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| 1 | Hepatic ischemic preconditioning increases portal vein flow in experimental liver ischemia reperfusion injury显示文摘BACKGROUND: Ischemic preconditioning(IPC) has been shown to decrease liver injury and to increase hepatic microvascular perfusion after liver ischemia reperfusion. This study aimed to evaluate the effects of IPC on hemodynamics of the portal venous system. METHODS: Thirty-two rats were randomized into two groups: IPC group and control group. The rats of the IPC group underwent IPC by 10 minutes of liver ischemia followed by 10 minutes of reperfusion before liver ischemia, and the rats of the control group were subjected to 60 minutes of partial liver ischemia. Non-ischemic lobes were resected immediately after reperfusion. The animals were studied at 4 hours and 12 hours after reperfusion. Mean arterial pressure, heart rate, portal vein flow and pressure were analyzed. Blood was collected for the determination of the levels of aspartate aminotransferase, alanine aminotransferase, calcium, lactate, pH, bicarbonate, and base excess. RESULTS: IPC increased the mean portal vein flow at 4 hours and 12 hours after reperfusion. IPC recovered 78% of the meanportal vein flow at 12 hours after reperfusion. IPC decreased the levels of aspartate aminotransferase, alanine aminotransferase and lactate, and increased the levels of ionized calcium, bicarbonate and base excess at 12 hours after reperfusion. CONCLUSIONS: This study demonstrated that IPC increases portal vein flow and enhances hepatoprotective effects in liver ischemia reperfusion. The better recovery of portal vein flow after IPC may be correlated with the lower levels of transaminases and with the better metabolic profile. | Estela RR Figueira Joel A Rocha-Filho Mauro Nakatani Marcelo FS Buto Eduardo R Tatebe Vitor O Andre Ivan Cecconello Luiz AC D'Albuquerque | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 6 |
| 2 | Expression of the receptor protein tyrosine kinase myk-1/htk in normal andmalignant mammary epithelium 显示文摘 | Berclaz G Andres AC Albrecht D | 1996 | Biochem Biophys ResCommun1996，226，3： | 1 |
| 3 | Coal Desulphurization with Hydroiodic Acid and Microwaves 显示文摘 | Ferrando AC Andres JM Membrado L | 1995 | Coal Science and Technology1995，，24： | 1 |
| 4 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 5 | Molecular characterization of the murine Syk protein tyrosine kinase cDNA, transcripts and protein显示文摘 | Fluck M Zurcher G Andres AC | 1995 | Biochem Biophys Res Commun1995，213，： | 1 |
| 6 | Expression of the receptor pro- tein tyrosine kinase myk-1/htk in normal and malignant mammary epi- thelium 显示文摘 | Berclaz G Andres AC Albrecht D | 1996 | Biochemical Biophysical Research Communications1996，226，3： | 1 |
| 7 | Molecular characteriza- tion of the murine syk protein tyrosine kinase cDNA, transripts and protein显示文摘 | Fluck M Zuvcher G Andres AC | 1995 | Biochem Biophys Res Commun1995，213，1： | 1 |
| 8 | Cardiac glycosides initiate Apo2L/ TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5显示文摘 | Frese S Frese-Schaper M Andres AC | 2006 | Cancer Res2006，66，11： | 1 |
| 9 | Molecular characterization of the murine Syk protein tyrosine kinase cDNA,transcripts and protein显示文摘 | Fluck M Zurcher G Andres AC | 1995 | Biochem Biophys Res Gommun1995，213，1： | 1 |
| 10 | Expression of the reeeptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium显示文摘 | Berclaz G Andres AC Albrecht D | 1996 | Biochem Biophys Res Commun1996，226，3： | 1 |
| 11 | Radiographic detection of mobilizable lung water:the gravitational shift test 显示文摘 | Zimmerman JE Goodman LR St Andre AC | 1982 | AJR Am J Roentgenol1982，138，1： | 1 |
| 12 | Expression of the receptor protein tyrosine kinase myk-1/htk in normal and malignant mammary epithelium 显示文摘 | Berclaz G Andres AC Albrecht D | 1996 | Biochem biophys Res Commun1996，226，3： | 1 |
| 13 | Cardiac glycosides initiate APO2L/TRAIL induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5 显示文摘 | Frese S Frese-Schaper M Andres AC | 2006 | Cancer Res2006，66，： | 1 |
| 14 | Expression of to novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis显示文摘 | Andres AC Reid HH Blaschke RJ | 1994 | Oncogene1994，9，5： | 1 |
| 15 | Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland de- velopment and carcinogenesis 显示文摘 | Andres AC Reid HH Blaschke R J | 1994 | Oncogene1994，9，5： | 1 |
| 16 | 显示文摘 | Andres AC Groner B | 1988 | EMBO J1988，7，3： | 1 |
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