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| 1 | 枯草芽孢杆菌对蛋鸡后期生产性能及肠道健康的影响显示文摘为测定枯草芽孢杆菌对蛋鸡生产性能和肠道健康的影响,80羽64~75周健康罗曼白蛋鸡被随机分为两组,每组5个重复,每个重复8只鸡。对照组使用基础日粮,试验组在每吨基础日粮中添加200 g克洛生TM11粉剂。结果表明,与对照组相比,枯草芽孢杆菌组平均产蛋率为74.4%,比对照70%高4.4个百分点(P〈0.05),平均蛋重为64.8 g,比对照组61 g高3.8 g(P〈0.05)。对照组生产了8.4%的不可上市蛋,枯草芽孢杆菌组只有3.5%不可上市鸡蛋。日粮中添加克洛生后能提高饲料转化率、产蛋性能,改善蛋壳质量,减少不可上市鸡蛋。不仅如此,日粮中添加枯草芽孢杆菌组还能减少肠道梭菌和空肠弯曲杆菌的数量,增加乳酸杆菌和双歧杆菌的数量,通过肠道微生态的改善从而达到改善肠道健康,提高蛋壳质量,提高蛋鸡后期产蛋率(P〈0.05)。 | Anas Abdelqader Abdur-Rahman Al-Fataftaha Gürbüz Das 罗正 | 2013 | 饲料工业2013，34，23： | 7 |
| 2 | Pharmacogenomics in colorectal cancer: The first step for individualized-therapy显示文摘Interindividual differences in the toxicity and response to anticancer therapies are currently observed in practically all available treatment regimens. A goal of cancer therapy is to predict patient response and toxicity to drugs in order to facilitate the individualization of patient treatment. Identification of subgroups of patients that differ in their prognosis and response to treatment could help to identify the best available drug therapy according the genetic profile. Several mechanisms have been suggested to contribute to chemo-therapeutic drug resistance: amplification or overexpression of membrane transporters, changes in cellular proteins involved in detoxification or in DNA repair, apoptosis and activation of oncogenes or tumor suppressor genes. Colorectal cancer (CRC) is regarded as intrinsically resistant to chemotherapy. Several molecular markers predictive of CRC therapy have been included during the last decade but their results in different studies complicate their application in practical clinical. The simultaneous testing of multiple markers predictive of response could help to identify more accurately the true role of these polymorphisms in CRC therapy. This review analyzes the role of genetic variants in genes involved in the action mechanisms of the drugs used at present in colorectal cancer. | Eva Bandrés Ruth Zárate Natalia Ramirez Ana Abajo Nerea Bitarte Jesus García-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 3 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 4 | Coronary physiology assessment in the catheterization laboratory显示文摘Physicians cannot rely solely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischemia. Instead, sound knowledge of coronary vascular physiology and of the methods currently available for its characterization can improve the diagnostic and prognostic accuracy of invasive assessment of the coronary circulation, and help improve clinical decision-making. In this article we summarize the current methods available for a thorough assessment of coronary physiology. | Felipe Díez-delhoyo Enrique Gutiérrez-Ibanes Gerard Loughlin Ricardo Sanz-Ruiz María Eugenia Vázquez-álvarez Fernando Sarnago-Cebada Rocío Angulo-Llanos Ana Casado-Plasencia Jaime Elízaga Francisco Fernández Avilés Diáz | 2015 | World Journal of Cardiology2015，7，9： | 2 |
| 5 | Multiagent architecture for intelligent trafficmanagement systems显示文摘 | Josefa Z Hernandez Sascha Ossowski Ana Garcia Ser-rano | 2002 | Transportation ResearchPart C:Emerging Technologies2002，10，56： | 1 |
