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| 1 | Tenofovir vs lamivudine plus adefovir in chronic hepatitis B:TENOSIMP-B study显示文摘AIM To demonstrate the non-inferiority(15% non-inferiority limit) of monotherapy with tenofovir disoproxil fumarate(TDF) vs the combination of lamivudine(LAM) plus adefovir dipivoxil(ADV) in the maintenance of virologic response in patients with chronic hepatitis B(CHB) and prior failure with LAM.METHODS This study was a Phase IV prospective, randomized, open, controlled study with 2 parallel groups(TDF and LAM+ADV) of adult patients with hepatitis B e antigen(HBe Ag)-negative CHB, prior failure with LAM, on treatment with LAM+ADV for at least 6 mo, without prior resistance to ADV and with an undetectable viral load at the start of the study, in 14 Spanish hospitals. The follow-up time for each patient was 48 wk after randomization, with quarterly visits in which the viral load, biochemical and serological parameters, adverse effects, adherence to treatment and consumption of hospital resources were analysed.RESULTS Forty-six patients were evaluated [median age: 55.4 years(30.2-75.2); 84.8% male], including 22 patients with TDF and 24 with LAM+ADV. During study development, hepatitis B virus DNA(HBV-DNA) remained undetectable, all patients remained HBe Ag negative, and hepatitis B surface antigen(HBs Ag) positive. Alanine aminotransferase(ALT) values at the end of the study were similar in the 2 groups(25.1± 7.65, TDF vs 24.22 ± 8.38, LAM+ADV, P = 0.646). No significant changes were observed in creatinine or serum phosphorus values in either group. No significant differences between the 2 groups were noted in the identification of adverse effects(AEs)(53.8%, TDF vs 37.5%, LAM+ADV, P = 0.170), and none of the AEs which occurred were serious. Treatment adherence was 95.5% and 83.3% in the TDF and the LAM+ADV groups, respectively(P = 0.488). The costs associated with hospital resource consumption were significantly lower with the TDF treatment than the LAM+ADV treatment(€4943 ± 1059 vs €5811 ± 1538, respectively, P < 0.001).CONCLUSION TDF monotherapy proved to be safe and not inferior to the LAM+ADV combination therapy in maintaining virologic response in patients with CHB and previous LAM failure. In addition, the use of TDF generated a significant savings in hospital costs. | Manuel Rodríguez Juan Manuel Pascasio Enrique Fraga Javier Fuentes Martín Prieto Gloria Sánchez-Antolín Jose Luis Calleja Esther Molina María Luisa García-Buey María Angeles Blanco Javier Salmerón María Lucía Bonet Jose Antonio Pons Jose Manuel González Miguel Angel Casado Francisco Jorquera 无 | 2017 | World Journal of Gastroenterology2017，23，41： | 16 |
| 2 | Flocculation, Retention and Drainage in Papermaking: A Comparative Study of Polymeric Additives显示文摘 | Myriam Cadotte Marie-Eve Tellier Angeles Blanco | 2007 | The Canadian Journal of Chemical Enginerring2007，85，： | 1 |
| 3 | Clip closure of a duodenal perforation secondary to a biliary stent显示文摘 | Leopoldo López Rosés Abel Gonzalez Ramirez Angel Lancho Seco Eva Santos Blanco Dolores Iba?ez Alonso Susana Avila Bego?a Urraca Lopez | 2000 | Gastrointestinal Endoscopy2000，，4： | 1 |
| 4 | Novel Methylation Panel for the Early Detection of Colorectal Tumors in Stool DNA显示文摘 | Daniel Azuara Francisco Rodriguez-Moranta Javier de Oca Antonio Soriano-Izquierdo Josefina Mora Jordi Guardiola Sebastiano Biondo Ignacio Blanco Miguel Angel Peinado Victor Moreno Manel Esteller Gabriel Capellá | 2010 | Clinical Colorectal Cancer2010，，3： | 1 |
