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| 1 | Clinical significance of tumor-infiltrating lymphocytes for gastric cancer in the era of immunology显示文摘Immunotherapy has begun to revolutionize cancer treatment, by introducing therapies that target the host immune system instead of the tumor, therapies that possess unique adverse event profiles, and therapies that may cure certain types of cancer. The immune microenvironment of tumors is emerging as the most important means of understanding the relationship between a patient' immune system and their cancer, informing prognosis, and guiding immunotherapy, such as an antibody blockade of immune checkpoints. For some solid tumors, simple quantitation of lymphocyte infiltration would seem to have prognostic significance, suggesting that lymphocyte infiltration is not passive but may actively promote or inhibit tumor growth. For gastric cancers, several studies have provided strong evidence that immune cells contribute to determining prognosis. However, the exact role of immune cells in gastric cancer remains unclear. Therefore, this review focuses on the clinical significance of immune cells, especially tumor-infiltrating lymphocytes, in gastric cancer. | Byung Woog Kang Jong Gwang Kim In Hee Lee Han Ik Bae An Na Seo | 2017 | World Journal of Gastrointestinal Oncology2017，9，7： | 3 |
| 2 | 大麝鼩韩国种群与俄罗斯远东种群之间的遗传分化:基于线粒体Cyt b基因的分析(英文)显示文摘为重新分析韩国大麝鼩种群与相邻的俄罗斯远东种群之间的遗传分化情况,我们获得9条来自韩国4个地点和俄罗斯3个地点的大麝鼩线粒体细胞色素b基因(Cyt b)全序列,并将其与来自Gen Bank的4条Cyt b全序列和4条Cyt b部分序列进行比较。结果发现韩国的大麝鼩并非只有一种基因型,因此,在利用Cyt b部分序列进行种群遗传学分析时需格外注意。基于Cyt b全序列分析,发现韩国的大麝鼩与俄罗斯远东地区的大麝鼩之间存在1.08%的平均JC距离和7个位点的差异,推测韩国的大麝鼩与俄罗斯远东地区的大麝鼩在包括末次冰盛期在内的很长时期都没有进行过遗传交流。目前的测序结果不支持当前认为大麝鼩为单系群的亚种分类理论,支持韩国大麝鼩是C.l.thomasi亚种的分类理论,但还需进一步对中国东北地区的样品进行测序分析后才能最终确认。 | KOH Hung Sun SHEREMETIEVA Irina JO Jae Eun SIN Dong Soen KIM Jin Seong AN Na Hyeon | 2014 | 兽类学报2014，34，4： | 2 |
| 3 | 基于甲基化DNA分离方法的甲基化DNA检测和全基因水平的甲基化分析显示文摘已知异常的DNA甲基化对基因表达有明显影响并且涉及包括癌症等的疾病以及正常状态,因此从非甲基化DNA中鉴定甲基化DNA的分析技术是非常必须的。本文介绍了一种利用甲基化DNA结合域对甲基化DNA的亲和性质将甲基化DNA从全基因中成功提取的甲基化DNA分离技术(MeDIA)。结合MeDIA的PCR和CpG芯片技术分别实现了局部位置甲基化DNA状态的评估以及全基因的甲基化分析。 | Young Ho Moon TaeJeong Oh Na Young Kim Myung Soon Kim Sungwhan An | 2010 | 生命科学仪器2010，8，1： | 1 |
| 4 | Structural and functional characterization of HP0377, a thioredoxin‐fold protein from Helicobacter pylori显示文摘 | Ji Young Yoon Jieun Kim Doo Ri An Sang Jae Lee Hyoun Sook Kim Ha Na Im Hye‐Jin Yoon Jin Young Kim Soon‐Jong Kim Byung Woo Han Se Won Suh | 2013 | Acta Cryst D2013，，5： | 1 |
| 5 | Associations between intakes of individual nutrients or whole food groups and non‐alcoholic fatty liver disease among K orean adults显示文摘 | Jung Mi Han An Na Jo Seung Min Lee Hyun Suk Bae Dae Won Jun Yong Kyun Cho Ki Tae Suk Jai Hoon Yoon Sang Bong Ahn Yong Jin Cho Seong Woo Kim Eun Chul Jang | 2014 | J Gastroenterol Hepatol2014，，6： | 1 |
| 6 | Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B显示文摘AIM:To evaluate the treatment outcomes of clevudine compared with entecavir in antiviral-naive patients with chronic hepatitis B(CHB).METHODS:We retrospectively analyzed the clinical data of CHB patients treated with clevudine 30 mg/d and compared their clinical outcomes with patients treated with entecavir 0.5 mg/d.The biochemical response,as assessed by serum alanine aminotransferase(ALT) activity,virologic response,as assessed by serum hepatitis B virus DNA(HBV DNA) titer,serologic response,as assessed by hepatitis B e antigen(HBeAg) status,and virologic breakthrough with genotypic mutations were assessed.RESULTS:Two-hundred and fifty-four patients [clevudine(n = 118) vs entecavir(n = 136)] were enrolled.In clevudine-treated patients,the cumulative rates of serum ALT normalization were 83.9% at week 48 and 91.5% at week 96(80.9% and 91.2% in the entecavir group,respectively),the mean titer changes in serum HBV DNA were-6.03 and-6.55 log 10 copies/mL(-6.35 and-6.86 log 10 copies/mL,respectively,in the entecavir group),and the cumulative non-detection rates of serum HBV DNA were 72.6% and 83.1%(74.4% and 83.8%,respectively,in the entecavir group).These results were similar to those of entecavir-treated patients.The cumulative rates of HBeAg seroconversion were 21.8% at week 48 and 25.0% at week 96 in patients treated with clevudine,which was similar to patients treated with entecavir(22.8% and 27.7%,respectively).The virologic breakthrough in the clevudine group occurred in 9(7.6%) patients at weeks 48 and 15(12.7%) patients at week 96,which primarily corresponded to genotypic mutations of rtM204I and/or rtL180M.There was no virologic breakthrough in the entecavir group.CONCLUSION:In antiviral-naive CHB patients,longterm treatment outcomes of clevudine were not inferior to those of entecavir,except for virologic breakthrough. | Suk Bae Kim Il Han Song Young Min Kim Ran Noh Ha Yan Kang Hyang Ie Lee Hyeon Yoong Yang An Na Kim Hee Bok Chae Sae Hwan Lee Hong Soo Kim Tae Hee Lee Young Woo Kang Eaum Seok Lee Seok Hyun Kim Byung Seok Lee Heon Young Lee | 2012 | World Journal of Gastroenterology2012，18，47： | 1 |