| 6 | Multiagent architecture for intellegent traffic management systems显示文摘 | OSSOWAKI Sascha GARCIA-SERRANO Ana | 2002 | Transportation Research Part C2002，10，： | 1 |
| 7 | Geographical indications,terroir,socioeconomic and ecological sustainability:The case of tequila显示文摘 | Sarah B Ana V Z | | 0，，25： | 1 |
| 8 | A vehicle routing algorithm for the distribution of fresh vegetables and similar perishable food显示文摘 | Lidija Z S Ana O | 2008 | Journal of Food Engineering2008，85，： | 1 |
| 9 | Optimizationof J3-glucosidase, |3-xylosidase and xylanase produc-tion by colletotrichum graminicoLa under solid-statefermentation and application in raw sugarcane trashsaccharification 显示文摘 | Ana L R L Z Cesar S?Luana P M | 2013 | Int J Mol Sci2013，14，2： | 1 |
| 10 | A muhivariate Kolmogorov - Smimov test of goodness of fit 显示文摘 | Ana J Daniel P Rubm Z | 1997 | Statistics and Probability Letters1997，35，： | 1 |
| 11 | SCA2 trinucleotide expansion in German SCA patients显示文摘 | Olaf Riess Franco A. Laccone Suzana Gispert Ludger Sch?ls Christine Zühlke Ana Maria Menezes Vieira-Saecker Susanne Herlt Karl Wessel J?rg T. Epplen Bernhard H.F. Weber Friedmar Kreuz Soheyla Chahrokh-Zadeh Alfons Meindl Astrid Lunkes Jorge Aguiar Milan M | 1997 | Neurogenetics1997，，1： | 1 |
| 12 | Embryonic neural stem cells in a 3D bioassay for trophic stimulation studies显示文摘 | Ana Maria Cruz Gaitán Nadia Magali Torres-Ruíz Néstor Gabriel Carri | 2015 | Brain Research Bulletin2015，，： | 1 |
| 13 | Clashing metaphors about classroom teachers: toward a systematic typology for the language teaching field显示文摘 | Rebecca L Oxford Stephen Tomlinson Ana Barcelos Cassandra Harrington Roberta Z Lavine Amany Saleh Ana Longhini | 1998 | System1998，，1： | 1 |
| 14 | Real-time traffic information for emergency evacuations显示文摘 | OSCAR F LI Z ANAS M | 2010 | Journal of Transportation Safety&Security2010，2，1： | 1 |
| 15 | Oxidative Stress Is not Related to the Mode of Action of Herbicides That Inhibit Acetolactate Synthase显示文摘 | ANA Z SUSANA G LUISA M S | 2007 | Environmental and Experimental Botany2007，59，2： | 1 |
| 16 | Aromatic compounds degradation plays a role in colonization of Arabidopsis thaliana and Acacia caven by Cupriaviduspinatubonensis JMP134显示文摘 | Thomas L Ana Z Tatiana K | 2012 | Antonie van Leeuwenhoek International Journal of General mid Molecular Microbiology2012，101，4： | 1 |
| 17 | Chemical composition and antibacterial activity of Cordia verbenacea extracts obtained by different methods显示文摘 | ELIANE M Z MICHIELIN ANA A SALVADOR CARLOS A S RIEHL | 2009 | Bioresource Technology2009，，100： | 1 |
| 18 | A multivariate Kolmogorov-Smimov test of goodness of fit显示文摘 | Ana J Daniel P Rubm Z | 1997 | Statisties and Probability Letters1997，35，： | 1 |
| 19 | Cylindrocarpon root rot:multi-gene analysis reveals novelspecies within the Ilyonectria radicicola,species complex显示文摘 | Cabral Ana Groenewald Johannes Z Rego Cecília | 2012 | Mycological Progress2012，11，3： | 1 |
| 20 | Correlation of different imaging modalities in pre-surgical evaluation of pericardial metastasis of liposarcoma显示文摘 | Zeljko Z Markovic Ana Mladenovic Marko Banovic Branislava Ivanovic | 2012 | Chinese Medical Journal2012，，20： | 1 |
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