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| 1 | Chronic hepatitis C virus infection:Prevalence of extrahepatic manifestations and association with cryoglobulinemia in Bulgarian patients显示文摘AIM: To assess the prevalence of extrahepatic manifestations in Bulgarian patients with chronic hepatitis C virus (HCV) infection and identify the clinical and biological manifestations associated with cryoglobulinemia. METHODS: The medical records of 136 chronically infected HCV patients were reviewed to assess the prevalence of extrahepatic manifestations. Association between cryoglobulin-positivity and other manifestations were identified using χ2 and Fisher’s exact test. Risk factors for the presence of extrahepatic manifestations were assessed by logistic regression analysis. RESULTS: Seventy six percent (104/136) of the patients had at least one extrahepatic manifestation. Clinical manifestations included fatigue (59.6%), kidney impairment (25.0%), type 2 diabetes (22.8%), paresthesia (19.9%), arthralgia (18.4%), palpable purpura (17.6%), lymphadenopathy (16.2%), pulmonary fi brosis (15.4%), thyroid dysfunction (14.7%), Raynaud’s phenomenon (11.8%), B-cell lymphoma (8.8%), sicca syndrome (6.6%), and lichen planus (5.9%). The biological manifestations included cryoglobulinproduction (37.5%), thrombocytopenia (31.6%), and autoantibodies: anti-nuclear (18.4%), anti-smooth muscle (16.9%), anti-neutrophil cytoplasm (13.2%) and anti-cardiolipin (8.8%). All extrahepatic manifestations showed an association with cryoglobulin-positivity, with the exception of thyroid dysfunction, sicca syndrome, and lichen planus. Risks factors for the presence of extrahepatic manifestations (univariate analysis) were: age ≥ 60 years, female gender, virus transmission by blood transfusions, longstanding infection (≥ 20 years), and extensive liver fi brosis. The most signifi cant risks factors (multivariate analysis) were longstanding infection and extensive liver fi brosis. CONCLUSION: We observed a high prevalence of extrahepatic manifestations in patients with chronic HCV infection. Most of these manifestations were associated with impaired lymphoproliferation and cryoglobulin production. Longstanding infection and extensive liver fi brosis were signifi cant risk factors for the presence of extrahepatic manifestations in HCV patients. | Diana V Stefanova-Petrova Anelia H Tzvetanska Elisaveta J Naumova Anastasia P Mihailova Evgenii A Hadjiev Rumiana P Dikova Mircho I Vukov Konstantin G Tchernev | 2007 | World Journal of Gastroenterology2007，13，48： | 5 |
| 2 | Abundance and spatial dynamics of bacterioplankton in the Seven Rila Lakes,Bulgaria显示文摘In the high mountain oligotrophic Seven Rila Lakes (2 095–2 535 m a.s.l.) bacterial abundance was recorded in July and September 2006. In July, bacterial abundance (average (3.32±2.5)×105 cell/ml) in the lakes correlated negatively with elevation, while in September (average (26.39±7.1)×105 cell/ml) this pattern was altered and the greatest abundance of bacteria occurred at the highest ((39.05±1.5)×105 cell/ml) and the lowest ((30.63±6.0)×105 cell/ml) elevated lakes. Regression analyses suggested that the principal factor controlling bacterial abundance, in both July and September, was inorganic nitrogen (NO3-N and NH4-N; R2=0.70, P<0.05). Other major regulating factors were temperature (R2=0.66, P<0.03) in July and filter-feeding zooplankton (R2=0.95, P<0.01) in September. All factors, except NO3-N, had a positive effect on bacterial abundance. | Silvena BOTEVA Ivan TRAYKOV Anelia KENAROVA Valentin BOGOEV | 2010 | Chinese Journal of Oceanology and Limnology2010，28，3： | 2 |