| 7 | Profiles of antioxidant gene expression and physiological changes by thermal and hypoosmotic stresses in black porgy ( Acanthopagrus schlegeli )显示文摘 | Kwang Wook An Na Na Kim Hyun Suk Shin Gyung-Suk Kil Cheol Young Choi | 2010 | Comparative Biochemistry and Physiology Part A2010，，2： | 1 |
| 8 | A comparison of short-term postoperative outcomes including nutritional status between gastrectomy with simultaneous cholecystectomy and gastrectomy only in patients with gastric cancer显示文摘Objective: We aimed to evaluate the effect of simultaneous cholecystectomy on the short-term postoperative outcomes and nutritional status in patients with gastric cancer.Methods: We retrospectively reviewed data from 4,820 patients with gastric cancer who underwent gastrectomy from January 2011 to December 2016. Patients who underwent only gastrectomy(N=4,578) were matched to those who underwent simultaneous cholecystectomy during gastrectomy(N=242) at a 1:1 ratio using propensity score matching analysis. The nutritional status and inflammatory responses preoperatively and postoperatively and postoperative outcomes were compared between the groups.Results: The simultaneous cholecystectomy group showed more intraoperative blood loss and a longer operative time than the gastrectomy only group [150.0(100.0, 200.0) m L vs. 100.0(100.0, 200.0) m L, P=0.006;176.0(150.0,210.0) min vs. 155.0(128.0, 188.0) min, P<0.001, respectively]. Intraoperative event rate, postoperative complication rate, and postoperative recovery did not differ between the groups. All parameters including body weight, the hemoglobin level, absolute lymphocyte count, total protein level, albumin level, fasting glucose level,and prognostic nutritional index excluding the cholesterol level were not significantly different between the groups,and their changing patterns were similar. Although the cholesterol level was significantly lower in the simultaneous cholecystectomy group than in the gastrectomy only group at all follow-up points, the mean value of the decreased cholesterol level was within normal range.Conclusions: In gastric cancer patients with gallbladder disease, simultaneous cholecystectomy is safe and not associated with additional nutritional loss. | You Na Kim Ji Yeong An Min-Gew Choi Jun Ho Lee Tae Sung Sohn Jae Moon Bae Sung Kim | 2019 | Chinese Journal of Cancer Research2019，31，3： | 0 |
| 9 | Comparison Between Full-Scale and Model Experiments of Oil Fences显示文摘This study examines the performance of an air expansion oil fence system as deployed in two different configurations.Geometric and tension characteristics of the oil fence are investigated for (1) the system attached to two vessels and (2) the system attached to one vessel with spreading devices.Since full-scale testing can be time consuming and expensive,another component of the study was to examine how well models would perform.A scaling technique was developed and a set of experiments were conducted with a 1/20-th scale model of the oil fence in a towing tank facility.Performance results from the model tests were compared with those conducted at sea.The tension (N) in the full-scale results were represented by R=avb,where v is the current velocity in m/s and the values for a and b used for comparison purposes.Both sets of full-scale and model tests were conducted with an oil fence opening of 120 m and 160 m.In the full-scale experiment with spreading devices attached to the forward ends of the oil fence,the horizontal distance of the spreading devices has a tendency to linearly increase as the current velocity increases when the warp length is as short as 50 m,but to linearly decrease as the current velocity increases when the warp length is extended to 100 m and 150 m.The spreading distance at uniform current velocitys in the model test increases as the warp length is extended.While there is no significant difference of spreading distance between the cases of 100 m and 150 m,the spreading distance becomes shorter when the warp length is 50 m. | Tae Ho KIM Duck Jong JANG Kyong Uk YANG Sun Chol NA Dae An KIM | 2009 | China Ocean Engineering2009，23，4： | 0 |
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