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您的检索式：作者名="Andrade VL"
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| 1 | Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress显示文摘AIM To evaluate the therapeutic effects of bone marrowderived CD11b+CD14+ monocytes in a murine model of chronic liver damage. METHODS Chronic liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry,biochemical assessment,immunohistochemistry and enzyme-linked immunosorbent assay. RESULTS CD11b+CD14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines,including tumor necrosis factor-α,interleukin(IL)-6 and IL-1β,in addition to pro-fibrotic factors,such as IL-13,transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased,while IL-10 and matrix metalloproteinase-9 increased in the monocytetreated group. CD11b+CD14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and osteopontin. CONCLUSION Monocyte therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation,as well as increasing antifibrogenic factors. | Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes D’assuncao Andreia Ferreira de Barros Camila Lima Carvalho Virgínia Maria Barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira | 2017 | World Journal of Gastroenterology2017，23，28： | 6 |
| 2 | Homocysteine and nitrite levels are modulated by MTHFR polymorphism in obese women treated with simvastatin显示文摘 | Villela MP Andrade VL Eccard B | 2014 | Clin Exp Pharmacol Physiol2014，41，10： | 1 |
| 3 | p53, estrogen and progesterone receptors in diagnostic curettage for endometrlal adenocarcinoma and their correlation with morphological data and disease stage at hysterectomy显示文摘 | Bonfitto VL de Angelo Andrade LA | 2003 | Sao Paulo Med J2003，121，4： | 1 |
| 4 | Simvastatin therapy decreases MMP-9 levels in obese women 显示文摘 | Andrade VL do Valle IB Sandrim VC | 2013 | J Clin Phar- maco12013，53，10： | 1 |
| 5 | Functionalpolymorphism located in MMP-9 gene promoter is strongly associated with obesity显示文摘 | Andrade VL Fernandes KS Bosco AA | 2012 | DNA Cell Biol2012，31，6： | 1 |
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