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| 1 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 2 | Fascin is a key regulator of breast cancer invasion that acts via the modification of metastasis-associated molecules显示文摘 | AI Alwan M Olabi S Ghebeh H | 2011 | PLoS One2011，6，27： | 1 |
| 3 | The Problem of Misplaced Control Limits显示文摘 | Alwan L C Roberts H V | 1995 | J of the Royal Statistical Society Series C1995，44，3： | 1 |
| 4 | A Multipath Routing Approach for Secure and Reliable Data Delivery in Wireless Sensor Networks显示文摘 | Alwan H Agarwal A | 2013 | International Journal of Distributed Sensor Networks2013，23，7： | 1 |
| 5 | Phenotypic and functional characterization of T cell lines specific for individual respiratory syncytial virus proteins显示文摘 | Alwan W H Record F M Openshaw P J | 1993 | J Immunol1993，150，： | 1 |
| 6 | Crystalloid versus cold blood cardioplegia and cardiac troponin I release 显示文摘 | Piehon H Choeron S Alwan K | 1997 | Circulation1997，96，： | 1 |
| 7 | Phenotypic and functional characterization of T cell lines specific for individual respiratory syncytial virus proteins显示文摘 | Alwan W H Record F M Openshaw P J | 1993 | J Immunol1993，150，： | 1 |
| 8 | Crystallo id versus coldblood cardioplegia and cardiac troponin I release显示文摘 | Piehon H Chocron S Alwan K | 1997 | Cir- culation1997，96，1： | 1 |
| 9 | Fiber pullout and bond slip I:analytical study,II:experimental validation显示文摘 | NAMUR G ALWAN J M NAJM H | 1991 | ASCE J of StructuralEngineering1991，117，： | 1 |
| 10 | Time-series modeling for statistical process control显示文摘 | Alwan L C Roberts H V | 1988 | Journal of Business and Economic Statistics1988，6，1： | 1 |
| 11 | Solving support vector ma- chine model selection problem using continuous ant colony optimizafion显示文摘 | Alwan H B Ku-Mahamud K R | 2013 | International Journal of Information Process- ing and Management2013，4，2： | 1 |
| 12 | Crystalloid versus cold blood cardioplegia and cardiac troponin I release显示文摘 | PICHON H CHOCRON S ALWAN K | 1997 | Circulation1997，96，： | 1 |
| 13 | Time-series modeling for statistical process control 显示文摘 | ALWAN L C ROBERTS H V | 1988 | Journal of Business and Economics Statistics1988，6，1： | 1 |
| 14 | Time-series modeling for statistical process control显示文摘 | Alwan L C Roberts H V | 1988 | Journal of Business and Economic Statistics1988，6，1： | 1 |
| 15 | Time-series modeling for statistical process control显示文摘 | ALWAN L C ROBERTS H V | 1988 | Journal of Business and Economics Statistics1988，6，1： | 1 |
| 16 | The problem of misplaced control limits 显示文摘 | Alwan L C and Roberts H V | 1995 | Journal of Royal Statistical Society (Series C)1995，44，3： | 1 |
| 17 | The problem of misplaced control limits显示文摘 | Alwan L C and Roberts H V | 1995 | Journal of Royal Statistical Society(Series C)1995，44，3： | 1 |
| 18 | Time-series modeling for statistical process control 显示文摘 | Alwan L C and Roberts H V | 1988 | Journal of Business and Economics Statistics1988，6，1： | 1 |
| 19 | Crystalloid versus cold blood cardioplegia and cardiac Troponin I release显示文摘 | Pichon H Chocron S Alwan K | 1997 | Circulation1997，96，： | 1 |
| 20 | Impact of blood pressure telemonitoring on hypertension outcomes:a literature review显示文摘 | ABUDAGGA A RESNICK H E ALWAN M | 2010 | TelemedJ E Health2010，16，： | 1 |
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