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| 1 | Diagnosis of gastrointestinal bleeding: A practical guide for clinicians显示文摘Gastrointestinal bleeding is a common problem encountered in the emergency department and in the primary care setting. Acute or overt gastrointestinal bleeding is visible in the form of hematemesis, melena or hematochezia. Chronic or occult gastrointestinal bleeding is notapparent to the patient and usually presents as positive fecal occult blood or iron deficiency anemia. Obscure gastrointestinal bleeding is recurrent bleeding when the source remains unidentified after upper endoscopy and colonoscopic evaluation and is usually from the small intestine. Accurate clinical diagnosis is crucial and guides definitive investigations and interventions. This review summarizes the overall diagnostic approach to gastrointestinal bleeding and provides a practical guide for clinicians. | Bong Sik Matthew Kim Bob T Li Alexander Engel Jaswinder S Samra Stephen Clarke Ian D Norton Angela E Li | 2014 | World Journal of Gastrointestinal Pathophysiology2014，5，4： | 13 |
| 2 | Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease (NAFLD) has become an epidemic largely due to the worldwide increase in obesity. While lifestyle modifications and pharmacotherapies have been used to alleviate NAFLD, successful treatment options are limited. One of the main barriers to finding safe and effective drugs for long-term use in NAFLD is the fast initiation and progression of disease in the available preclinical models. Therefore, we are in need of preclinical models that (1) mimic the human manifestation of NAFLD and (2) have a longer progression time to allow for the design of superior treatments. AIM To characterize a model of prolonged high-fat diet (HFD) feeding for investigation of the long-term progression of NAFLD. METHODS In this study, we utilized prolonged HFD feeding to examine NAFLD features in C57BL/6 male mice. We fed mice with a HFD (60% fat, 20% protein, and 20% carbohydrate) for 80 wk to promote obesity (Old-HFD group, n = 18). A low-fat diet (LFD)(14% fat, 32% protein, and 54% carbohydrate) was administered for the same duration to age-matched mice (Old-LFD group, n = 15). An additional group of mice was maintained on the LFD (Young-LFD, n = 20) for a shorter duration (6 wk) to distinguish between age-dependent and age-independent effects. Liver, colon, adipose tissue, and feces were collected for histological and molecular assessments.RESULTS Prolonged HFD feeding led to obesity and insulin resistance. Histological analysis in the liver of HFD mice demonstrated steatosis, cell injury, portal and lobular inflammation and fibrosis. In addition, molecular analysis for markers of endoplasmic reticulum stress established that the liver tissue of HFD mice have increased phosphorylated Jnk and CHOP. Lastly, we evaluated the gut microbial composition of Old-LFD and Old-HFD. We observed that prolonged HFD feeding in mice increased the relative abundance of the Firmicutes phylum. At the genus level, we observed a significant increase in the abundance of Adercreutzia, Coprococcus, Dorea, and Ruminococcus and decreased relative abundance of Turicibacter and Anaeroplasma in HFD mice. CONCLUSION Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. | Kandy T Velázquez Reilly T Enos Jackie E Bader Alexander T Sougiannis Meredith S Carson Ioulia Chatzistamou James A Carson Prakash S Nagarkatti Mitzi Nagarkatti E Angela Murphy | 2019 | World Journal of Hepatology2019，11，8： | 6 |
| 3 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 4 | Rearing veal calves with respect to animal welfare:effects of group housing and solid feed supplementation on growth performance and meat quality显示文摘 | Xiccato G Angela T Queaque P I | | 0，，75： | 1 |
| 5 | Comparison of bioengineered human bone construct from four sources of osteogenic cells 显示文摘 | Angela MHN Aminuddin BS Kok - Keong T | 2005 | J Orthop Sci2005，10，： | 1 |
| 6 | A Full Scale Structural Pavement Structural Study for Mechanistic-Empirical Pavement Design 显示文摘 | Angela L P David H T | 2005 | Journal of the Association of Asphalt Paving Technologistcs2005，74，： | 1 |
| 7 | Diabetes education显示文摘 | ANGELA T DEARINGER RICHARD C | 2013 | American Journal of Preventive Medicine2013，45，6： | 1 |
| 8 | Hydrogen storage in graphite nanofibers:Effect of synthesis catalyst and pretreatment conditions显示文摘 | Angela D Ralph T Nelly M | 2004 | Langmuir2004，20，3： | 1 |
| 9 | Ellagic compounds from Diplopanax stachyanthus 显示文摘 | Duc D K Sung T V Angela M C | 1990 | Phytochemistry1990，29，1： | 1 |
| 10 | Comparison of non-invasive NIR and Raman spectrometries for determination of alcohol content of spirits 显示文摘 | Alison Nordon Angela Mills Ross T | 2005 | Analytica Chimica Acta2005，，： | 1 |
| 11 | Anthocyanin extraction from Jabuticaba (Myrciariacauliflora)skins by different techniques:economic evaluation显示文摘 | Priscilla C Veggi Diego T Santos M Angela | | 0，，01： | 1 |
| 12 | Microparticles am vectors of paradoxical information irt vascular cells including the endothelium: role in health and diseases显示文摘 | Ferhat M Angela T Ramaroson A | 2008 | Pharmacological Reports2008，60，1： | 1 |
| 13 | Minimal requirements for antiphospholipid antibodies ELISA proposed by the European Forum on antiphospholipid antibodies显示文摘 | Angela T Flavio A Genesio B | 2004 | Thrombosis Research2004，114，： | 1 |
| 14 | An assessment of the use of interphase FISH with chromosome special probes as an alterative to cytogenetics in prenatal diagnosis显示文摘 | ANGELA T A TSHERIFA A F PHILLIPA M K | 2000 | Prenat Diagn2000，20，： | 1 |
| 15 | Ellagic compounds from Diplopanax stachyanthus 显示文摘 | Duc D K Sung T V Angela M C | 1990 | Phytochemistry1990，29，1： | 1 |
| 16 | Expertise differences in attentional strategies related to pilot decision makin显示文摘 | ANGELA T SCHRIVER DANIEL G MORROW CHRISTOPHER D WICHENS | 2008 | Human Factors2008，50，6： | 1 |
| 17 | Reproductive factorsand serum uric acid levels in females from the generalpopulation: the KORA F4 study 显示文摘 | Doris S Angela D Barbara T | 2012 | Plos One2012，7，3： | 1 |
| 18 | Iron overload in Africans and African-Americans and a common mutation in the SCL40A1 (ferroportin 1) gene☆显示文摘 | Victor R Gordeuk Angela Caleffi Elena Corradini Francesca Ferrara Russell A Jones Oswaldo Castro Onyinye Onyekwere Rick Kittles Elisa Pignatti Giuliana Montosi Cinzia Garuti Innocent T Gangaidzo Z.A.R Gomo Victor M Moyo Tracey A Rouault Patrick MacPhail A | 2003 | Blood Cells Molecules and Diseases2003，，3： | 1 |
| 19 | Removal of pharmaceuticals in secondary wastewater treatment processes in Taiwan显示文摘 | Angela Y L Yu T Shaik K L | 2009 | J Hazard Mater2009，108，1： | 1 |
| 20 | Detection of Mycobacterium tuberculosis complex in milk using polymerase chain reaction (PCR) 显示文摘 | Angela D P Ciccarese G Forte V T | 2006 | Food Control2006，17，： | 1 |
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