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| 1 | Alleviated mucosal and neuronal damage in a rat model of Crohn's disease显示文摘AIM:To establish a rat model suitable to investigate the repetitive relapsing inflammations(RRI)characteristic to Crohn’s disease.METHODS:Colitis was induced by 2,4,6-trinitrobenzenesulfonic acid(TNBS).RRI were mimicked by repeating administrations of TNBS.Tissue samples were taken from control,once,twice and three times treated rats from the inflamed and adjacent non-inflamed colonic segments at different timepoints during the acute intestinal inflammation.The means of the ulcerated area were measured to evaluate the macroscopic mu-cosal damage.The density of myenteric neurons was determined on whole mounts by Hu C/Hu D immunohistochemistry.Heme oxygenase-1(HO-1)expression was evaluated by molecular biological techniques.RESULTS:TNBS-treated rats displayed severe colitis,but the mortality was negligible,and an increase of body weight was characteristic throughout the experimental period.The widespread loss of myenteric neurons,and marked but transient HO-1 up-regulation were demonstrated after the first TNBS administration.After repeated doses the length of the recovery time and extent of the ulcerous colonic segments were markedly decreased,and the neuronal loss was on a smaller scale and was limited to the inflamed area.HO-1 m RNA level was notably greater than after a single dose and overexpression was sustained throughout the timepoints examined.Nevertheless,the HO-1protein up-regulation after the second TNBS treatment proved to be transient.Following the third treatment HO-1 protein expression could not be detected.CONCLUSION:Experimentally provoked RRI may exert a protective preconditioning effect against the mucosal and neuronal damage.The persistent up-regulation of HO-1 m RNA expression may correlate with this. | Petra Talapka Lajos István Nagy Alexandra Pál Marietta Zita Poles Anikó Berkó Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2014 | World Journal of Gastroenterology2014，20，44： | 3 |
| 2 | Structural and molecular features of intestinal strictures in rats with Crohn's-like disease显示文摘AIM: To develop a new rat model we wanted to gain a better understanding of stricture formation in Crohn's disease(CD).METHODS: Chronic colitis was induced locally by the administration of 2,4,6-trinitrobenzenesulfonic acid(TNBS). The relapsing inflammation characteristic to CD was mimicked by repeated TNBS treatments. Animals were randomly divided into control, once, twice and three times TNBS-treated groups. Control animals received an enema of saline. Tissue samples were taken from the strictured colonic segments and also adjacent proximally and distally to its 60, 90 or 120 d after the last TNBS or saline administrations. The frequency and macroscopic extent of the strictures were measured on digital photographs. The structural features of strictured gut wall were studied by light- and electron microscopy. Inflammation related alterations in TGF-beta 2 and 3, matrix metalloproteinases 9(MMP9) and TIMP1 m RNA and protein expression were determined by quantitative real-time PCR and western blot analysis. The quantitative distribution of caspase 9 was determined by post-embedding immunohistochemistry.RESULTS: Intestinal strictures first appeared 60 d after TNBS treatments and the frequency of them increased up to day 120. From day 90 an intact lamina epithelialis, reversible thickening of lamina muscularis mucosae and irreversible thickening of the muscularis externa were demonstrated in the strictured colonic segments. Nevertheless the morphological signs of apoptosis were frequently seen and excess extracellular matrix deposition was recorded between smooth muscle cells(SMCs). Enhanced caspase 9 expression on day 90 in the SMCs and on day 120 also in myenteric neurons indicated the induction of apoptosis. The m RNA expression profile of TGF-betas after repeated TNBS doses was characteristic to CD, TGF-beta 2, but not