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| 1 | Global secretome analysis identifies novel mediators of bone metastasis显示文摘骨头是稳固的肿瘤的远转移的一个最普通的地点。分泌蛋白质被知道影响在变形癌症房间和骨头基质之间的病理学的相互作用。为了包括地介绍,分泌了与骨头转移联系的蛋白质,我们使用了量、非量的集体 spectrometry 全球性分析改变从多重种类和癌症的变形能力打的骨头的九根细胞线的 secretomes。由比较父母房间和他们的骨头的 secretomes 变形衍生物,我们识别了特别地在这些房间线与骨头转移被联系的分泌蛋白质。我们然后合并了大临床的转移数据集的生物信息的分析获得强烈与临床、试验性的骨头转移被联系的几个功能的班的候选人小说骨头转移蛋白质的一张表。选择蛋白质的功能的确认显示在 vivo,骨头转移能被高表示支持(1 ) 唾液的 cystatins CST1, CST2,和 CST4;(2 ) plasminogen 使活跃之物小块地和 PLAU;或(3 ) 骨胶原功能蛋白质 PLOD2 和 COL6A1。总的来说,我们的学习揭开了骨头转移并且因此的几个新分泌调停人证明 secretome 分析是为新奇 biomarkers 和候选人的鉴定的一个强大的方法治疗学的目标。 | Maria Andres Blanco Gary LeRoy Zia Khan Ma a Ale kovi Barry M Zee Benjamin A Garcia Yibin Kang | 2012 | Cell Research2012，22，9： | 12 |
| 2 | Different risk factors influence peptic ulcer disease development in a Brazilian population显示文摘AIM: To investigate age, sex, histopathology and Helicobacter pylori (H. pylori) status, as risk factors for gastroduodenal disease outcome in Brazilian dyspeptic patients.tients submitted to upper gastroscopy at Hospital das Clinicas of Marilia, antral biopsy specimens were obtained and subjected to histopathology and H. pylori diagnosis. All patients presenting chronic gastritis (CG) and peptic ulcer (PU) disease localized in the stomach, gastric ulcer (GU) and/or duodenal ulcer (DU) were included in the study. Gastric biopsies (n = 668) positive for H. pylori by rapid urease test were investigated for vacuolating cytotoxin A (vacA ) medium (m) region mosaicism by polymerase chain reaction. Logistic regression analysis was performed to verify the association of age, sex, histopathologic alterations, H. pylori diagnosis and vacA m region mosaicism with the incidence of DU, GU and CG in patients. RESULTS: Of 1466 patients submitted to endoscopy, 1060 (72.3%) presented CG [male/female = 506/554; mean age (year) ± SD = 51.2 ± 17.81], 88 (6.0%) presented DU [male/female = 54/34; mean age (year) ± SD = 51.4 ± 17.14], and 75 (5.1%) presented GU [male/female = 54/21; mean age (year) ± SD = 51.3 ± 17.12] and were included in the comparative analysis. Sex and age showed no detectable effect on CG incidence (overall c 2 = 2.1, P = 0.3423). Sex [Odds ratios (OR) = 1.8631, P = 0.0058] but not age (OR = 0.9929, P = 0.2699) was associated with DU and both parameters had a highly significant effect on GU (overall c 2 = 30.5, P < 0.0001). The histopathological results showed a significant contribution of ageing for both atrophy (OR = 1.0297, P < 0.0001) and intestinal metaplasia (OR = 1.0520, P < 0.0001). Presence of H. pylori was significantly associated with decreasing age (OR = 0.9827, P < 0.0001) and with the incidence of DU (OR = 3.6077, P < 0.0001). The prevalence of m1 in DU was statistically significant (OR = 2.3563, P = 0.0018) but not in CG (OR = 2.678, P = 0.0863) and GU (OR = 1.520, P = 0.2863). CONCLUSION: In our population, male gender was a risk factor for PU; ageing for GU, atrophy and metapla-sia; and H. pylori of vacA m1 genotype for DU. | Rodrigo Buzinaro Suzuki Rodrigo Faria Cola Larissa Tranquilino Bardela Cola Camila Garcia Ferrari Fred Ellinger Altino Luiz Therezo Luis Carlos da Silva André Eterovic Márcia Aparecida Sperana | 2012 | World Journal of Gastroenterology2012，18，38： | 8 |
| 3 | Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis显示文摘 | Juan A.del Olmo Andrés Pe?a Miguel A Serra Abdallah H Wassel Adolfo Benages José M Rodrigo | 2000 | Journal of Hepatology2000，，1： | 2 |
