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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Sessler,Relationship between Intraoperative Mean Arterial Pressure and Clinical Outcomes after Noncardiac Surgery: Toward an Empirical Definition of Hypotension显示文摘 | Michael Walsh Philip J Devereaux Amit X Garg | 2013 | Anesthesiology2013，119，： | 1 |
| 3 | A coarse-to t'ine strate gy for multi class shape detection显示文摘 | AMIT Y GEMAN D FAN X | 2004 | IEEE Transac- tions on Pattern Analysis and Machine Intelligence2004，26，12： | 1 |
| 4 | Fulllength transcriptome assembly from RNA-Seq datawithout a reference genome显示文摘 | Grabherr M G Haas B J Yassour M Levin J Z Thompson DA Amit I Adiconis X Fan L Raychowdhury R Zeng Q | 2011 | Nature Biotechnology2011，29，7： | 1 |
| 5 | Marked variation in the definition and diagnosis of delayed graft function : a systematic review显示文摘 | SRI G Y STEVEN G C AMIT X G | 2008 | Nephrol Dial Transplant2008，23，： | 1 |
| 6 | Burden on earegivers as perceived by hemodialysis patients in the Frequent Hemodial- ysis Network (FHN) trials 显示文摘 | Suri RS Brett Larive Amit X | 2011 | Nephrol Dial Transplant2011，26，： | 1 |
| 7 | A Coarse-to-fine Strate gy for Multi-class Shape Detection显示文摘 | Amit Y Geman D Fan X | 2004 | IEEE Trans actions on Pattern Analysis and Machine Intelli gence2004，26，12： | 1 |
| 8 | A coarse-to-fine strategy for multiclass shape detection显示文摘 | Amit Y Geman D Fan X | | 0，，12： | 1 |
| 9 | Burden on caregivers as perceived by hemodialysis patients in the Frequent Hemodialysis Network (FHN) trials显示文摘 | Suri RS Larive B Amit X | 2011 | Nephrol Dial Transplant2011，26，7： | 1 |
| 10 | Risk factors for fracture in adult kidney transplant recipients显示文摘AIM: To determine the general and transplant-specific risk factors for fractures in kidney transplant recipients.METHODS: We conducted a cohort study of all adults who received a kidney-only transplant(n = 2723) in Ontario, Canada between 2002 and 2009. We used multivariable Cox proportional hazards regression to determine general and transplant-specific risk factors for major fractures(proximal humerus, forearm, hip, and clinical vertebral). The final model was established using the backward elimination strategy, selecting risk factors with a P-value ≤ 0.2 and forcing recipient age and sex into the model. We also assessed risk factors for other fracture locations(excluding major fractures, and fractures involving the skull, hands or feet). RESULTS: There were 132 major fractures in the follow-up(8.1 fractures per 1000 person-years). General risk factors associated with a greater risk of major fracture were older recipient age [adjusted hazard ratio(a HR) per 5-year increase 1.11, 95%CI: 1.03-1.19] and female sex(a HR = 1.81, 95%CI: 1.28-2.57). Transplant-specific risk factors associated with a greater risk of fracture included older donor age(5-year increase)(a HR = 1.09, 95%CI: 1.02-1.17) and end-stage renal disease(ESRD) caused by diabetes(a HR = 1.72, 95%CI: 1.09-2.72) or cystic kidney disease(a HR = 1.73, 95%CI: 1.08-2.78)(compared to glomerulonephritis as the reference cause). Risk factors across the two fracture locations were not consistent(major fracture locations vs other). Specifically, general risk factors associated with an increased risk of other fractures were diabetes and a fall with hospitalization prior to transplantation, while length of time on dialysis, and renal vascular disease and other causes of ESRD were the transplant-specific risk factors associated with a greater risk of other fractures.CONCLUSION: Both general and transplant-specific risk factors were associated with a higher risk of fractures in kidney transplant recipients. Results can be used for clinical prognostication. | Kyla L Naylor Guangyong Zou William D Leslie Anthony B Hodsman Ngan N Lam Eric McArthur Lisa-Ann Fraser Gregory A Knoll Jonathan D Adachi S Joseph Kim Amit X Garg | 2016 | World Journal of Transplantation2016，6，2： | 0 |
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