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| 1 | 高强度聚焦超声治疗不能手术胰腺癌的1年生存分析:中国和保加利亚的多中心临床研究显示文摘目的:通过多中心临床研究分析高强度聚焦超声治疗不能手术胰腺癌的1年生存情况。方法:2013年1月到2014年1月,中国和保加利亚的不能手术的胰腺癌患者32例,男/女=20/12,年龄41~81(59.8±9.1)岁。胰腺癌病灶最大径20~60(39.3±9.6)mm,远处转移/无转移的患者18/14例。接受HIFU和/或化疗。记录术后并发症,疼痛变化和生存情况。使用Kaplan-Meier法计算总生存率和中位生存时间,比较化疗与否、是否发生远处转移的患者生存率有无差异(Log-Rank检验)。结果:术后1月,皮肤浅Ⅱ°烧伤者2例,经保守处理后1~2周愈合。伴有胰腺癌相关性疼痛症状的患者30例与术前比较,减轻的24例(80.0%),不变的5例(16.7%),加重的1例(3.3%)。所有患者的1年生存率为38.4%,中位生存时间为12个月。接受辅助化疗的患者1年生存率为57.4%,中位生存时间12月;未接受辅助化疗的患者1年生存率为20.8%,中位生存时间为6月;二者间比较有显著性差异。伴有远处转移的患者1年生存率为0%,中位生存时间为7月;无远处转移的患者1年生存率为49.2%,中位生存时间为12月;二者间比较无统计学差异。结论:中国和保加利亚的不能手术胰腺癌患者均能安全完成HIFU治疗,1年生存率和中位生存时间优于其它非手术治疗手段。辅助化疗能增加生存受益,远处转移是预后不良因素。 | 周崑 Dobromir Dimitrov Dimitrov Tihomir Vencislavov Andreev 汪亮 Hyuliya Erdzhanova Feradova Grigor Angelov Gorchev 朱辉 王智彪 | 2015 | 重庆医科大学学报2015，40，3： | 11 |
| 2 | Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer显示文摘 | Marko NF Suh JH Chao ST Barnett GH Vogelbaum MA Toms S Well R J Angelov L | 2011 | 中国神经肿瘤杂志2011，9，1： | 4 |
| 3 | Stereotactic radiosurgery as single-modality treatment of incidentally identified renal cell carcinoma brain metastases显示文摘 | Marko NF Angelov L Toms SA Suh JH Chao ST Vogelbaum MA Barnett GH Weil RJ | 2010 | 中国神经肿瘤杂志2010，8，3： | 4 |
| 4 | Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair显示文摘Among the macromolecular drug targets in neurodegenerative disorders, the neurotrophin brain-derived neurotrophic factor(BDNF) and its high-affinity tropomyosin-related kinase receptor(Trk B) present strong interest for nanomedicine development aiming at neuronal and synaptic repair. Currently, BDNF is regarded as the neurotrophic factor of highest therapeutic significance. However, BDNF has delivery problems as a protein drug. The enhanced activation of the transcription factor CREB(c AMP response element-binding protein) has been evidenced to increase the BDNF gene expression and hence the production of endogenous BDNF. We assume that BDNF delivery by nanocarriers and mitochondrial protection may provide high potential for therapeutic amelioration of the neuroregenerative strategies. Beneficial therapeutic outcomes may be expected for synergistic dual or multi-drug action aiming at(i) neurotrophic protein regulation in the central and peripheral nervous systems, and(ii) diminishment of the production of reactive oxygen species(ROS) and the oxidative damage in mitochondria. Our research strategy is based on a nanoarchitectonics approach for the design of nanomedicine assemblies by hierarchical self-assembly. We explore nanoarchitectonics concepts in soft-matter nanotechnology towards preparation of biodegradable self-assembled lipid nanostructures for safe neuro-therapeutic applications of multi-target nanomedicines. | Angelina Angelova Borislav Angelov | 2017 | Neural Regeneration Research2017，12，6： | 3 |