| 4 | Liquid-liquid extraction of biomolecules: an overview and update of the main techniques 显示文摘 | Priscila G Mazzola Andre M Lopes Francislene A Hasmann | 2008 | Journal of Chemical Technology and Biotechnology2008，83，2： | 1 |
| 5 | Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation 显示文摘 | Morales JM Andres A Rengel M | 2003 | Nephrel Dial Transplant2003，18，1： | 1 |
| 6 | Renal function with enteric-coated mycophenolate sodium in combination with reduced and standard tacrolimus levels: results of a 6-month comparative study in de novo renal transplant recipients显示文摘 | Hart M Chan L Andres A | 2008 | Am J Transplant2008，8，58： | 1 |
| 7 | Refractometric sen- sor based on whispering gallery modes of thin capillaries 显示文摘 | Zamora V Diez A Andres M V | 2007 | Optics Express2007，15，12： | 1 |
| 8 | Polygodial-induced noradrenaline release in human neuroblastoma SH-SYSY cells 显示文摘 | Andres M I Forsby A Walum E | 1997 | Toxicology in Vitro1997，11，： | 1 |
| 9 | A novelcyclic hexapeptide as chiral selector:application for HPLC separationof a series of dansyl amino and arylal- kanoic acids 显示文摘 | ANDRE C THOMASIN M UMRAYAMI A | 2007 | Talanta2007，71，4： | 1 |
| 10 | The yeast ammonium transport protein Mep2 and its positive regulator, the Nprl kinase, play an important role in normal and pscudohyphal growth on various nitrogen media through retrieval of excreted ammonium 显示文摘 | Boeckstaens M Andre B Marini A M | 2007 | Mol Microbiol2007，64，： | 1 |
| 11 | Overexpression of h-prune in breast cancer is correlated with advanced disease status显示文摘 | Zollo M Andre A Cossu A | 2005 | Clin Cancer Res2005，11，1： | 1 |
| 12 | Observations of Slow Electron Holes at a Magnetic Reconnection Site 显示文摘 | KHOTYAINTSEV Yu V VAIVADS A ANDRE M | 2010 | Phys Rev Lett2010，105，16： | 1 |
| 13 | The SAPHO syndrome: a clinical and imaging study 显示文摘 | Salles M Olive A Perez - Andres R | 2011 | ClinRheumatol2011，30，2： | 1 |
| 14 | Liquid phase hydrogenation of cinnamaldehyde on Cu-based catalysts 显示文摘 | Alberto J M Diego A G Andres F T | 2003 | Applied Catalysis A : General2003，249，： | 1 |
| 15 | Validated analytical strategy for the determination of polycyclic aromatic compounds in marine sediments by liquid chromatography coupled with diode-array detection and mass spectrometry 显示文摘 | GONZALEZ-PINUELA C ALONSO-SALCES R M ANDRES A | 2006 | J Chromatogr A2006，1129，2： | 1 |
| 16 | Cloning and expression of the MEP1 gene encoding an ammonium transporter of Saccharomyces cerevisiae显示文摘 | Marini A M Vissers S Urrestarazu A Andre B | 1994 | EMBO J1994，13，15： | 1 |
| 17 | Depth electrode recorded ceredbral responses with deepbrain stimulation of the anterior thalamus for epilepsy 显示文摘 | Dominik Zumsteg Andres M Lozano Richard A Wennberg | 2006 | Clinical Neurophysiology2006，117，： | 1 |
| 18 | Analysis of 13000 unique citrus clusters associated with fruit quality ,production and salinity tolerance显示文摘 | TEROL J CONESA A COLMENERO J CERCOS M TADEO F AGUSTI J ALOS E ANDRES F SOLER G BRUMOS J IGLESIAS D GOTZ S LEGAZ F ARGOIUT X COURTOIS B OLLITRAULT P DOSSART C WINCKER P MORILLON R TALON M | 2007 | BMC Genomics2007，8，： | 1 |
| 19 | Furfural production from corn cobs autohydrolysis liquors by microwave technology显示文摘 | Sánchez C Serrano L Andres M A | 2013 | Industrial Crops and Products2013，42，： | 1 |
| 20 | Mesial temporal inhibition in a patient with deep brain stimulation of the anterior thalamus for epilepsy 显示文摘 | Dominik Zumsteg Andres M Lozano Richard A Wennberg | 2006 | Epilepsia2006，47，11： | 1 |
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