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| 1 | FOXP3 + regulatory T cells and their functional regulation显示文摘FOXP3 + 规章的 T (Treg ) 房间在维持免疫系统的有免疫力的忍耐和动态平衡是批评的。位于稳定性,粘性和 Treg 房间的功能的活动下面的分子的机制很在最近的年里被学习了。这里,我们总结这些吸引人的调查结果,并且为自体免疫的疾病, graft-versus-host 疾病(GVHD ) 和癌症的治疗在 Treg 房间治疗期间提供卓见进他们的潜在的使用或操作。 | Zhiyuan Li Dan Li Andy Tsun Bin Li | 2015 | Cellular & Molecular Immunology2015，12，5： | 34 |
| 2 | 单细胞RNA测序揭露人FOXP3^+调节性T细胞稳定性的关键调控分子显示文摘T淋巴细胞的异质性和可塑性对于决定免疫应答至关重要.FOXP3的稳定表达通常是调节性T(Treg)细胞的分子特征,现已有研究报道在炎症条件下Treg表现出了异质性.然而,炎症与Treg细胞抑制活性之间的相互作用仍然难以捉摸.本文利用单细胞RNA测序研究了Treg细胞对促炎性细胞因子IL-6的响应.研究者观察到在IL-6刺激后Treg细胞分为两个亚群.TIGIT阴性的Treg细胞丢失了FOXP3基因的表达,获得了类似效应性T细胞的表型,而TIGIT阳性的Treg细胞则保留了较强的免疫抑制功能.本文还通过单细胞转录组分析揭示了IL-6刺激下Treg细胞的状态变化,以及CYP1A1作为Treg细胞抑制功能和稳定性的关键调控基因.CYP1A1缺陷型Treg细胞在IL-6刺激后出现类似Th17细胞的表型.本研究发现暗示CYP1A1作为Treg细胞的一个崭新的调节分子,具有潜在的生物治疗应用潜力. | 伊刚 赵毅 解丰 朱福香 万紫云 王婧琬 王谢 高开 曹丽霞 李新洋 陈辰 旷雅舒 邱秀 杨焕明 汪建 苏冰 陈磊 张伟 侯勇 徐讯 贺银燕 Andy Tsun 刘晓 李斌 | 2020 | Science Bulletin2020，65，13： | 7 |
| 3 | Treatment of postoperative infectious complications in patients with human immunodef iciency virus infection显示文摘BACKGROUND: Antibiotics are widely given for surgical patients to prevent infection. Because of the lack of study on the rational use of antibiotics in patients with human immunodef iciency virus(HIV)-infected during surgical procedures, we analyzed the risk factors affecting postoperative infectious complications in HIV-infected patients and explore the rational use of perioperative antibiotics.METHODS: This retrospective study consisted of 308 HIV-infected patients, 272 males and 36 females, who had undergone operation at the Shanghai Public Health Clinical Center from November 2008 to April 2012. The patients were divided into postoperative infection and non-infection groups. Their age and clinical variables were compared. The correlation between surgical incision, surgical site infection(SSI) and postoperative sepsis was analyzed. Prophylactic antibiotics were used for patients with type I and II incisions for less than 2 days. Patients with type III incisions were given antibiotics until the infection was controlled. Antiretroviral therapy(ART) was prescribed preoperatively for patients whose preoperative CD4 count was <350 cells/μL. For those patients whose preoperative CD4 count was <200 cells/μL, sulfamethoxazole and fluconazole were given preoperatively as prophylactic agents controlling Pneumocystis carinii pneumonia and fungal infection.RESULTS: A total of 196 patients developed postoperative infectious complications, and 7 patients died. Preoperative CD4 counts, ratio of CD4/CD8 cells, hemoglobin level, and postoperative CD4 counts, hemoglobin and albumin levels were risk factors of perioperative infection in HIV-infected patients. Patients with a preoperative CD4 count <200 cell/μL, anemia, a postoperative CD4 count <200 cell/μL or albumin levels <35 g/L were correlated with a higher rate of perioperative infection. There was a signif icant correlation between SSI and the type of surgical incision. The rate of SSI in patients with type I surgical incision was 2% and in those with type II surgical incision was 38%. All the patients who received type III surgical incision developed SSI, and they were more likely to develop postoperative sepsis.CONCLUSIONS: HIV-infected patients are more likely to develop postoperative infectious complications. The rational use of antibiotics in HIV-infected patients could help to reduce the rate of postoperative infectious complications in these patients. | Bao-chi Liu Lei Zhang Jin-song Su Andy Tsun Bin Li | 2014 | World Journal of Emergency Medicine2014，5，2： | 4 |
