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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Bioremediation in the rhizosphere 显示文摘 | Anderson TA Elizabeth AG Walton BT | 1993 | EnvironSciTechnol1993，27，13： | 1 |
| 3 | A pilot study of hyperbaric oxygen in the treatment of human stroke显示文摘 | Anderson DC Bottini AG Jagiella WM | 1991 | Stroke1991，22，： | 1 |
| 4 | Microbiologic assessment nf disposable sterile endoscopic sheaths to replace high-level disinfection in reprocessing: a prospective clinical trim with nasophaogoscopes 显示文摘 | Alvarado C J Anderson AG Maki DG | 2009 | Am J Infect Control2009，37，5： | 1 |
| 5 | Vitamin D actions to regulate calcium and skeletal homeostasis显示文摘 | Anderson PH Turner AG Morris HA | | 0，，： | 1 |
| 6 | IL-6-driven STAT signalling in circulating CD4+lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis显示文摘 | Anderson AE Pratt AG Sedhom MA | 2016 | Ann Rheum Dis2016，75，： | 1 |
| 7 | Anti - oxidative effects of theophylline on human neutrophils involve cyclic nucleotidea and protein kinase A显示文摘 | Mahomed AG Themn AJ Anderson R | 1998 | Inflammation1998，22，6： | 1 |
| 8 | Vitamin D metabolism within bone cells:effects on bone structure and strength显示文摘 | Anderson PH Atkins GJ Turner AG Kogawa M Findlay DM Morris HA | | 0，，： | 1 |
| 9 | The effect of thoracic kyphosis and sagittal plane alignment on vertebral compressive loading显示文摘 | Bruno AG Anderson DE D'Agostino J | 2012 | J Bone Miner Res2012，27，10： | 1 |
| 10 | Late fatigue fracture of a modern cemented cobalt chrome stem for total hip arthroplasty: a report of 10 cases显示文摘 | Della Valle AG Becksac B Anderson J | 2005 | J Arthroplasty2005，20，8： | 1 |
| 11 | Unusual molecular architecture of the Yersinia pestis cytotoxin YopM: a leucine-rich repeat protein with the shortest repeating unit显示文摘 | Evdokimov AG Anderson DE Routzahn KM | 2001 | J Mol Biol2001，312，4： | 1 |
| 12 | Gonadotropin-induced resumption of oocyte meiosis and meiosis-acrirating sterols显示文摘 | Anderson CY Baltsen M Byskov AG | 1999 | Curr Top Dev Biol1999，41，： | 1 |
| 13 | A pilot study of hyperbaric oxygen in the treatment of human stroke显示文摘 | Anderson DC Bottini AG Jagiella WM | 1991 | Stroke1991，22，： | 1 |
| 14 | The interleukin-1 family of cytokines and receptors in human breast cancer:implications for tumor progression显示文摘 | Pushkar I Anderson KH et a1 | 2003 | Int J Oncol2003，23，2： | 1 |
| 15 | The interleukin-1 family of cytokines and receptors in human breast cancer:implications for tumor progression显示文摘 | Pantschenko AG Pushkar I Anderson KH | 2003 | Int J Oncol2003，23，2： | 1 |
| 16 | A randomized,controlled,double-blind pilot study of the effects of cranial electrical stimulation on activity in brain pain processing re-gions in individuals with fibromyalgia显示文摘 | Taylor AG Anderson JG Riedel SL | 2013 | EXPLORE:The Journal of Science and Healing2013，9，1： | 1 |
| 17 | The false falx sign 显示文摘 | Osborn AG Anderson RE Wing SD | 1980 | Radiology1980，134，： | 1 |
| 18 | Extracllular fluid and total hohy water changes in neonates undergoing extracorporeal membrane oxygenation显示文摘 | Anderson HL Coran AG Drongowiski RA | 1992 | J Pediatr Surg1992，27，： | 1 |
| 19 | Computed tomography features of nonthroid extraocular muscle enlargement 显示文摘 | Patrinely JR Osborn AG Anderson RL | 1989 | Ophthalmology1989，96，： | 1 |
| 20 | Present treatment options for atrial fibrfillation显示文摘 | Lairikyengbam SK Anderson MH Davies AG | 2003 | Postgrad Med J2003，79，928： | 1 |
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