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| 1 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 2 | Total factor carbon e-mission performance; a malmquist index analysis显示文摘 | ZHOU P ANG B W HAN J Y | 2010 | En-ergy Economics2010，32，1： | 1 |
| 3 | Total factor carbon emission performance: a malmquist index analysis显示文摘 | Zhou P Ang B W Han J Y | 2010 | Energy Economics2010，32，1： | 1 |
| 4 | CO2 Emissions, Energy Consumption, and Output in France 显示文摘 | ANG J B | 2007 | Energy Policy2007，，35： | 1 |
| 5 | Total Factor Carbon Emission Per-formance :A Malmquist Index Analysis 显示文摘 | Zhou P Ang B W Han J Y | 2010 | Enei^y Economics2010，32，1： | 1 |
| 6 | CO2 emissions, research and technology trans- fer in China 显示文摘 | ANG J B | 2009 | Ecological Economics2009，68，5： | 1 |
| 7 | Financial reforms,patent protection,and knowledge accumulation in India显示文摘 | ANG J B | 2010 | World Development2010，38，8： | 1 |
| 8 | CO2 emissions, energy consumption, and output in France显示文摘 | Ang J B | 2007 | Energy Policy2007，35，10： | 1 |
| 9 | Research, technological change and financial lib- eralization in South Korea显示文摘 | Ang J B | 2010 | Journal of Macroeconomics2010，32，1： | 1 |
| 10 | Economic development, pollutant emissions and energyconsumption in Malaysia显示文摘 | Ang J B | 2008 | Journal of Policy Modeling2008，30，2： | 1 |
| 11 | Seismic shear strength of circular reinforced concrete显示文摘 | Paulay T Ang B G Priestley M J N | 1989 | ACI Structural Journal1989，86，3： | 1 |
| 12 | Isolation and compo-nent analysis of polysaccharide from the Scierotia of Huna显示文摘 | Deng C H Y ang X L Gu X M Wang Y Zhou J Y Xu H B | 2000 | Chin Pharm J2000，35，5： | 1 |
| 13 | CO2 Emissions, Research and Technology Transfer in China显示文摘 | ANG J B | 2009 | Ecological Economics2009，68，10： | 1 |
| 14 | CO2 emissions,energy consumption,and output in France显示文摘 | ANG J B | | 0，，10： | 1 |
| 15 | Photodetachment of Zwitterions : Probing Intramolecular Coulomb Repulsion and Attraction in the Gas Phase Using Pyridinium Dicarboxylate Anions 显示文摘 | WANG X B DACRES J E :ANG X | 2003 | J Am Chem Soc2003，125，1： | 1 |
| 16 | Research, technological change and financial liberalization in South Korea 显示文摘 | Ang J B | 2010 | Journal of Macroeco- nomics2010，32，1： | 1 |
| 17 | Trapping heavy metals by using calcium hydroxyapatite and dielectrophoresis显示文摘 | John B Arun J K Ange N | 2007 | J Hazardous Mater A2007，139，： | 1 |
| 18 | Optimization of the chemi- cal mechanical polishing process for optical silicon substrates 显示文摘 | Zhong Z W Tian Y B Ang Y J | 2012 | The International Journal of Advanced Manufacturing Technology2012，60，9101112： | 1 |
| 19 | CO2 emissions,research and technology transfer in China显示文摘 | Ang J B | 2009 | Ecological Economics2009，，68： | 1 |
| 20 | Research, Technological Change and Fi-nancial Liberalization in South Korea显示文摘 | ANG J B | 2010 | Journal ofMacroeconomics2010，32，1： | 1 |
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