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| 1 | New strategies for colorectal cancer screening显示文摘Colorectal cancer (CRC) is still one of the leading causes of cancer-related death in Western countries, despite major improvements in its treatment. The dramatically high social and economic impact of CRC on human health makes the identification of a reliable screening tool of paramount importance. Current screening methods, such as the fecal occult blood test and colonoscopy do not adequately meet the ideal requisites of a screening test because, even if they are effective, they are limited first by too low specificity and sensitivity, or second by high invasiveness, costs and risk. Nowadays extended efforts are made by researchers to look for more reliable and effective screening tests based on a systems biology approach, using biological samples easily available, such as urine, breath, serum and feces. The effectiveness and reliability of several new attempts to screen these patients by non-invasive analysis of their biological samples using genomic (genetic and epigenetic alteration), transcriptomic (miRNA), proteomic (cancer-related antigens, new antibodies against tumor-associated antigens, mutated proteins) and metabolomic (volatile organic metabolites) methods are discussed in this review. Among the most interesting new screening tools, fecal fluorescent long-DNA, fecal miRNA and metabolomic evaluation in breath and/ or serum seem to be most promising. | Maria Di Lena Elisabetta Travaglio Donato F Altomare | 2013 | World Journal of Gastroenterology2013，19，12： | 12 |
| 2 | Sphincteroplasty for fecal incontinence in the era of sacral nerve modulation显示文摘The role of sphincteroplasty in the treatment of patients with fecal incontinence due to anal sphincter defects has been questioned because the success rate declines in the long-term.A new emerging treatment for fecal incontinence,sacral nerve stimulation,has been shown to be effective in these patients.However,the success rate of sphincteroplasty may depend of several patient-related and surgical-related factors and the outcome from sphincteroplasty has been evaluated differently(with qualitative data) from that after sacral nerve stimulation(quantitative data using scoring systems and quality of life).Furthermore,the data available so far on the longterm success rate after sacral nerve modulation do not differ substantially from those after sphincteroplasty.The actual data do not support the replacement of sphincteroplasty with sacral nerve stimulation in patients with fecal incontinence secondary to sphincter defects. | Donato F Altomare Michele De Fazio Ramona Tiziana Giuliani Giorgio Catalano Filippa Cuccia | 2010 | World Journal of Gastroenterology2010，16，42： | 2 |
| 3 | Prospective randomized multicentre trial comparing stapled with open hemorrhoidectomy 显示文摘 | Ganio E Altomare D F Gabrilli F | 2001 | Br J Surg2001，88，： | 1 |
| 4 | Combined peri- neal and endorectal repair of rectocele by circular stapler显示文摘 | Donato F Altomare MR Antonella V | 2002 | Dis Colon Rectum2002，，45： | 1 |
| 5 | Form homogenepus to supported metallocene catalysts 显示文摘 | Ciardelli F Altomare A Michelotti M | 1998 | Catalysis Today1998，41，13： | 1 |
| 6 | Prospective randomized multicentre trial comparing stapled with open hemorrhoidectomy显示文摘 | Altomare DF Gabrilli F | 2001 | Br J Surg2001，88，： | 1 |
| 7 | From homogeneous to supported metaUocene catalysts显示文摘 | Ciardelli F Altomare A Michelotti M | | 0，，1： | 1 |
| 8 | Long-termoutcome of a multicentre randomized clinical trial of stapledhaemorrhoidopexy versus Milligan-Morgan haemorrhoidectomy显示文摘 | Ganio E Altomare D F Milito G | 2007 | Br J Surg2007，94，8： | 1 |
| 9 | Holographic Gratings in Azobenzene Side-Chain Polymethacrylates显示文摘 | Altomare A Ciardelli F | 1999 | Macromolecules1999，32，2： | 1 |
| 10 | 4-Vinylazobenzene:Polymerizability and Photochromic Properties of Its Polymers显示文摘 | Ciardelli F Solaro R | 1997 | Macromolecules1997，30，5： | 1 |
| 11 | 显示文摘 | Andruzzi L Altomare A Ciardelli F | 1999 | Macromolecules1999，32，： | 1 |
| 12 | Prospective randomized multi-centre trial comparing stapled with open hemorrhoidectomy显示文摘 | Ganio E Altomare DF Gabrilli F | 2001 | Br J Surg2001，88，5： | 1 |
| 13 | Title Long-term outcome of a multicentre randomized clinical trial of stapled hemorrhoidopexy versus Milligan-Morgan hemorrhoidectomy显示文摘 | GANIO E ALTOMARE D F MILITO G | 2007 | Source Brit J Surg2007，94，8： | 1 |
| 14 | Form homogenepus to suppor- ted metallocene catalysts 显示文摘 | Ciardelli F Altomare A Michelotti M | 1998 | Catalysis Today1998，41，13： | 1 |
| 15 | From homogeneous to supported metallocene catalysts显示文摘 | Ciardeni F Altomare A Michelotti M | 1998 | Catalysis Today1998，41，13： | 1 |
| 16 | Prospective randomized multicentre trial comparing stapled with open haemorrhoidectomy显示文摘 | Ganio E Altomare DF Gabrielli F | 2001 | Br J Surg2001，88，5： | 1 |
| 17 | Muhicentre retrospective analysis of the outcome of artificial anal sphincter implantation for severe faecal incontinence 显示文摘 | ALTOMARE D F DODI G LA TORRE F | 2001 | Br J Surg2001，88，11： | 1 |
| 18 | Prospective randomized multicentre trial comparing stapled with open hamorrhoidectomy显示文摘 | Ganio E Altomare DF Gabrielli F | 2001 | Br J Surg2001，88，5： | 1 |
| 19 | Intracameral bevacizumab in the treatment of neovascular glaucoma and exudative retinal detachment after brachytherapy in choroidal melanoma显示文摘 | Vasquez LM Somard S Altomare F Simpson ER | 2009 | Can J Ophthalmol2009，44，1： | 1 |
| 20 | Prospective randomized multicentre trial comparing stapled with open haemorrhoidectomy显示文摘 | Ganio E Altomare DF Gabrielli F | 2001 | Br J Surg2001，88，5： | 1 |
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