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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 3 | Modulation of aquaporins-4 water transport in a model of TBI显示文摘 | Amorini AM Dunbar JG Marmaroa A | 2003 | Aeta Neuroehir suppl2003，，： | 1 |
| 4 | Modulation of aquaporin-4 water transport in a model of TBI显示文摘 | Amorini AM Dunbar JG Marmarou A | 2003 | Acta Neurochir Suppl2003，，： | 1 |
| 5 | The Protein Kinase C Activator Phorbol Myristate Acetate Decreases Brain Edema by Aquaporin 4 Down-Regulation after Middle Cerebral Artery Occlusion in the Rat显示文摘 | Fazzina G Amorini AM Marmarou CR | 2010 | J Neurotrauma2010，27，1： | 1 |
| 6 | Modulation of AQP-4 expression by the protein kinase C activator, phorbol myristate acetate, decreases ischemia-induced brain edema显示文摘 | Kleindienst A Fazzina G Amorini AM | 2006 | Acta Neurochir2006，96，： | 1 |
| 7 | Modulation of aqua-porin24water transport in a model of TBI显示文摘 | Amorini AM Dunbar JG Marmarou A | 2003 | Acta NeurochirSuppl2003，86，： | 1 |
| 8 | Modulation of AQP4 water transport in s model ofTBI显示文摘 | AMORINI A M DUNBAR J G MARMAROU A | 2003 | Acta Neurechir Suppl2003，86，： | 1 |
| 9 | Modulation of AQP4 expression by the protein kinase C activator, phorbol myristate acetate, decreases ischemia-induced brain edema 显示文摘 | Kleindienst A Fazzina G Amorini AM | 2006 | Acta Neurochir Suppl2006，96，： | 1 |
| 10 | Modulation of aquaporin-4 water transport in a model of TBI显示文摘 | Amorini AM Dunbar JG Marmarou A | 2003 | Acta Neurochir Suppl2003，86，： | 1 |
| 11 | Antioxidant capacity,ascorbic acid, total phenols and carotenoids changes during harvest and after storage ofH hayward kiwifruit显示文摘 | Silvia Tavarini Elena Degl Damiana Amorini | 2008 | Food Chemistry2008，107，： | 1 |
| 12 | The protein ki- nase C activator phorbol myristate acetate decreases brain ede- ma by aquaporin 4 downregulation after middle cerebral artery occlusion in the rat显示文摘 | Fazzina G Amorini A M Marmarou C R | 2010 | J Neurotrauma2010，27，2： | 1 |
| 13 | The PKC activator phorbol myristate acetate decreases brain edema by AQP4downregulation after middle cerebral artery occlusion in the rat显示文摘 | Fazzina G Amorini AM Marmarou CR | 2010 | J Neurotrauma2010，，27： | 1 |
| 14 | S100B and glial fibrillary acidic protein as indexes to monitor Dam- age Severity in an in vitro model of traumatic brain in- jury 显示文摘 | Di Pietro V Amorini AM Lazzarino G | 2015 | Neurochem Res2015，40，5： | 1 |
| 15 | Activity and mechanism of the antioxidant properties of cyanidin-3-O-13-glucopyranoside显示文摘 | Amorini A M Fazzina G Lazzarino G | 2001 | Free Radical Research2001，35，6： | 1 |
| 16 | Digital pulse shape acquisition from BaF2 : preliminary results 显示文摘 | Amorini F De Filippo E Guazzoni P | 2006 | IEEE2006，1，： | 1 |
| 17 | Digital pulse shape acquisition from BaF2: Preliminary results 显示文摘 | AMORINI F de FILIPPO E GUAZZONI P | 2006 | IEEE Nuclear Science Symposium Conference Record2006，14，： | 1 |
| 18 | Modulation of AQP-4 expression by the protein kinase C activator: phorbol myristate acetate decreases ischemia-induced brain edema 显示文摘 | Kleindienst A Fazzina G Amorini AM | 2006 | Acta Neurochir Suppl2006，96，： | 1 |
| 19 | Clinical, biochemical and molecular diagnosis of a compound homozygote for the 254 bp deletion - 8 bp insertion of the APRT gene suffering from severe renal failure 显示文摘 | Pietro V D Perruzza I Amorini A M | 2007 | Clin Biochem2007，40，： | 1 |
| 20 | Modulation of AQP-4 expression by the protein kinase C activator: phorbol myristate acetate decreases ischemia-induced brain edema显示文摘 | Kleindienst A Fazzina G Amorini AM | 2006 | Acta Neurochir Suppl2006，96，： | 1 |
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