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| 1 | Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies显示文摘Lung cancer is currently the leading cause of cancer death in Western nations.Non-small cell lung cancer(NSCLC)represents 80%of all lung cancers,and adenocarcinoma is the predominant histological type.Despite the intensive research carried out on this field and therapeutic advances,the overall prognosis of these patients remains unsatisfactory,with a 5-year overall survival rate of less than 15%.Nowadays,pharmacogenetics and pharmacogenomics represent the key to successful treatment.Recent studies suggest the existence of two distinct molecular pathways in the carcinogenesis of lung adenocarcinoma:one associated with smoking and activation of the K-Ras oncogene and the other not associated with smoking and activation of the epidermal growth factor receptor(EGFR).The K-ras mutation is mainly responsible for primary resistance to new molecules which inhibit tyrosine kinase EGFR(erlotinib and gefitinib)and most of the EGFR mutations are responsible for increased tumor sensitivity to these drugs.This article aims to conduct a systematic review of the literature regarding the molecular pathways involving the EGFR,K-Ras and EGFR targeted therapies in NSCLC tumor behavior. | Ramon Andrade de Mello Dania Sofia Marques Rui Medeiros António MF Araújo | 2011 | World Journal of Clinical Oncology2011，2，11： | 16 |
| 2 | Activation-induced T cell death exacerbates Trypanosoma cruzi replication in macrophages cocultured with CD4+ T lymphocytes from infected hosts显示文摘 | Nunes MP Andrade RM Lopes MF | 1998 | J Immunol1998，160，： | 1 |
| 3 | Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin显示文摘 | Pera MF Andrade J Houssami A | 2004 | J Cell Sci2004，117，7： | 1 |
| 4 | Renal failure is a risk factor for cefepime-induced encephalopathy显示文摘 | Garces EO Andrade de Anzambuja MF da Silva D | 2008 | J Nephrol2008，21，4： | 1 |
| 5 | Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin 显示文摘 | Pera MF Andrade J Houssami S | 2004 | J Cell Sci2004，117，7： | 1 |
| 6 | Renal failureis a risk factor for cefepime-induced encephalopathy显示文摘 | Garces EO Andrade de Anzambuja MF da Silva D | 2008 | J Nephrol2008，21，4： | 1 |
| 7 | Fatal acute hepatitisafter sequential treatment with levofloxacin,doxycycline,and naprox-en in a patient presenting with acute Mycoplasma pneumoniae infec-tion显示文摘 | Carrascosa MF Lucena MI Andrade RJ | 2009 | Clin Ther2009，31，： | 1 |
| 8 | The expression and functional characterization of abcg2 in brain endothelial cells and vessels 显示文摘 | Zhang W Mojsilovic-Petrovic J Andrade MF | 2003 | FASEB J2003，17，14： | 1 |
| 9 | Effects of phytoestrogens derived from soy bean on expression of adhesion molecules on HUVEC显示文摘 | Andrade CM Sd MF Toloi MR | 2012 | Climacteric2012，15，2： | 1 |
| 10 | Renal failure is a risk factor for cefepime-induced encephalopathy显示文摘 | Garces EO Andrade de Anzambuja MF da Silva D | 2008 | J Nephrol2008，21，4： | 1 |
| 11 | Renal failure is a risk factor for cefepime-induced encephalopathy显示文摘 | Garces EO Andrade de Anzambuja MF da Silva D | 2008 | J Nephrol2008，21，4： | 1 |
| 12 | Role of peritubular capillaries and vascular endothelial growth factor in chronic allograft nephropathy显示文摘 | Modelli de Andrade LG Viero RM Carvalho MF | | 0，，： | 1 |
| 13 | Adenoid cystic carcinoma of the maxillary sinus:a clinical-pathological report of10 years of experience from a single institution显示文摘 | Andrade MF de Faria PR Cardoso SV | 2014 | Int J Oral Maxillofac Surg2014，43，： | 1 |
| 14 | Fatal acute hepatitis after sequential treatment with levofloxacin, doxycycline,and naproxen in a patient presenting with acute mycoplasma pneumoniae infection显示文摘 | CARRASCOSA MF LUCENA MI ANDRADE RJ | 2009 | Clin Ther2009，31，5： | 1 |
| 15 | Renal failure is a risk factor for cefepime-induced encephalopathy显示文摘 | EO Garces Andrade de Anzambuja MF da Silva D | 2008 | JNephrol2008，21，4： | 1 |
| 16 | Insulin-like growth factor binding protein-4(IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP(dB-cAMP)-differentiated glioblastoma cells显示文摘 | Moreno MJ Ball M Andrade MF | 2006 | Glia2006，53，8： | 1 |
| 17 | Resistance to maxillary premolar fractures after restoration of class Ⅱ preparations with resin composite or ceromer显示文摘 | de Freitas CR Miranda MI de Andrade MF | 2002 | Quintessence Int2002，33，8： | 1 |
| 18 | Fatal acute hepatitis after sequentil treatment with levof loxacin, doxycycline, and naprox- cnina patient presenting with acute Mycoplasma pneumoniae infoc- tion显示文摘 | Carrascosa MF Lucena MI Andrade RJ | 2009 | ClinTher2009，31，： | 1 |
| 19 | The expression and functional characterization of ABCG2 in brain endothelial cells and vessels 显示文摘 | Zhang W Mojsilovic-Petrovic J Andrade MF | 2003 | FASEB J2003，17，14： | 1 |
| 20 | Effects of phytoestrogens derived from soy bean on expression of adhesion molecules on HUVEC 显示文摘 | Andrade CM $6 MF Toloi MR | 2012 | Climacteric2012，15，2： | 1 |
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