| 5 | Sol-gel synthesis, surface and magnetic properties of nanocrystalline SmAlO_3显示文摘Nanocrystals of single-phase samarium monoaluminate (SmAlO3) were synthesized and studied for the first time. Malic acid was employed as a new complexing agent in the sol-gel process. The material was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDS), specific surface area and density. The lowest size of the nanoparticles was about 50–60 nm and some of them formed agglomerates. The binding energies of core-level electrons of Sm (3d, 4d, 4f, 5p, 5s), Al (2s, 2p) and O (1s, 2s) in nanocrystalline SmAlO3 were obtained by X-ray photoelectron spectroscopy (XPS) and found shifted in respect to the correspond- ing values for the same elements. The temperature dependence of the AC magnetic susceptibility of the substance was determined between 2.5 and 250 K. The experimental molar magnetic susceptibility was compared with the theoretical one of Sm3+ ions. The nanomaterial was found paramagnetic in the specified temperature range with Curie-type paramagnetism below 12 K. | Dimitar Petrov Bogdan Angelov Vasil Lovchinov | 2010 | Journal of Rare Earths2010，28，4： | 3 |
| 6 | Poly-Si thin films on glass substrates显示文摘 | Malinovska D D Angelov O Sendova M | 2004 | Thin Solid Films2004，，： | 1 |
| 7 | Lactic acid bacteria and yeasts in kefir grains and kefir made from them显示文摘 | Simova E Beshkova D Angelov A | 2002 | Journal of In- dustrial Microbiology and Biotechnology2002，28，1： | 1 |
| 8 | A genetic- algorithm- based approach to optimization of bioprocesses described by fuzzy rules显示文摘 | P ANGELOV R GUTHKE | 1997 | Bioproeess Engineering1997，，16： | 1 |
| 9 | Lactic acid bacteria and yeasts in Kefir grains and Kefir made from them显示文摘 | SIMOVA E BESHKOVA D ANGELOV A | 2002 | J Microbioi Biotech2002，28，1： | 1 |
| 10 | Comparing the CNS morpholog and immunobiology of different EAE models in C57BL/6 miee-a step towards understanding the complexity of multiple sclero- sis显示文摘 | Kuerten S Angelov DN | 2008 | AnnAnat2008，190，1： | 1 |
| 11 | An approach to online identification of Takagi-Sugeno fuzzy models显示文摘 | Angelov P P Filev D P | 2004 | IEEE Trans on Systems Man and Cybernetics2004，34，1： | 1 |
| 12 | Tolerances of Several Marine Species to Co-60 Irradiation显示文摘 | White J C Angelovic J W | | 0，，： | 1 |
| 13 | Olfactory ensheathing glia and schwann cells: two of a kind 显示文摘 | Wewetzer K Verdu E Angelov DN | 2002 | Cell Tissue Res2002，309，： | 1 |
| 14 | Nimodipine accelerates axonal sprouting after surgical repair of rat facial nerve显示文摘 | Angelov DN Neiss WF Streppel M | 1996 | J Neurosci1996，16，3： | 1 |
| 15 | Copper(Ⅱ) and cobalt(Ⅱ) dicarboxylate-based layered magnets:influence of π electron ligands on the long range magnetic ordering显示文摘 | Rabu P Rueff J M Huang Z L Angelov S Souletie J Drillon M | | 0，，11： | 1 |
| 16 | Development of anew oat-based probiotic drink 显示文摘 | Angelov A Gotcheva V Kuncheva R | 2006 | Int J Food Microbiol2006，112，1： | 1 |
| 17 | Optimization in an intuitionistic fuzzy environment显示文摘 | Plamen P Angelov | 1997 | Fuzzy Sets and Systems1997，86，： | 1 |
| 18 | Genomic analysis reveals Lactobacillus sanfranciscensis as stable element in traditional sourdoughs 显示文摘 | Vogel RF Pavlovic M Ehrmann MA Wiezer A Liesegang H Offschanka S Voget S Angelov A Bocker G Liebl W | 2011 | Microb Cell Fact2011，10，1： | 1 |
| 19 | Lack of efficacy of etanercept in sjogren syndrome correlates with failed suppression of tumour necrosis factor alpha and systemic immune activation显示文摘 | Moutsopoulos NM Katsifis GE Angelov N | 2008 | Ann Rheum Dis2008，67，10： | 1 |
| 20 | Determination of the two-dimensional distribution of potentials in integrated circuits by the laser scanning method 显示文摘 | Kravchenko L N Sagiyan G M | 1988 | Sov J Quantum Electron1988，18，8： | 1 |
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