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| 1 | Putting things in place for fertilization: discovering roles for importin proteins in cell fate and spermatogenesis显示文摘Importin 蛋白质原来通过原子毛孔在蛋白质运输为他们的中央角色被描绘,唯一的细胞内部的入口到原子核。这个重要函数必须紧被调整由抄写因素和另外的原子蛋白质控制存取到 genomic DNA,到完成细胞的行为影响的适当调整房间命运。调停 Importin 的 nucleocytoplasmic 运输依靠他们货物的特定的识别,与到不同、重叠的蛋白质子集的每 importin 绑定。importin 功能的知识关于三个关键发展系统实质地膨胀了:胚胎的干细胞,肌肉房间和细菌排队。自从为调整 nucleocytoplasmic 运输的潜力被建议贡献精子发生,在十年,我们和其它证明了进原子核的渡船抄写因素执行的 importins 另外的角色,它控制房间命运。这评论从哺乳动物的精子发生的研究介绍关键调查结果揭示男富饶和不孕由产生的潜在的新小径。germline 开始的这些研究照亮 importin 蛋白质在管理细胞的区别的新方法,经由指导到不同细胞内部的分隔空间并且由决定细胞的压力回答的蛋白质包括。 | Kate L Loveland Andrew T Major Romaly Butler Julia C Young David A Jan Yoichi Miyamoto | 2015 | Asian Journal of Andrology2015，17，4： | 3 |
| 2 | Lymphoepithelial cysts and cystic lymphangiomas: Underrecognized benign cystic lesions of the pancreas显示文摘AIM: To identify their diagnostic and prognostic clinical characteristics in a large series.METHODS: Retrospective review of clinicopathologic and imaging characteristics of patients diagnosed with lymphoepithelial cysts and cystic lymphangiomas of the pancreas at Massachusetts General Hospital.RESULTS: Twelve patients were identified between 1/1/1997 and 8/1/2007. Their median age was 55.5 years(range 19-78 years), and 6 were females. The le-sion was incidentally discovered in half of the patients.Contrast enhanced computed tomography demonstrat-ed that the cysts had thin walls, without calcifications, pancreatic duct dilation or pancreatic parenchyma inva-sion. Endoscopic ultrasound with fine needle aspiration(EUS/FNA) confirmed the diagnosis of a lymphoepithe-lial cyst in 3 patients, one of whom was spared an op-eration and continues to do well after 6 years. Eleven patients had a resection: 3 pancreaticoduodenecto-mies, 7 distal pancreatectomies, and 1 enucleation. The median size of the cysts was 3 cm(range 2-20 cm). At a median follow-up of 57 mo no recurrences or other pancreas-related conditions occurred.CONCLUSION: Lymphoepithelial cysts and cystic lymphangiomas of the pancreas can be diagnosed with a combination of contrast-enhanced computed tomog-raphy scans and EUS/FNA. If the lesion is asymptom-atic, an operation might be avoided. | Ioannis T Konstantinidis Avinash Kambadakone Onofrio A Catalano Dushyant V Sahani Vikram Deshpe David G Forcione Jennifer A Wargo Carlos Fernandez-del Castillo Keith D Lillemoe Andrew L Warshaw Cristina R Ferrone | 2014 | World Journal of Gastrointestinal Surgery2014，6，7： | 2 |
| 3 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 4 | Application ofcomputed global radiation for areas of high relief 显示文摘 | Williams L D Barry R G Andrews J T | 1972 | Journal of Applied Meteorology1972，，11： | 1 |
| 5 | Modern superabsorbent polymers显示文摘 | Fredric L Buchholz Andrew T Graham | 1996 | J of Chem Edu1996，73，6： | 1 |
| 6 | Performance of broilers in cages显示文摘 | Andrews L D Goodwin T L | 1973 | Poult Sci1973，52，： | 1 |
| 7 | Application of computed global radiation for areas of high relief显示文摘 | WILLIAMS L D BARRY R G ANDREWS J T | 1972 | Journal of Applied Meteorology1972，，11： | 1 |
| 8 | Investigation of benzene oxide in bone marrow and other tissues of F344 rats following metabolism of benzene in vitro and in vivo 显示文摘 | Andrew B L Karen YO C Suramya W Thomas A M Bernard T G Stephen M R | 1998 | Chemical Research in Toxicology1998，11，4： | 1 |
| 9 | Social inhibition modulates the effect of negative emotions on cardiac prognosis following pereutaneous coronary intervention in the drug-eluting stent era显示文摘 | Denollet J Pedersen S S Andrew T L | 2006 | Eur Heart2006，27，2： | 1 |
| 10 | Sr lattice clock at 110-J6 fractional uncertainty by remote optical evaluation with a Ca clock显示文摘 | ANDREW D L ZELEVINSKY T CAMPBELL G K | 2008 | Science2008，319，5871： | 1 |
| 11 | A computerized method of visual acuity testing显示文摘 | Roy W Beck Pamela S Moke Andrew H Turpin Frederick L Ferris John Paul SanGiovanni Chris A Johnson Eileen E Birch Danielle L Chandler Terry A Cox R.Clifford Blair Raymond T Kraker | 2003 | American Journal of Ophthalmology2003，，2： | 1 |
| 12 | Stabilization of thin films of pyrethrins and allethrin显示文摘 | Miskus R P Andrews T L | 1972 | J Agric Food Chem1972，20，： | 1 |
| 13 | Combinedeffect of packaging atmosphere and storage temperature ongrowth of Listeria monocy togenes on ready to-eat shrimp 显示文摘 | Rutherford T J Marshall D L Andrews L S | 2007 | Food Microbiology2007，24，8： | 1 |
| 14 | Simulation, fabrication and testing of Bulk Micromachined 6H-SiC High-g Piezoresistive Accelerometer 显示文摘 | Andrew R Atwelll Robert S Okojie Kevin T Kornegay Scott L Roberson Alain Beliveau | 2003 | Sensors and Actuators A: Physics (S0924-4247)2003，104，1： | 1 |
| 15 | Early management of severe traumatic brain injury显示文摘 | Jeffrey V Rosenfeld Andrew I Maas Peter Bragge M Cristina Morganti-Kossmann Geoffrey T Manley Russell L Gruen | 2012 | The Lancet2012，，9847： | 1 |
| 16 | Pharmaco-metabonomic phenotyping and personalized drug treatment 显示文摘 | T Andrew C John C L Olivier C | 2006 | Nature2006，440，7087： | 1 |
| 17 | Steroids are required for epidermal cell fate establishment in Arabidopsis roots显示文摘 | Kavitha T Kuppusamy Andrew Y Chen Jennifer L Nemhauser | 2009 | Proceedings of the National Academy of Sciences of the United States of America2009，，106： | 1 |
| 18 | Accelerated evolution of cyto- chrome b in simian primates:adaptive evolution in concert with other mito- zhondrial proteins? 显示文摘 | ANDREWS T D JERMIIN L S EASTEAL S | 1998 | Journal of Molecular Evolution1998，47，3： | 1 |
| 19 | Activity, function and gene regulation of the catalytic subunit of telomerase (hTERT) 显示文摘 | POOLE J C ANDREWS L G TOLLEFSBOL T O | 2001 | Gene2001，269，12： | 1 |
| 20 | Suicidal overdoses of psychotropic drugs by elderly in New York City:comparison with younger adults显示文摘 | Robert A Andrew L Kenneth T | 2011 | Psychiatry Research2011，188，3： | 1 |
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