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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Children in Disaster Risk Reduction in Portugal: Policies,Education,and (Non) Participation显示文摘International agencies and scientific research have been calling for the inclusion of children in disaster preparedness and risk reduction, to hear their voices in order to address their specific needs and vulnerabilities and harness their capabilities in terms of building community resilience. This article assesses the roles ascribed to children in policy and education for disaster risk reduction in Portugal. The approach is based on a scoping methodology that encompasses document analysis and interviews with national and local stakeholders and policymakers in the disaster risk reduction field. The research is carried out within the scope of a European funded project, CUIDAR Cultures of Disaster Resilience among Children and Young People. More specifically, the article provides an overview of the discourses on the roles ascribed to children in urban disaster risk reduction(DRR). The authors maintain that although children are often taken as a target group in urban disaster prevention and management, they are seldom considered in terms of active participation in disaster risk reduction programs in the Portuguese context. Nevertheless, our analysis shows that there is a growing awareness of the relevance of active participation by children in order to create successful DRR. | Ana Delicado ussara Rowland Susana Fonseca Ana Nunes de Almeida Luísa Schmidt Ana Sofia Ribeiro | 2017 | International Journal of Disaster Risk Science2017，8，3： | 2 |
| 3 | Short versions of the geriatric depression scale: a study of their validity for the diagnosis of a major depressive episode according to ICD-10 and DSM-IV显示文摘 | Almeida OP Almeida SA | 1999 | Int J Geriatr Psychiatry1999，14，： | 1 |
| 4 | Value of 18F-FDG-PET/CT as a predictor of cancer in solitary pulmonary nodule显示文摘 | Martins Rde C Almeida SA Siciliano AA | 2008 | Bras Pneumol2008，34，7： | 1 |
| 5 | Natriiiretic peptide clearance receptor ligand(C-ANP(4-23)attenuates angiogenesis in a murine sponge implant model显示文摘 | Almeida SA Cardoso CC OreIIano LA | 2014 | Clin Exp Pharmacol Physiol2014，6，： | 1 |
| 6 | Leishmania chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage显示文摘 | DE ALMEIDA MC CARDOSO SA BARRAL M | 2003 | Int Parasitol2003，33，2： | 1 |
| 7 | Short versions of the geriatric depression scale:a study of their validity for the diagnosis of a major depressive episode according to ICD-10 and DSM- IV 显示文摘 | Almeida OP Almeida SA | 1999 | International Journal of Geriatric Psychiatry1999，，： | 1 |
| 8 | Delivery assistance in fetal microsomia 显示文摘 | Auguusto Moreira de sa R Guerious Bornia RB de Almeida Cunha A | 2003 | Rev Bras Saude Matem Infant2003，3，4： | 1 |
| 9 | Value of 18F-FDG-PET/CT as a predictor of cancer in solitary pulmonary nodule显示文摘 | Martins RC Almeida SA Siciliano AA | | 0，，04： | 1 |
| 10 | Human dental pulp cells:a new source of cell therapy in a mouse of compressive spinal cord injury显示文摘 | de Almeida FM Marques SA Ramalho Bdos S | 2011 | J Neurotrauma2011，28，9： | 1 |
| 11 | A rapid assessment methodology for the evaluation of primary care organization and performance in Brazil 显示文摘 | Macinko J Almeida C De Sa PK | 2007 | Health Policy Plan2007，22，3： | 1 |
| 12 | Lower sex hormone binding globulin is more strongly associated with metabolic syndrome than lower total testosterone in older men:the Health in Men Study 显示文摘 | Chubb SA Hyde Z Almeida OP | 2008 | Eur J Endocrinol2008，158，6： | 1 |
| 13 | Human dental pulp cells: a new source of cell therapy in a mouse model of compressive spinal cord injury 显示文摘 | de Almeida FM Marques SA Ramalho Bdos S | 2011 | J Neurotrauma2011，28，9： | 1 |
| 14 | Metabolomics in chronic hepatitis C:Decoding fibrosis grading and underlying pathways显示文摘BACKGROUND Chronic Hepatitis C(CHC)affects 71 million people globally and leads to liver issues such as fibrosis,cirrhosis,cancer,and death.A better understanding and prognosis of liver involvement are vital to reduce morbidity and mortality.The accurate identification of the fibrosis stage is crucial for making treatment decisions and predicting outcomes.Tests used to grade fibrosis include histological analysis and imaging but have limitations.Blood markers such as molecular biomarkers can offer valuable insights into fibrosis.AIM To identify potential biomarkers that might stratify these lesions and add information about the molecular mechanisms involved in the disease.METHODS Plasma samples were collected from 46 patients with hepatitis C and classified into fibrosis grades F1(n=13),F2(n=12),F3(n=6),and