2010，25，6： | 1 |
| 8 | Prevalence,risk factors,and epidemiology of methicillin-resistantStaphylococcus aureus carried by adults over 60 years of age显示文摘 | Almeida ST Nunes S Paulo AC | 2015 | Eur J Clin Microbiol Infect Dis2015，34，3： | 1 |
| 9 | Cerebellopontine angle subependymoma without fourth ventricle extension:an uncommon tumor in a rare location显示文摘 | Cunha AM Brito AC de Almeida Lima G | 2012 | Neuropathology2012，32，2： | 1 |
| 10 | Hearing loss in aging显示文摘 | Baraldi Gdos S de Almeida LC Borges AC | 2007 | Braz J Otorhinolaryngol2007，73，： | 1 |
| 11 | Effects of anterior thalamic nucleus deep brain stimulation in chronic epileptic rats显示文摘 | Covolan L de Almeida AC Amorim B | 2014 | PLoS One2014，9，97： | 1 |
| 12 | Poland-Moebius syndrome:a case with oral anomalies显示文摘 | Domingos AC Lopes SL Almeida SM | 2004 | Oral Dis2004，10，6： | 1 |
| 13 | Surgical treatment of acute type B aortic dissection using an endoprosthesis(elephant trunk)显示文摘 | Palma JH Almeida DR Carvalho AC | 1997 | Ann Thorac Surg1997，63，5： | 1 |
| 14 | Sleep deprivation reduces total plasma homocysteine levels in rats显示文摘 | de Oliveria AC Almeida VD Hipolide DC | 2002 | Canadian J Physio and Pharmacology2002，80，3： | 1 |
| 15 | Data envelopment analysis for evaluating publichospitals in Brazilian state capitals 显示文摘 | Goncalves AC Noronha CP Lins MP Almeida RM | 2007 | Rev Saude Pub- lica2007，41，3： | 1 |
| 16 | Adherence to tyro- sine kinase inhibitor therapy for chronic myeloid leukemia:a Brazil- ian single-center cohort 显示文摘 | de Almeida MH Pagnano KB Vigorito AC | 2013 | Acta Haematol2013，130，： | 1 |
| 17 | Long-term stability of an anterior open-bite malocclusion treated in the mixed dentition 显示文摘 | de Almeida MR de Almeida RR Conti AC | 2006 | J Appl Oral Sci2006，14，6： | 1 |
| 18 | Pregnancy after heart transplantation显示文摘 | Almeida DR Carvalho AC Branco JN | 1995 | Arq Brasi Cardiol1995，65，3： | 1 |
| 19 | Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat显示文摘 | de-Faria FM Almeida AC Luiz-Ferreira A | | 0，，： | 1 |
| 20 | Finite element stress analysis of edentulous mandibles with different bone types supporting muhiple-implant superstructures 显示文摘 | de Almeida EO Rocha EP Freitas AC Jr | 2010 | Int J Oral Max- illofac Implants2010，25，6： | 1 |
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