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| 1 | Selecting suitable solid organ transplant donors: Reducing the risk of donor-transmitted infections显示文摘Selection of the appropriate donor is essential to a successful allograft recipient outcome for solid organ transplantation. Multiple infectious diseases have been transmitted from the donor to the recipient via transplantation. Donor-transmitted infections cause increased morbidity and mortality to the recipient. In recent years, a series of high-profile transmissions of infections have occurred in organ recipients prompt-ing increased attention on the process of improving the selection of an appropriate donor that balances the shortage of needed allografts with an approach that mitigates the risk of donor-transmitted infection to the recipient. Important advances focused on improving donor screening diagnostics, using previously excluded high-risk donors, and individualizing the selection of allografts to recipients based on their prior infection history are serving to increase the donor pool and improve outcomes after transplant. This article serves to review the relevant literature surrounding this topic and to provide a suggested approach to the selection of an appropriate solid organ transplant donor. | Christopher S Kovacs Jr Christine E Koval David van Duin Amanda Guedes de Morais Blanca E Gonzalez Robin K Avery Steven D Mawhorter Kyle D Brizendine Eric D Cober Cyndee Miranda Rabin K Shrestha Lucileia Teixeira Sherif B Mossad | 2014 | World Journal of Transplantation2014，4，2： | 7 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Using quality improvement methods to increase use of pain prevention strategies for childhood vaccination显示文摘AIM To increase evidence-based pain prevention strategy use during routine vaccinations in a pediatric primary care clinic using quality improvement methodology.METHODS Specific intervention strategies(i.e.,comfort positioning,nonnutritive sucking and sucrose analgesia,distraction) were identified,selected and introduced in three waves,using a Plan-Do-Study-Act framework.System-wide change was measured from baseline to post-intervention by:(1) percent of vaccination visits during which an evidence-based pain prevention strategy was reported as being used; and(2) caregiver satisfaction ratings following the visit.Additionally,self-reported staff and caregiver attitudes and beliefs about pain prevention were measured at baseline and 1-year post-intervention to assess for possible long-term cultural shifts.RESULTS Significant improvements were noted post-intervention.Use of at least one pain prevention strategy was documented at 99% of patient visits and 94% of caregivers were satisfied or very satisfied with the pain prevention care received.Parents/caregivers reported greater satisfaction with the specific pain prevention strategy used [t(143) = 2.50,P ≤ 0.05],as well as greater agreement that the pain prevention strategies used helped their children's pain [t(180) = 2.17,P ≤ 0.05] and that they would be willing to use the same strategy again in the future [t(179) = 3.26,P ≤ 0.001] as compared to baseline.Staff and caregivers also demonstrated a shift in attitudes from baseline to 1-year post-intervention.Specifically,staff reported greater agreement that the pain felt from vaccinations can result in harmful effects [2.47 vs 3.10; t(70) =-2.11,P ≤ 0.05],less agreement that pain from vaccinations is 'just part of the process' [3.94 vs 3.23; t(70) = 2.61,P ≤ 0.05],and less agreement that parents expect their children to experience pain during vaccinations [4.81 vs 4.38; t(69) = 2.24,P ≤ 0.05].Parents/caregivers reported more favorable attitudes about pain prevention strategies for vaccinations across a variety of areas,including safety,cost,time,and effectiveness,as well as less concern about the pain their children experience with vaccination [4.08 vs 3.26; t(557) = 6.38,P ≤ 0.001],less need for additional pain prevention strategies [3.33 vs 2.81; t(476) = 4.51,P ≤ 0.001],and greater agreement that their doctors' office currently offers pain prevention for vaccinations [3.40 vs 3.75; t(433) =-2.39,P ≤ 0.05].CONCLUSION Quality improvement methodology can be used to help close the gap in implementing pain prevention strategies during routine vaccination procedures for children. | Jennifer Verrill Schurman Amanda D Deacy Rebecca J Johnson Jolynn Parker Kristi Williams Dustin Wallace Mark Connelly Lynn Anson Kevin Mroczka | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 3 |