F4(n=15).To ensure that the identified biomarkers were exclusive to liver lesions(CHC fibrosis),healthy volunteer participants(n=50)were also included.An untargeted metabolomic technique was used to analyze the plasma metabolites using mass spectrometry and database verification.Statistical analyses were performed to identify differential biomarkers among groups.RESULTS Six differential metabolites were identified in each grade of fibrosis.This six-metabolite profile was able to establish a clustering tendency in patients with the same grade of fibrosis;thus,they showed greater efficiency in discriminating grades.CONCLUSION This study suggests that some of the observed biomarkers,once validated,have the potential to be applied as prognostic biomarkers.Furthermore,it suggests that liquid biopsy analyses of plasma metabolites are a good source of molecular biomarkers capable of stratifying patients with CHC according to fibrosis grade. | Adriana Camargo Ferrasi Samara Vitória Granja Lima Aline Faria Galvani Jeany Delafiori Flavia Luísa Dias-Audibert Rodrigo Ramos Catharino Giovanni Faria Silva Roberta Rodrigues Praxedes Driele Bretones Santos Dayane Trevisan de Macedo Almeida Estela Oliveira Lima | 2023 | World Journal of Hepatology2023，15，11： | 1 |
| 15 | Oral immunization with attenuated Salmonella vaccine expressing Escherichia coli O157 :H7 intimin gamma triggers both systemic and mucosal humoral immunity in mice 显示文摘 | Oliveira AF Cardoso SA Almeida FB | 2012 | Microbiology and Immunology2012，56，8： | 1 |
| 16 | Value of-FDG-PET/CT as a predictor of cancer in solitary pulmonary nodule显示文摘 | Martins RC Almeida SA Oliveira Siciliano AA | 2008 | J Bras Pneumol2008，34，7： | 1 |
| 17 | Epidemiological patterns of musculoskeletal injuries and physical training 显示文摘 | Almeida SA Williams KM Shaffer RA | 1999 | Med Sci Sports Exerc1999，8，： | 1 |
| 18 | Assess- ment of the perceived quality of life of successful kidney transplant recipients and their donors pre- and post-transplantation 显示文摘 | Joshi SA Almeida N Almeida A | 2013 | Transplant Proc2013，45，4： | 1 |
| 19 | Risk factors associated with inflammatory bowel disease: A multicenter case-control study in Brazil显示文摘BACKGROUND The etiology of inflammatory bowel disease(IBD)is unknown,but it is believed to be multifactorial.The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases.AIM To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development indices.METHODS A multicenter case-control study was carried out with 548 Crohn’s disease(CD)and 492 ulcerative colitis(UC)outpatients and 416 healthy controls,from six IBD centers within different Brazilian states at diverse socioeconomic development stages.A semi-structured questionnaire with 87 socioeconomic and environmental questions was applied.Logistic regression model was created to assess the odds ratio(OR)with P value and 95%confidence intervals(CI).RESULTS Predictive variables for both diseases(CD and UC)were women[odd ratios(OR)=1.31;OR=1.69],low monthly family income(OR=1.78;OR=1.57),lower number of cohabitants(OR=1.70;OR=1.60),absence of vaccination(OR=3.11;OR=2.51),previous history of bowel infections(OR=1.78;OR=1.49),and family history of IBD(OR=5.26;OR=3.33).Associated risk factors for CD were age(18-39 years)(OR=1.73),higher educational level(OR=2.22),absence of infectious childhood diseases(OR=1.99).The UC predictive variables were living in an urban area(OR=1.62),inadequate living conditions(OR=1.48)and former smokers(OR=3.36).Appendectomy was a risk factor for CD(OR=1.58)with inverse association with UC(OR=4.79).Consumption of treated and untreated water was associated with risk of CD(OR=1.38)and UC(OR=1.53),respectively.CONCLUSION This is the first examining environmental exposures as risk factors for inflammatory bowel disease in Brazil.Most of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development. | Valéria Cristina Loureiro Salgado Ronir Raggio Luiz Neio Lucio Fernandes Boéchat Isabella Sued Leao Bianca do Carmo Schorr JoséMiguel Luz Parente Daniela Calado Lima Eduardo Santos Silveira Júnior Genoile Oliveira Santana Silva Neogélia Pereira Almeida Andrea Vieira Maria Luiza Queiroz de Bueno Júlio Maria Chebli érika Ruback Bertges Luísa Martins da Costa Brugnara Columbano Junqueira Neto Stefania Burjack Gabriel Campbell Luana Letiza Discacciati Joao Paulo Silva Cézar Tiago Nunes Gilaad G Kaplan Cyrla Zaltman | 2020 | World Journal of Gastroenterology2020，26，25： | 1 |
| 20 | Exercise training reduces cardiac dysfunction and remodeling in ovariectomized rats submitted to myocardial infarction显示文摘 | Almeida SA Claudio ER Mengal V | 2014 | PLo S One2014，9，11： | 1 |
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