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| 1 | Pathological aspects of so called 'hilar cholangiocarcinoma'显示文摘Cholangiocarcinoma(CC) arising from the large intrahepatic bile ducts and extrahepatic hilar bile ducts share clinicopathological features and have been called hilar and perihilar CC as a group.However,'hilar and perihilar CC' are also used to refer exclusively to the intrahepatic hilar type CC or,more commonly,the extrahepatic hilar CC.Grossly,a major distinction can be made between papillary and non-papillary tumors.Histologically,most hilar CCs are well to moderately differentiated conventional type(biliary) carcinomas.Immunohistochemically,CK7,CK20,CEA and MUC1 are normally expressed,being MUC2 positive in less than 50% of cases.Two main premalignant lesions are known:biliary intraepithelial neoplasia(BilIN) and intraductal papillary neoplasm of the biliary tract(IPNB).IPNB includes the lesions previously named biliary papillomatosis and papillary carcinoma.A series of 29 resected hilar CC from our archives is reviewed.Most(82.8%) were conventional type adenocarcinomas,mostly well to moderately differentiated,although with a broad morphological spectrum;three cases exhibited a poorly differentiated cell component resembling signet ring cells.IPNB was observed in 5(17.2%),four of them with an associated invasive carcinoma.A clear cell type carcinoma,an adenosquamous carcinoma and two gastric foveolar type carcinomas were observed. | Víctor M Castellano-Megías Carolina Ibarrola-de Andrés Francisco Colina-Ruizdelgado | 2013 | World Journal of Gastrointestinal Oncology2013，5，7： | 8 |
| 2 | Transcranial direct current stimulation in psychiatric disorders显示文摘The interest in non-invasive brain stimulation techniques is increasing in recent years. Among these techniques, transcranial direct current stimulation(t DCS) has been the subject of great interest among researchers because of its easiness to use, low cost, benign profile of side effects and encouraging results of research in the field. This interest has generated several studies and randomized clinical trials, particularly in psychiatry. In this review, we provide a summary of the development of the technique and its mechanism of action as well as a review of the methodological aspects of randomized clinical trials in psychiatry, including studies in affective disorders, schizophrenia, obsessive compulsive disorder, child psychiatry and substance use disorder. Finally,we provide an overview of t DCS use in cognitive enhancement as well as a discussion regarding its clinical use and regulatory and ethical issues. Although many promising results regarding t DCS efficacy were described, the total number of studies is still low, highlighting the need of further studies aiming to replicate these findings in larger samples as to provide a definite picture regarding t DCS efficacy in psychiatry. | Gabriel Tortella Roberta Casati Luana V M Aparicio Antonio Mantovani Natasha Senco Giordano D’Urso Jerome Brunelin Fabiana Guarienti Priscila Mara Lorencini Selingardi Débora Muszkat Bernardo de Sampaio Pereira Junior Leandro Valiengo Adriano H Moffa Marcel Simis Lucas Borrione André R Brunoni | 2015 | World Journal of Psychiatry2015，5，1： | 6 |
| 3 | Pathological features and diagnosis of intraductal papillary mucinous neoplasm of the pancreas显示文摘Intraductal papillary mucinous neoplasm(IPMN) of the pancreas is a noninvasive epithelial neoplasm of mucinproducing cells arising in the main duct(MD) and/or branch ducts(BD) of the pancreas.Involved ducts are dilated and filled with neoplastic papillae and mucus in variable intensity.IPMN lacks ovarian-type stroma,unlike mucinous cystic neoplasm,and is defined as a grossly visible entity(≥ 5 mm),unlike pancreatic intraepithelial neoplasm.With the use of high-resolution imaging techniques,very small IPMNs are increasingly being identified.Most IPMNs are solitary and located in the pancreatic head,although 20%-40% are multifocal.Macroscopic classification in MD type,BD type and mixed or combined type reflects biological differences with important prognostic and preoperative clinical management implications.Based on cytoarchitectural atypia,IPMN is classified into low-grade,intermediategrade and high-grade dysplasia.Based on histological