| 4 | Romance of the three kingdoms: RORgammat allies with HIF1alpha against FoxP3 in regulating T cell metabolism and differentiation显示文摘Regulatory T(Treg)cells play an essential role in immune homeostasis by controlling the function of various immune effector cells,including RAR-related orphan receptor gammat+(RORγt+)T helper 17(Th17)cells.Foekhead box P3(FoxP3)is the master regulator of Treg cell function,while RORγt is the key transcription factor for the induction of the interleukin(IL)-17 family of cytokines during Th17 cell differentiation.FoxP3 can directly interact with and negatively regulate the function of RORγt,to determine the balance between induced Treg(iTreg)and Th17 cell polarization.Two recent independent studies from the Pan and Chi Labs have shown how hypoxia-inducible factor 1 alpha(HIF1α)is able to tip the balance of T cell differentiation toward the Th17 lineage by responding to the local changes in metabolic shift or an increase in proinflammatory mediators in the microenvironment.By allying with HIF1α,RORγt wins the fight against FoxP3 and Treg cell commitment. | Andy Tsun Zuojia Chen Bin Li | 2011 | Protein & Cell2011，2，10： | 4 |
| 5 | Identification and functional analysis of heterogeneous FOXP3^+ Treg cell subpopulations in human pancreatic ductal adenocarcinoma显示文摘CD4^+CD25^+regulatory T(Treg) cells express the transcription factor FOXP3 and play an essential role in preventing autoimmunity. Abundant Treg cell accumulation in tumors and tumor draining lymph nodes(TDLNs) has been reported to correlate with both poor and favorable prognosis in various cancers, which suggests that Tregs may have multiple effects on antitumor immunity. However, the heterogeneity of tumor^-and TDLN^-infiltrating Treg cells remains unclear. Here we provide heterogeneity analysis of tumor infiltrating human CD4^+Treg cells and their matched adjacent tissues and TDLNs. We defined three different subpopulations of tumor^-and TDLN^-infiltrating Treg cells by Helios and CCR8 expression in pancreatic ductal adenocarcinoma(PDAC) and confirmed their functional heterogeneity. Helios^+CCR8^+Treg cells with potent suppressor function and limited IL^-2 and IFN^-c secretion were identified in tumors and TDLNs. On the contrary, Helios^-CCR8^-Treg cells have impaired suppressive activity, and elevated expression of pro^-inflammatory cytokines. More advanced grades of PDAC have predominantly Helios^+CCR8^+Treg cells and few Helios^-CCR8^-Treg cells both in tumors and TDLNs that suggests poor prognosis. These data could help further define the role of Treg cells and their functional role in tumors and TDLNs. | Gang Yi Shiwei Guo Wenyu Liu Huan Wang Rendong Liu Andy Tsun Gang Jin Bin Li | 2018 | Science Bulletin2018，63，15： | 3 |
| 6 | FOXP3 and RORγt: Transcriptional regulation of Treg and Th17显示文摘 | Zuojia Chen Fang Lin Yayi Gao Zhiyuan Li Jing Zhang Yue Xing Zihou Deng Zhengju Yao Andy Tsun Bin Li | 2010 | International Immunopharmacology2010，，5： | 2 |
| 7 | Understanding and therapeutically modulating the stability of regulatory T cells to treat inflammatory diseases显示文摘Forkhead box P3(FOXP3)^+regulatory T(Treg)cells are crucial for the homeostasis of the immune system,and harbor suppressive capacities of which are maintained by or inherited with distinct epigenetic signatures.The functional features of Treg cells are facilitated by multiple T cell differentiation-related transcription factors that therefore endow them with adaption capability to dynamic microenvironments.Recent studies also recalled the importance of immune cell metabolism,which is intimately linked with Treg cell differentiation,proliferation and function.Understanding the molecular mechanism underlying the functional stability of Treg cells could provide therapeutic opportunities to treat major human inflammatory diseases including infection,autoimmunity,allergy and cancer. | LI YangYang LI Dan WANG AiTing ZHU FuXiang Tsun Andy LI Bin | 2015 | Science Foundation in China2015，23，1： | 0 |
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