| 4 | Impact of a simulation-based induction programme in gastroscopy on trainee outcomes and learning curves显示文摘BACKGROUND Pre-clinical simulation-based training(SBT)in endoscopy has been shown to augment trainee performance in the short-term,but longer-term data are lacking.AIM To assess the impact of a two-day gastroscopy induction course combining theory and SBT(Structured PRogramme of INduction and Training–SPRINT)on trainee outcomes over a 16-mo period.METHODS This prospective case-control study compared outcomes between novice SPRINT attendees and controls matched from a United Kingdom training database.Study outcomes comprised:(1)Unassisted D2 intubation rates;(2)Procedural discomfort scores;(3)Sedation practice;(4)Time to 200 procedures;and(5)Time to certification.RESULTS Total 15 cases and 24 controls were included,with mean procedure counts of 10 and 3(P=0.739)pre-SPRINT.Post-SPRINT,no significant differences between the groups were detected in long-term D2 intubation rates(P=0.332)or discomfort scores(P=0.090).However,the cases had a significantly higher rate of unsedated procedures than controls post-SPRINT(58%vs 44%,P=0.018),which was maintained over the subsequent 200 procedures.Cases tended to perform procedures at a greater frequency than controls in the post-SPRINT period(median:16.2 vs 13.8 per mo,P=0.051),resulting in a significantly greater proportion of cases achieving gastroscopy certification by the end of follow up(75% vs 36%,P=0.017).CONCLUSION In this pilot study,attendees of the SPRINT cohort tended to perform more procedures and achieved gastroscopy certification earlier than controls.These data support the role for wider evaluation of pre-clinical induction involving SBT. | Keith Siau James Hodson Peter Neville Jeff Turner Amanda Beale Susi Green Aravinth Murugananthan Paul Dunckley Neil D Hawkes | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，3： | 2 |
| 5 | Electronic remote blood issue:a combination of remote blood issue with a system for end-to-end electronic control of transfusion to provide a 'total solution' for a safe and timely hospital blood transfusion service 显示文摘 | Julie S Amanda D Jonathan K | 2008 | Transfusion2008，，： | 1 |
| 6 | Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women 显示文摘 | Prince RL Amanda D Dhaliwal SS | 2006 | Archives of Internal Medicine2006，166，8： | 1 |
| 7 | The analytical investigation of synthetic street drugs containing cathinone analogs显示文摘 | Amanda M L Philip B S Adriana D A | 2014 | Forensic Sci Int2014，234，： | 1 |
| 8 | Evaluation of the poten-tial emissions reductions from the use of CHP systems indifferent commercial buildings显示文摘 | Mago Pedro J Smith Amanda D | 2012 | Building and Environ-ment2012，53，： | 1 |
| 9 | Demonstration of TCDD-attenuated P450 steroidogenic enzyme mRNA levels in rat granulosa cells in vitro using competitive RT-PCR显示文摘 | Asok K D Barbara A B W Amanda L T | 2000 | Mol Cell Endocrinol2000，164，： | 1 |
| 10 | HPLC-MS analysis of phenolic compounds and purine alkaloids in green and black tea显示文摘 | DANIELE D R AMANDA J S WILLIAM M | 2004 | J of Agricultral and Food Chemistry2004，，10： | 1 |
| 11 | Electronic remote blood issue: a combination of remote blood issue with a system for end-to-end electronic control of transfusion to provide a 'total solution' for a safe and timely hospital blood transfusion service 显示文摘 | Julie S Amanda D Jonathan K | 2008 | Transfusion2008，48，3： | 1 |
| 12 | Hepatitis B and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort显示文摘 | Deborah Konopnicki Amanda Mocroft S de Wit Francisco Antunes Bruno Ledergerber Christine Katlama K Zilmer Stefano Vella Ole Kirk Jens D Lundgren | 2005 | AIDS2005，，6： | 1 |
| 13 | Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH 显示文摘 | Dayane D da-Rosa Samira S Valvassori Amanda V Steckert | 2012 | Psychiatry Res2012，198，3： | 1 |
| 14 | Lymphocytes and the adventitial immune response in atherosclerosis 显示文摘 | Kirsti A C Michael J L Amanda C D | 2012 | Circ Res2012，110，6： | 1 |
| 15 | Reversal of endocardial endothelial dysfunction by folic acid in homocysteinemic hypertensive rats显示文摘 | Amanda Miller Vibhas Mujumdar Lena Palmer John D Bower Suresh C Tyagi | 2002 | American Journal of Hypertension2002，，2： | 1 |
| 16 | Enhancing caregiver health: Findings from the resources for enhancing Alzheimer's caregiver health II intervention显示文摘 | AMANDA F LOUIS D JAMIE D | 2010 | J Am C eriatr Soe2010，58，1： | 1 |
| 17 | Cell immobilization us ing PVA crosslinked with boric acid 显示文摘 | Amanda Wu K Y Wisecarver K D | 1992 | Biotechn Bioeng1992，39，： | 1 |
| 18 | HPLC-MS analysis of phenolic compounds and purine alkaloids in green and black tea显示文摘 | Daniele D R Amanda J S William M | 2004 | J Aric Food Chem2004，52，10： | 1 |
| 19 | Molecular - phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases 显示文摘 | FRANF D N St AMANDA L FELDMAN R A | 2007 | Pmc Nat[ Acad Sci USA2007，104，13： | 1 |
| 20 | A very early rehabilitation trial for stroke (AVERT) phase II safety and feasibility显示文摘 | Julie B Helen D Amanda T Pet at al | 2008 | Stroke2008，39，： | 1 |
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