features and mucin(MUC) immunophenotype,IPMNs are classified into gastric,intestinal,pancreatobiliary and oncocytic types.These different phenotypes can be observed together,with the IPMN classified according to the predominant type.Two pathways have been suggested:gastric phenotype corresponds to less aggressive uncommitted cells(MUC1-,MUC2-,MUC5 AC +,MUC6 +) with the capacity to evolve to intestinal phenotype(intestinal pathway)(MUC1-,MUC2 +,MUC5 AC +,MUC6- or weak +) or pancreatobiliary /oncocytic phenotypes(pyloropancreatic pathway)(MUC1 +,MUC 2-,MUC5 AC +,MUC 6 +) becoming more aggressive.Prognosis of IPMN is excellent but critically worsens when invasive carcinoma arises(about 40% of IPMNs),except in some cases of minimal invasion.The clinical challenge is to establish which IPMNs should be removed because of their higher risk of developing invasive cancer.Once resected,they must be extensively sampled or,much better,submitted in its entirety for microscopic study to completely rule out associated invasive carcinoma. | Víctor M Castellano-Megías Carolina Ibarrola-de Andrés Guadalupe López-Alonso Francisco Colina-Ruizdelgado | 2014 | World Journal of Gastrointestinal Oncology2014，6，9： | 4 |
| 4 | Localization and reactivity of an immunodominant domain in the NS3 region of hepatitis C virus 显示文摘 | Hendrik C André V Wilfried M | 1995 | Med Virol1995，45，： | 2 |
| 5 | Safety and efficacy of an early deambulation protocol after PTCA with an angio-seal device显示文摘 | ANDRE M L GOICOLEA J ARGIBAY V | 2001 | Rev Esp Cardiol2001，54，11： | 2 |
| 6 | Cell Therapy Based on Adipose Tissue-Derived Stromal Cells Promotes Physiological and Pathological Wound Healing显示文摘 | T G. Ebrahimian F Pouzoulet C Squiban V Buard M André B Cousin P Gourmelon M Benderitter L Casteilla R Tamarat | 2009 | Arteriosclerosis, Thrombosis, and Vascular Biology2009，，4： | 2 |
| 7 | Refractometric sen- sor based on whispering gallery modes of thin capillaries 显示文摘 | Zamora V Diez A Andres M V | 2007 | Optics Express2007，15，12： | 1 |
| 8 | Polyethylene wear debris and long-term clinical failure of the Charite disc prosthesis: A study of 4 patients 显示文摘 | Andre V O Steven M Filip S | 2007 | Spine2007，32，2： | 1 |
| 9 | Observations of Slow Electron Holes at a Magnetic Reconnection Site 显示文摘 | KHOTYAINTSEV Yu V VAIVADS A ANDRE M | 2010 | Phys Rev Lett2010，105，16： | 1 |
| 10 | Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells显示文摘 | Planat-Benard V Menard C Andre M | 2004 | Circ Res2004，94，2： | 1 |
| 11 | Strategies for recovering inhibition caused by long chain fatty acids on anaerobic thermophilic biogas reactors显示文摘 | Palatsi J Laureni M Andres M V | 2009 | Bioresource Technology2009，100，： | 1 |
| 12 | Spontaneous cardiomyocyte differentiation from adipose tissue stroma ceils 显示文摘 | PLANAT-BENARD V MENARD C ANDRE M | 2004 | Circ Res2004，94，2： | 1 |
| 13 | Malignancies after renal transplantation during 33 years at a single center显示文摘 | Gyula Végs? Maria Tóth Márta Hídvégi éva Toronyi Robert Mlanger Elek Dinya András Tóth Ferenc Perner Jen? Járay | 2007 | Pathology & Oncology Research2007，，1： | 1 |
| 14 | Fiber Bragg grating tuned and chirped using magnetic fields显示文摘 | Cruz J L Diez A Andres M V | 1997 | Electron Lett1997，33，3： | 1 |
| 15 | Mi- crowave-photonic frequency multiplication utilizing optical four-wavemixing and fiber Bragg gratings 显示文摘 | Wiberg A Perez-Millan P Andres M V | 2006 | J Lightw Technol2006，24，1： | 1 |
| 16 | Spontaneous cardiomyocyte differentiation from adipose tissue stroma cells 显示文摘 | Planat-Benard V Menard C Andre M | 2004 | Circ Res2004，94，2： | 1 |
| 17 | Spontaneous cardiomyocyte differentiation from adipose tissue stromal cells显示文摘 | Planat-Bemard V Menard C Andre M | 2004 | Circ Res2004，94，2： | 1 |
| 18 | Impedance and modulus spectroscopy of ZnO varistors 显示文摘 | Andres V M West A R | 1997 | Journal of Electroceramics1997，1，2： | 1 |
| 19 | Fiber bragg gratings tuned and chirped using magnetic fields显示文摘 | Cruz J L Diez A Andres M V et al | 1997 | Electron Letters1997，33，3： | 1 |
| 20 | Sensitive determination of aliphatic amines in water by high-performance liquid chromatography with chemilu-minescence detection显示文摘 | LLORET S M LEGUA C M ANDRS J V | 2004 | J Chromatogr:A2004，1035，： | 1 |
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