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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Posttreatment of a brewery wastewater using a sequencing batch reactor 显示文摘 | Rordrigues Ana C Brito Antonio G Melo Luis F | 2001 | Water Environment Research2001，73，1： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Strategies for scheduling optional tasks in intelligent real-time environment 显示文摘 | Ana G F Houcine H Alfons C | 1996 | Journal of of System Architecture1996，42，1： | 1 |
| 5 | Guiexperts显示文摘 | Irwig L Tosteson ANA Gatsonis C Lau J Colditz G Chalmers TC Mosteller F | 1992 | JAMA1992，268，： | 1 |
| 6 | BjussuSP-I:a new thrombin-like enzyme isolated from Bothropsjararacussu snake ven- om 显示文摘 | Sant' Ana C D Tic|i F K Oliveira L L | 2008 | Comp Biochem Physiol A Mol Integr Physiol2008，151，3： | 1 |
| 7 | Body composi-tion and net requirements of protein and energy for weight gain of nellore and crossbreed steers finished under grazing显示文摘 | Sant'Ana N F Fontes C A A Silva R S T | | 0，，04： | 1 |
| 8 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 9 | Epicuticular wax content and mor- phology as related to ethylene and storage performance of 'Navelate~ orange fruit显示文摘 | Jacques F C Luis G C Ana V | 2010 | Postharvest Biology and Technology2010，55，： | 1 |
| 10 | Ethylene polymerization catalyzed by metallocene supported on mesoporous materials显示文摘 | Maria de F V M Rdovaldo F C S Ana C S L S | 2008 | Polymer Bulletin2008，61，4： | 1 |
| 11 | Differential responses between mature and young leaves of sunflower plants to oxidative stress caused by water deficit显示文摘 | INES C NATALIA C TEREZINHA de F F ANA C C | 2010 | Ciincia Rural Santa Maria2010，40，6： | 1 |
| 12 | Molecularcharacterization of BjussuSP-I, a new thrombin-like enzyme withprocoagulant and kallikrein-like activity isolated from Bothrops jarar-acussu snake venom 显示文摘 | Sant Ana C D Bemardes C P Izidoro L F M | 2008 | Biochimie2008，90，： | 1 |
| 13 | Knowledge modelling for the motion detection task:the algorithmic lateral inhibition method显示文摘 | JOSE M ANA E D ANTONIO F C | 2004 | Expert Systems with Applications2004，27，： | 1 |
| 14 | Implications of iron solubilization on soil phosphorus release in seasonally flooded forests of the lower Orinoco River,Venezuela 显示文摘 | NOEMI C SAUL F ANA G | 2006 | Soil Biology Biochemistry2006，38，： | 1 |
| 15 | Nile Tilapia ( Oreochromis niloticus), Liver Morphology, CYP1A Activity and Thyroid Hormones After Endosulfan Dietary Exposure 显示文摘 | ANA M C ANTONIO F F MARIA A R | 2007 | Pesticide Biochemistry and Physiology2007，89，3： | 1 |
| 16 | An approach to chemotaxonomy to the fatty acid content of some Malvaceae species 显示文摘 | Oliveira S Ana C Morals O Antonio F | 2010 | Biochemical Systematics and Ecology2010，38，5： | 1 |
| 17 | Segmenting wine consumers according to their involvement with appellations of origin 显示文摘 | Carmen R S Miguel C B Ana G F | 2006 | Journal of Brand Management2006，13，45： | 1 |
| 18 | Arabidopsis and tobacco plants ectopically expressing the soybean antiquitin-like ALDH7 gene display enhanced tolerance to drought,salinity,and oxidative stress显示文摘 | Simone M R Maxuel O A Ana P S G Fabio M D Maria C B P Elizabeth P B F | | 0，，： | 1 |
| 19 | Protozoan parasites in captive chinchillas (Chinchilla lanigera) raised in the State of Rio Grande do Sul,Brazil显示文摘 | ANA C F G AMANDA D S S | 2005 | Parasitol Latinoam2005，60，34： | 1 |
| 20 | Preparation and characterization of chitosan/SiO2 composite films 显示文摘 | Oliveira F C Ana B T José A L S | 2010 | J Nanosci Nanotechnol2010，10，4： | 1 |
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