TGF-beta 3 was up-regulated. Overexpression of MMP9 and down-regulation of TIMP1 were demonstrated. The progressive increase in the amount of MMP9 protein in the strictures was also obvious between days 90 and 120 but TIMP1 protein was practically undetectable at this time.CONCLUSION: These findings indicate that aligned structural and molecular changes in the gut wall rather than neuronal cell death play the primary role in stricture formation. | Petra Talapka Anikó Berkó Lajos István Nagy Lalitha Chandrakumar Mária Bagyánszki László Géza Puskás éva Fekete Nikolett Bódi | 2016 | World Journal of Gastroenterology2016，22，22： | 3 |
| 3 | Electrochemical hydrogen storage performance of Mg-Ti-Zr-Ni alloys显示文摘 | ANIK M AKAY I O'ZDEMIR G | 2009 | International Journal of Hydrogen Energy2009，34，24： | 1 |
| 4 | MFL spectroscopy findings in tuberculous spondylitis,compa, rison with Medic type-I end-plate chsnges snd metastatic vertebral disesse显示文摘 | Anik Y Oift i E Sa risoy HT Aka nsel G et a I | 2009 | European Journsl of R sdiology2009，71，2： | 1 |
| 5 | Analysis of the electrochemical reaction behavior of alloy AZ91 by EIS technique in H3 PO4/KOH buffered K2 SO4 solutions 显示文摘 | Anik M Celikten G | 2007 | Corro-sion Science2007，49，： | 1 |
| 6 | Analysis of the electrochemical reaction behavior of alloy AZ91 by EIS technique in H3PO4/KOH buffered K2SO4 solutions显示文摘 | Anik M Celikten G | 2007 | Corros Sci2007，49，： | 1 |
| 7 | Significance of serum neurokinin B and kisspeptin levels in the differential diagnosis of premature thelarche and idiopathic central precocious puberty 显示文摘 | ABACI A ATLI G ANIK A | 2015 | Peptides2015，64，： | 1 |
| 8 | Vitamin D receptor gene polymorphisms in a group of postmenopausal Turkish women: association with bone mineral density 显示文摘 | Yoldemir T Yavuz OG Anik G | 2011 | Climacteric2011，14，3： | 1 |
| 9 | Extracellular matrix of cartilage and meniscus by ESEM and immunogold labeling显示文摘 | Monica N Anik C Anne G | 2009 | Microsc Microanal2009，15，7： | 1 |
| 10 | Cross-reactivity of adrenal steroids with aldosterone may prevent the accurate diagnosis of congenital adrenal hy- perplasia显示文摘 | Tuhan HU Catli G Anik A | 2015 | J Pediatr Endocrinol Metab2015，28，56： | 1 |
| 11 | Electrochemical hydrogen storage performance of Mg-Ti-Zr-Ni alloys显示文摘 | Anik M Akay I O′zdemir G | 2009 | International Journal of Hydrogen Energy2009，34，24： | 1 |
| 12 | Increased nitric oxide levels as an early sign of premature aging in diabetes显示文摘 | Krisztián Stadler Veronika Jenei Gábor von B?lcsházy Anikó Somogyi Judit Jakus | 2003 | Free Radical Biology and Medicine2003，，10： | 1 |
| 13 | Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection显示文摘 | Rainer Schulz Philipp Maximilian G?rge Anikó G?rbe Péter Ferdinandy Paul D. Lampe Luc Leybaert | 2015 | Pharmacology and Therapeutics2015，，： | 1 |
| 14 | HER2-testing in 538 consecutive breast cancer cases using FISH and immunohistochemistry显示文摘 | Anikó Kovács G?ran Stenman | 2009 | Pathology - Research and Practice2009，，1： | 1 |
| 15 | Epidemiology, classifica- tion and management of undescended testes : does medication have value in its treatment? 显示文摘 | Abaci A Catli G Anik A | 2013 | J Clin Res Pediatr Endo- crinol2013，5，2： | 1 |
| 16 | Endemic carbapenem-resistant A cinetobacter species in Brooklyn, New York:citywide prevalence,interinstitutional spread, and relation to antibiotic usage 显示文摘 | M anikal V M L andman D Saurina G | 2000 | Clin Infect Dis2000，31，： | 1 |
| 17 | The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children显示文摘 | Abaci A Catli G Anik A | 2013 | Pediatr Diabetes2013，14，3： | 1 |
| 18 | Diffusion-weighted imaging in the differential diagnosis of simple and hydatid cysts of the liver显示文摘 | Arslan A Akanl G Anik Y | | 0，，01： | 1 |
| 19 | The relation of leptin and soluble leptiu receptor levels with metabolic and clinical parameters in obese and healthy children 显示文摘 | Catli G Anik A Tuhan H U | 2014 | Peptides2014，56，： | 1 |
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