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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | Exploring novel bioactive compounds from marine microbes 显示文摘 | ZHANG L X AN R WANG J P | 2005 | Current Opinion in Microbiology2005，8，： | 1 |
| 3 | A novel drought-inducible gene,A TAF1,encodes a NAC family protein that negatively regulates the expression of stress-responsive genes in Arabidopsis显示文摘 | LU P L CH EN N Z AN R SU Z QI B S REN F CHEN J WANG X C | 2007 | Plant Molecular Biology2007，63，2： | 1 |
| 4 | Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography 显示文摘 | Wang R K An L Francis P | 2010 | Optics Letters2010，35，9： | 1 |
| 5 | Depth-resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography显示文摘 | Wang RK An L Francis P | 2010 | Opt Lett2010，35，9： | 1 |
| 6 | View- adaptive motion estimation for low complexity multi- view video coding 显示文摘 | SHEN L Q LIU Z LIU S X ZHANG Z Y AN P | 2010 | IEEE Transactions on Circuits and Systems for Video Technology2010，20，6： | 1 |
| 7 | A fuzzy extension of Saaty's priority theory显示文摘 | V an L aarhoven P J M PedryczW | 1983 | Fuzzy Sets and Systems1983，11，： | 1 |
| 8 | Synthesis of PtRu/carbon nanotube composites in supercritical fluid and their application as an electrocatalyst for direct methanol fuel cells显示文摘 | An G Yu P Mao L | | 0，，03： | 1 |
| 9 | Agro-ecological engineering on coastal saline soil显示文摘 | QIN P ZHOU C L AN S Q | 2002 | Beijing:Chemical Industry Press2002，，： | 1 |
| 10 | A Supported Gold Catalyst for Elimination of Hydrogen from CO2 Feed Gas in the Production of Urea显示文摘 | An L D Wang H L | 1996 | React Kinet Catal Lett1996，59，： | 1 |
| 11 | Early skip mode decision for MVC using iter-view correlation 显示文摘 | SHEN L Q LIu Z YAN T ZHANG Z Y AN P | 2010 | Signal Processing: Image Communication2010，25，2： | 1 |
| 12 | Effect of support on reacativity and selectivity of Ni-based oxygen carriers for chemical-looping combustion显示文摘 | Gay An P Diego L F García-Labiano F | 2008 | Fuel2008，87，： | 1 |
| 13 | Plant gene net- works in osmotic stress response: from genes to regulatory net- works显示文摘 | Ti'an L S P Nakashirna K Shinozaki K | 2007 | Methods in Enzymology2007，428，： | 1 |
| 14 | Fast CU size decision and modedecision algorithm for HEVC Intra coding显示文摘 | L Q Shen Z Y Zhang P An | 2013 | IEEE Transactionson Consumer Electronics2013，59，1： | 1 |
| 15 | Comparison of the characteristics of anammox granules of different sizes显示文摘 | An P Xu X C Yang F L | 2013 | Biotechnology and Bioprocess Engineering2013，18，3： | 1 |
| 16 | Fast mode decision for scalable video coding utilizing spatial and interlayer correlation显示文摘 | Shen L Liu L An P | | 0，，01： | 1 |
| 17 | Miscibility and crystallization of poly(β-hydroxybutyrate) and poly(P-viny phenol)blends显示文摘 | Xing P Dong L S An Y X | 1997 | Macromolecules1997，30，： | 1 |
| 18 | Fast CU size decision and mode decision algorithm for HEVC intra coding 显示文摘 | SHEN L ZHANG Z AN P | 2013 | IEEE Transactions on Consumer Electronics2013，59，1： | 1 |
| 19 | Parameter selection of sup- port vector machines and genetic algorithm based on change area search 显示文摘 | ZHAO M Y REN J]AN J] L P | 2012 | Neural Computing and Applications2012，21，1： | 1 |
| 20 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
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