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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Systematic investigation of monolithic bipolar transistors irradiated with neutrons, heavy ions and electrons for space application 显示文摘 | CONSOLANDI C ANGELO P D FALLICA G | 2006 | Nucl Instr and Meth In Phys Res B2006，252，2： | 1 |
| 3 | Hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis显示文摘Cirrhosis is an emerging major cause of the development of hepatocellular carcinoma(HCC),but in non-alcoholic fatty liver disease(NAFLD),up to 50%of patients with HCC had no clinical or histological evidence of cirrhosis.It is currently challenging to propose general recommendations for screening patients with NAFLD without cirrhosis,and each patient should be evaluated on a caseby-case basis based on the profile of specific risk factors identified.For HCC screening in NAFLD,a valid precision-based screening is needed.Currently,when evaluating this population of patients,the use of non-invasive methods can guide the selection of those who should undergo a screening and surveillance program.Hence,the objective of the present study is to review the epidemiology,the pathophysiology,the histopathological aspects,the current recommendations,and novel perspectives in the surveillance of non-cirrhotic NAFLD-related HCC. | Cristiane Valle Tovo Angelo Zambam de Mattos Gabriela Perdomo Coral Giovana D P Sartori Livia Villela Nogueira Gustavo Tovo Both Cristiane A Villela-Nogueira Angelo A de Mattos | 2023 | World Journal of Gastroenterology2023，29，2： | 1 |
| 4 | The molecular pathogenesis of small cell lung cancer显示文摘 | D' Angelo S P Pietanza M C | 2010 | Zhongguo Fei Ai Za Zhi2010，13，11： | 1 |
| 5 | Quantitative Analysis of XANES Spectra of Disordered Systems Based on Molecular Dynamics显示文摘 | Roscioni O M D' Angelo P Chillemi G | 2005 | J Synchrotron Rad2005，121，： | 1 |
| 6 | Shock wave therapy as a treatment of nonunions, avascular necrosis, and delayed healing of stress fractures 显示文摘 | Furia John P Rompe Jan D Cacchio Angelo Maffulli Nicola | 2010 | Foot Ankle Clin2010，15，4： | 1 |
| 7 | Markers of eosinophilic inflammation and risk prediction in patients with coronary artery disease显示文摘 | Falcone C Minoretti P D'Angelo A | | 0，，04： | 1 |
| 8 | A Panel da- ta approach to evaluate the passenger satisfaction of a public transport service 显示文摘 | ANNA C ANTONELLO D ANGELO P | 2014 | Procedia Economics and Finance2014，17，： | 1 |
| 9 | Management of trauma-induced coagulopathy: trends and practices 显示文摘 | D'Angelo M R Dutton R P | 2010 | AANA J2010，78，1： | 1 |
| 10 | Reversible posterior leukoencephalopathy syndrome : report of 2 simultaneous cases in children显示文摘 | D' Angelo P Farruggia P Lo Bello A | 2006 | J Pediatr Hematol Oncol2006，28，3： | 1 |
| 11 | Bilateral adrenal cortical adenomas in primary hyperaldosteronism 显示文摘 | Engel J D Angelos P Rege R V | 1998 | Urology1998，52，4： | 1 |
| 12 | Cl continuities detection intriangular meshes 显示文摘 | Angelo L D Stefano P D | 2010 | Computer-Aided Design2010，42，9： | 1 |
| 13 | Angiotensinconverting enzyme gene deletion polymorphism determines an increase in frequency of migraine attacks in patients sufferingfrom migraine without aura显示文摘 | Paterna S Di Pasquale P D' Angelo A | 2000 | Eur Neurol2000，43，3： | 1 |
| 14 | High thermoelectric figure of merit and nanostructuring in bulk p-type Na1-x PbmSbyTem+2 显示文摘 | Poudeu P F P D Angelo J Downey A D | 2006 | Angewandte Chemic International Edition2006，118，23： | 1 |
| 15 | Protein C and coagulation in sepsis 显示文摘 | D'ANGELO A DELLA VALLE P GIUDICI D | 2004 | Minerva Anestesiol2004，70，5： | 1 |
| 16 | Surface tension,heat capacity,and volume of amphiphilic compounds in formamide solutions显示文摘 | Inglese A Angelo P D Lisi R De | 1998 | Journal of Solution Chemistry1998，27，5： | 1 |
| 17 | Salivary chro- mogranin A, but not a-amylase, correlates with cardiovascular param- eters during high-intensity exercise 显示文摘 | Gallina S Di Manre M D'Amico MA D'Angelo E Sablone A Di Fonso A Bascelli A Izzicupo P Di Baldassarre A | 2011 | Clin Endocrinol ( Oxf)2011，75，： | 1 |
| 18 | Reversible posterior leukoencephalopathy syndrome: report of 2 simultaneous cases in children 显示文摘 | D'Angelo P Farruggia P Lo Bello A | 2006 | J Pediatr H ematol Oncol2006，28，3： | 1 |
| 19 | Altered microRNA expression profile in human pituitary GH adenomas:down-regulation of miRNA targeting HMGA1,HMGA2,and E2F1显示文摘 | D' Angelo D Palmieri D Mussnich P | 2012 | J Clin Endocrinol Metab2012，97，7： | 1 |
| 20 | The protein C pathway and sepsis显示文摘 | Della Valle P Pavani G D'Angelo A | 2012 | Thromb Res2012，129，3： | 1 |
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