| 3 | Community level physiological profiles of bacterial communities inhabiting uranium mining impacted sites显示文摘 | Anelia Kenarova Galina Radeva Ivan Traykov Silvena Boteva | 2013 | Ecotoxicology and Environmental Safety2013，，： | 2 |
| 4 | 查看详情显示文摘 | Anelia H | | 0，，： | 1 |
| 5 | Assessment of polysomaty, embryo formation and regeneration in liquid media for various species of diploid annual Medicago显示文摘 | Anelia Iantchevaa Mariana Vlahova Toan Hanh Trinh | 2001 | Plant Science2001，160，： | 1 |
| 6 | In Vivo I- dentification of Bipotential Adipocyte Progenitors Recruited by β3 -Adrenoceptor Activation and High-Fat Feeding 显示文摘 | Yun-Hee Lee Anelia P Petkova | 2012 | Cell2012，15，4： | 1 |
| 7 | On the Capacity Game of Public Watermarking Systems显示文摘 | Anelia Somekh-Baruch Neri Merhav | 2004 | IEEE Transactions on Information Theory2004，50，3： | 1 |
| 8 | Precursor B-cell lymphoblastic leukemia as a cause of a bilateral nephromegaly显示文摘 | Anelia Boueva Raymonde Bouvier | 2005 | Pediatric Nephrology2005，，5： | 1 |
| 9 | 保加利亚的苹果生产与研究显示文摘保加利亚气候条件非常适宜苹果生长。1968年保加利亚苹果种植面积为3.04万hm^2,但近年由于土地改革,苹果种植面积持续减少,现仅存5393hm^2。笔者介绍了目前保加利亚苹果的种植面积、产量、主栽品种、砧木、树形及研究状况。 | Atanas Blagov Venera Tasseva Efriyan Krishkov Maria Borovinova Dimitar Domozetov Iliyana Radomirska Anelia Zdravkova 李慧峰 秦志华 周润生 | 2007 | 落叶果树2007，39，6： | 0 |
| 10 | 保加利亚主要鲜食葡萄品种评价显示文摘保加利亚位于巴尔干半岛的东南部.属于温带气候.北部略受大陆性气候影响,南部带有地中海气候特点.气候和土壤等自然条件非常适宜葡萄种植.是世界著名的葡萄与葡萄酒生产国之一。长期以来.保加利亚的农业科研机构非常注重鲜食葡萄品种的选育研究. | Simeon Krumov Anelia Borosova Atanas Blagov 宋来庆 | 2012 | 烟台果树2012，，1： | 0 |
| 11 | Microalgae Improve the Photosynthetic Performance of Rice Seedlings(Oryza sativa L.)under Physiological Conditions and Cadmium Stress显示文摘The aim of this study was to assess the impact of the microalgae Chlorella vulgaris on the rice seedlings at physiological conditions and under cadmium(Cd)stress.We examined the effects of C.vulgaris in the nutrient solution on rice seedlings grown hydroponically in the presence and the absence of 150μM CdCl2,using the low(77 K)temperature and pulse amplitude modulated(PAM)chlorophyll fluorescence,P700 photooxidation measurements,photochemical activities of both photosystems,kinetic parameters of oxygen evolution,oxidative stress markers(MDA,H_(2)O_(2) and proline),pigment content,growth parameters and Cd accumulation.Data revealed that the application C.vulgaris not only stimulates growth and improves the functions of photosynthetic apparatus under physiological conditions,but also reduces the toxic effect of Cd on rice seedlings.Furthermore,the presence of the green microalgae in the nutrient solution of the rice seedlings during Cd exposure,signifi-cantly improved the growth,photochemical activities of both photosystems,the kinetic parameters of the oxygen-evolving reactions,pigment content and decreased lipid peroxidation,H_(2)O_(2) and proline content.Data showed that the alleviation of Cd-induced effects in rice seedlings is a result of the Cd sorption by microalgae,as well as the reduced Cd accumulation in the roots and its translocation from the roots to the shoots. | Ekaterina Yotsova Martin Stefanov Georgi Rashkov Margarita Kouzmanova Anelia Dobrikova Emilia Apostolova | 2022 | Phyton-International Journal of Experimental Botany2022，91，7： | 0 |
| 12 | 瑞芬太尼在无痛分娩中的应用显示文摘分娩镇痛所需的理想全身性镇痛药物应安全、有效、易于管理,起效与消除迅速,与子宫收缩的时间一致,且对胎儿没有影响。虽然椎管内麻醉是无痛分娩的“金标准”,但当椎管内麻醉存在禁忌、产妇不接受或临产时没有机会施行,或熟练操作的麻醉医生不在场时,就需要采用全身性镇痛。由于瑞芬太尼独特的药理学性质,其在临床上用于静脉无痛分娩得到了广泛研究。本文就瑞芬太尼用于无痛分娩的效果、剂量、分布、对产妇与胎儿或新生儿的安全性以及未来的研究范围等,进行了重点综述回顾。 | Anelia Hinova, FRCA Roshan Fernando, FRCA 魏义勇(译) | 2011 | 麻醉与镇痛2011，7，5： | 0 |
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