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| 1 | Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing显示文摘The impact of the microenvironment on innate lymphoid cell(ILC)-mediated immunity in humans remains largely unknown.Here we used full-length Smart-seq2 single-cell RNA-sequencing to unravel tissue-specific transcriptional profiles and heterogeneity of CD127+ILCs across four human tissues.Correlation analysis identified gene modules characterizing the migratory properties of tonsil and blood ILCs,and signatures of tissue-residency,activation and modified metabolism in colon and lung ILCs.Trajectory analysis revealed potential differentiation pathways from circulating and tissue-resident naïve ILCs to a spectrum of mature ILC subsets.In the lung we identified both CRTH2+and CRTH2−ILC2 with lung-specific signatures,which could be recapitulated by alarmin-exposure of circulating ILC2.Finally,we describe unique TCR-V(D)J-rearrangement patterns of blood ILC1-like cells,revealing a subset of potentially immature ILCs with TCR-δ rearrangement.Our study provides a useful resource for in-depth understanding of ILC-mediated immunity in humans,with implications for disease. | Luca Mazzurana Paulo Czarnewski Viktor Jonsson Leif Wigge Markus Ringnér Teresa CWilliams Avinash Ravindran Åsa KBjörklund Jesper Säfholm Gunnar Nilsson Sven-Erik Dahlén Ann-Charlotte Orre Mamdoh Al-Ameri Charlotte Höög Charlotte Hedin Sylwester Szczegielniak Sven Almer Jenny Mjösberg | 2021 | Cell Research2021，31，5： | 2 |
| 2 | Laboratory medicine for molecular imaging of atherosclerosis显示文摘 | Mangge H Almer G Stelzer I | 2014 | Clin Chim Acta2014，437，： | 1 |
| 3 | Inflammation, adiponectin, obesity and cardiovascular risk显示文摘 | Mangge H Almer G Truschnig-Wilders M | 2010 | Curr Med Chem2010，17，36： | 1 |
| 4 | Globular domain of adiponectin promising target molecule for detection of athero- sclerotic lesions显示文摘 | Almer G Saba - Lepek M Haj - Yahya S | 2011 | Biologics2011，5，： | 1 |
| 5 | Respiratory influence on heart rote in diabetes mellitus显示文摘 | Sundkvist G Almer L Lilja B | 1979 | British Medical Journal1979，1，6168： | 1 |
| 6 | High density lipoprotein cho- lesterol level is a robust predictor of lipid peroxidation irrespective of gender, age, obesity, and inflammatory or metabolic biomarkers 显示文摘 | Zelzer S Fuchs N Almer G | 2011 | Clin Chim Acta2011，412，1516： | 1 |
| 7 | Nuchal thickness of subcutaneous adipose tissue is tightly associated with an increased LMW/total adiponectin ratio in obese juveniles显示文摘 | Mangge H Almer G Haj-Yahya S | | 0，，： | 1 |
| 8 | Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model显示文摘 | Kikuchi H Almer G Yamashita S | 2006 | Proc Natl Acad Sci USA2006，103，15： | 1 |
| 9 | Inflammation, adiponectin, obesity and cardiovascular risk显示文摘 | Mangge H Almer G Truschnig-Wilders M | 2010 | Curr Med Chem2010，17，36： | 1 |
| 10 | Inflamma-tion,adiponectin,obesity and cardiovascular risk显示文摘 | Mangge H Almer G Truschnig Wilders M | | 0，，36： | 1 |
| 11 | Increased expression of the pro-inflammatory enzyme cyclooxygenase-2 in amyotrophic lateral sclerosis显示文摘 | Almer G Guegan C Teismann P | 2001 | Ann Neurol2001，49，： | 1 |
| 12 | Adiponectin-eoaled nanoparticles for enhanced imaging of atherosclerofic plaques 显示文摘 | Almer G Wemig K Saba-Lepek M | 2011 | Int J Nanomedicine2011，6，： | 1 |
| 13 | Microstructure, stress and mechanical properties of arc-evaporated Cr-C-N coatings 显示文摘 | Almer J Odin M Hfikansson G | 2001 | Thin Solid Films2001，385，12： | 1 |
| 14 | Phospholipase A2 activity of colonic mucosa in patients with ulcerative colitis显示文摘 | Almer S Franzen L Olaison G | 1991 | Digestion1991，50，34： | 1 |
| 15 | Spinal cord endoplasmic reticulum stress associated with a micro- somal accumulation of mutant superoxide dismutase - 1 in an ALS model显示文摘 | Kikuchi H Almer G Yamashita S | 2006 | Proc Natl Aead Sci U S A2006，103，： | 1 |
| 16 | Inflamma- tion, adiponectin, obesity and cardiovascular risk 显示文摘 | Mangge H Almer G Truschnig Wilders M eta | 2010 | Curr Med Chem2010，17，36： | 1 |
| 17 | Microstructure and thermal stability of arc-evaporated Cr-C-N coatings 显示文摘 | ALMER J ODEN M HAKANSSON G | 2004 | Philosophical Magazine2004，84，7： | 1 |
| 18 | Interleukin-10:an antiin- flammatory marker to target atherosclerotie lesions via PEGylated li- posomes显示文摘 | Almer G Frascione D Pali-Scholl I | 2013 | Mol Pharm2013，10，1： | 1 |
| 19 | Inflammation, adiponectin, obesity and cardiovascular risk显示文摘 | Mangge H Almer G Tmschnig-Wilders M | 2010 | Curr Med Chem2010，17，36： | 1 |
| 20 | Delayed gastric emptying rate in type 1 diabetics with cardiac autonomic neuropathy显示文摘 | Darwiche G Almer LO Bjorgell O | 2001 | J Diabetes Complications2001，15，3： | 1 |
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