| 5 | Cloning of repetitive DNA sequences from Toxoplasma gondii and their usefulness for parasite detection显示文摘 | Blanco J C Angel S O Macro E | 1992 | Am J Trop Med Hgy1992，46，3： | 1 |
| 6 | Adenocarcinoma of the female urethra:report of two cases and bibliography review显示文摘 | Feltes Ochoa JA Blanco Carballo O Sánchez Angel T | 2005 | Arch Esp Urol2005，58，7： | 1 |
| 7 | Cloning of repetitive DNA sequences from Toxoplasma gondii and theirusefulness for parasite detection 显示文摘 | BLANCO J ANGEL S MAERO E | 1992 | Am J Trop Med Hyg1992，46，3： | 1 |
| 8 | Cloning of repetitive DNA sequences from Toxoplasma gondii and their usefulness for parasite detection显示文摘 | Blanco JC Angel SO Maero E et a1 | | 0，，03： | 1 |
| 9 | Cloning of repetitive DNA sequences from Toxoplasma gondii and their usefulness for parasite detection显示文摘 | Angel SO Blanco JC Maero E et a1 | | 0，，03： | 1 |
| 10 | Cloning of repetitive DNA sequences from Toxoplasma gondii and their usefulness for parasite detection显示文摘 | Blanco J Angel S Maero E | 1992 | Am J Trop Med Hyg1992，46，3： | 1 |
| 11 | Clangin8 of repetitive DNA sequences from Toxoplasma gond ii and their usefulness f or parasite detection 显示文摘 | Blanco JC Angel SO Maero E | 1992 | Am J T rop Med H yg1992，46，3： | 1 |
| 12 | Clonging of repetitive DNA sequences from Toxoplasma gondii and their usefulness for parasite detection显示文摘 | Blanco JC Angel SO Maero E | 1992 | Am J Trop Med Hyg1992，46，3： | 1 |
| 13 | Early diagnosis of Toxoplasma encephalitis in AIDS patients by dot blot hybridization analysis显示文摘 | Angel SO Maero E Blanco JC | 1992 | J Clin Microbiol1992，30，12： | 1 |
| 14 | Development of a methodology to predict sticky deposits due to the destabilization of dissolved and colloidal material in papermaking -application to different systems显示文摘 | Conception Monte M Angeles Blanco Carlos Negro | 2004 | Chemical Engineering Journal2004，，105： | 1 |
| 15 | SJWD14081900000560显示文摘 | Dong Soon Choi Elvin Blanco Yoo‐Shin Kim Angel A. Rodriguez Hong Zhao Tim Hui‐Ming Huang Chun‐Liang Chen Guangxu Jin Melissa D. Landis Lacey A. Burey Wei Qian Sergio M. Granados Bhuvanesh Dave Helen H. Wong Mauro Ferrari Stephen T. C. Wong Jenny C. Chang | 2014 | Stem Cells2014，，9： | 1 |
| 16 | Treatment of Refractory Uveitis with Adalimumab: A Prospective Multicenter Study of 131 Patients显示文摘 | Manuel Díaz-Llopis David Salom Carmen Garcia-de-Vicu?a Miguel Cordero-Coma Gabriela Ortega Norberto Ortego Marta Suarez-de-Figueroa Maria J. Rio-Pardo Carlos Fernandez-Cid Alex Fonollosa Ricardo Blanco Angel M. Garcia-Aparicio Jose M. Benitez-del-Castillo | 2012 | Ophthalmology2012，，8： | 1 |
| 17 | Toxoplasma gondii: a rapid method for the isolation of pure tachyzoites: preliminary characterization of its genome显示文摘 | Garberi JC Blanco JC Angel SO | 1990 | Mem Inst Oswaldo Cruz1990，85，4： | 1 |
| 18 | FTIR study of the sol–gel synthesis of cementitious gels: C–S–H and N–A–S–H显示文摘 | Ines García-Lodeiro A. Fernández-Jiménez M. Teresa Blanco Angel Palomo | 2008 | Journal of Sol - Gel Science and Technology2008，，1： | 1 |
| 19 | Cloning of repetitive DNA sequences from Toxoplasma gondii and their usefulness for parasite detection显示文摘 | Blanco J C Angel S O Macro E | 1992 | Am J Trop Med Hyg1992，46，3： | 1 |
| 20 | Cloning of repetitive DNA sequences from Toxoplasma gondii and their usefulness for parasite detection 显示文摘 | Blanco J Angel S Maero E | 1992 | Am J Trop Med Hyg1992，46，3： | 1 |
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