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| 1 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Unfrozen water contents of submarine permafrost determined by nuclear magnetic resonance 显示文摘 | Tice A R Anderson D M Sterrett K F | 1981 | Engineering Geology1981，18，： | 2 |
| 4 | In formation hiding a survey 显示文摘 | Petitcolas F A P Anderson R J Kulm M G | 1999 | IEEE Special Issue on Protection of Multimedia Content1999，87，7： | 1 |
| 5 | A parameter optimization approach for the optimal control of large-scale musculoskeletal systems 显示文摘 | Pandy M G Anderson F C | 1992 | J Bio Eng Trans of the ASME1992，114，11： | 1 |
| 6 | Current management of ALS : comparison of the ALS CARE Database and the AAN Practice Parameter显示文摘 | Bradley WG Anderson F Bromberg M | 2001 | Neurology2001，57，3： | 1 |
| 7 | Free radicals and ocular disease显示文摘 | ANDERSON R E KRETZER F L RAPP L M | 1994 | Adv Exp Med Biol1994，366，： | 1 |
| 8 | Information hiding-a survey显示文摘 | Petitcolas F A P Anderson R J Kuhn M G | 1999 | Proc of IEEE1999，87，7： | 1 |
| 9 | A construct-driven investigation of gender differences in a leadership-role assessment center显示文摘 | Anderson N Lievens F van Dam K Born M | | 0，，： | 1 |
| 10 | The severe and moderate phenotypes of heritable Mac-1,LAK-1deficiency; The quantitative definition and relation to leukocyte dysfunction and clinical feature显示文摘 | Anderson D C Schmalsteig F C Finegold M J | 1985 | J Infect Dis1985，152，4： | 1 |
| 11 | Information hiding-A survey 显示文摘 | F A P Petitcolas R J Anderson M G Kuhn | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 12 | Human microvascular endothelial cell growth and migration on biomimetic surfactant polymers 显示文摘 | Sagnella S M Kligman F Anderson E H | 2004 | Biomaterials2004，25，： | 1 |
| 13 | Patterns of cancer incidence, mortality, and prevalance across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world显示文摘 | Kamangar F Dores G M Anderson W F | 2006 | J Clin Oncol2006，24，14： | 1 |
| 14 | Information Hiding-A Survey显示文摘 | Petitcolas P F A P Anderson R J Kuhn M G | 1999 | Proceedings of the IEEE Special Issue on Protection of Multimedia Content1999，87，7： | 1 |
| 15 | Stable isotopes of oxygen and carbon and their application to sedimentologic and paleoenvironmental problems显示文摘 | ANDERSON T F ARTHUR M A | 1983 | SEPM Short Course1983，10，： | 1 |
| 16 | Prevalence of diastolic in normotensive,asymptomatic patients with well-controlled type 2 diabetes mellitus显示文摘 | ZABALGOITIA M ISMAEIL M F ANDERSON L | 2001 | Am J Cardiol2001，87，： | 1 |
| 17 | Information hiding-a survey显示文摘 | PETITCOLAS F ANDERSON R KUHN M | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 18 | Information hiding-a survey显示文摘 | Petitcolas F A P Anderson R J Kuhn M G | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 19 | Dietary intake of heterocyclic amines and henzo(a)pyrene:associations with pancreatic cancer显示文摘 | ANDERSON K E KADLUBAR F F KULLDORFF M | 2005 | Cancer Epidemiology Biomarkers Prevention2005，14，： | 1 |
| 20 | Characterization of a bright, tunable, ultrafast Comp- ton scattering X-ray source显示文摘 | HARTEMANN F V TREMAINE A M ANDERSON S G | 2004 | Laser and Particle Beams2004，22，3： | 1 |
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