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| 1 | Role of angiotensin converting enzyme and angiotensinogen gene polymorphisms in angiotensin converting enzyme inhibitor-mediated antiproteinuric action in type 2 diabetic nephropathy patients显示文摘AIM To investigate the role of genetic variants of angiotensin converting enzyme(ACE) and angiotensinogen(AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy(DN) patients.METHODS In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor(ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio(ACR) in urine. Genotyping of ACE I/D and AGT M235 T polymorphisms were performed by using primer specific polymerase chain reaction(PCR) and PCR-RFLP techniques, respectively. RESULTS Forty-eight percent of DN patients(responders) benefited with respect to proteinuria from ACE inhibitor therapy at 6 mo follow-up. A significant reduction in ACR was observed after 6 mo treatment with ACE inhibitor irrespective of whether DN patients were micro-albuminuric(≥ 30 and < 300 mg/g creatinine) or macro-albuminuric(≥ 300 mg/g creatinine) at the time of enrollment. However, macro-albuminuric patients(55%) showed better response to therapy. A reduction in urinary ACR was found independent of genotypes of ACE I/D and AGT M235 T polymorphisms although macro-albuminuric patients having TT genotype showed statistically insignificant increased response(72%). CONCLUSION ACE inhibitor therapy reduced urinary ACR by ≥ 30% in 50% of DN patients and the response is independent of ACE I/D and AGT M235 T polymorphisms. | Neerja Aggarwal Pawan Kumar Kare Parul Varshney Om Prakash Kalra Sri Venkata Madhu Basu Dev Banerjee Anil Yadav Alpana Raizada Ashok Kumar Tripathi | 2017 | World Journal of Diabetes2017，8，3： | 4 |
| 2 | Cluster- based multiple task allocation in distributed computing system 显示文摘 | Deo Prakash Vidyarthi Anil Kumar Tripathi | 2004 | Parallel and distributed processing symposium2004，，： | 1 |
| 3 | Evaluation of CERES - Wheat and CropSyst models for water-nitrogen interactions in wheat crop 显示文摘 | Anil Kumar Singh Rojalin Tripathy Usha Kiran Chopra | 2008 | Agricultural Water Management2008，95，7： | 1 |
| 4 | Rebrand- ing and Organisational Pe~Cormance-Some Issues of Relevance 显示文摘 | Anil Kumar Singh Vikas Tripathi Priyender Yadav | 2012 | American Journal of Soclolo gical Research2012，2，5： | 1 |
| 5 | Exploration of soil bacterial communities for their potential as bioresouce显示文摘 | Suresh Kumar Dubey Anil Kumar Tripathi Siddh Nath U- padhyay | 2006 | Bioresource Technology2006，97，： | 1 |
| 6 | Evaluationof CERES-wheat and cropSyst models for water-nitrogen interactionsin wheat crop显示文摘 | Anil Kumar Singh Rojalin Tripathy Usha Kiran Chopra | 2008 | Agricultural water management2008，95，： | 1 |
| 7 | Phenomenology,disability and sexual functioning in female Dhat syndrome:a study of tertiary care gynaecology outpatients显示文摘Background Dhat syndrome,a clinical condition related to semen loss in urine often found among males in India,has rarely been described as a separate clinical condition in females.Women with the syndrome complain of passing vaginal discharge and can be excessively concerned and preoccupied with it,often attributing various physical symptoms to the loss of vaginal fluids.Aims This study aimed to assess the sociodemographic and clinical profiles of female patients with Dhat syndrome and their perceived stress,disability and sexual functioning.Methods Sociodemographic details of 70 females with non-pathological vaginal discharge were evaluated with a semistructured sociodemographic assessment.The phenomenology of the vaginal discharge was assessed with the Scale for Assessment of Female Dhat Syndrome Questionnaire.Anxiety and depressive symptoms were measured with the Hospital Anxiety and Depression Scale.Perceived stress in the past month and disability caused by the illness were assessed with the Perceived Stress Scale and the World Health Organization Disability Assessment Scale.In addition,the Diagnostic and Statistical Manual of Mental Disorders,Fifth Edition,Level 2 Somatic Symptoms Scale was administered to rate the severity of somatic symptoms,and sexual functioning was evaluated using the Female Sexual Function Index(FSFI)scale for women who had had sexual intercourse in the past month.Results The mean age of onset vaginal discharge was 23.0(6.6)years.Biological factors,such as urinary tract infection,were the commonly attributed cause of the loss of vaginal fluids.Psychiatric comorbidity and perceived moderate stress in the past month were found in 38.6%and 68.6%of female patients with Dhat syndrome,respectively.Disability scores tended to be low.Among the females having had sexual intercourse in the past month,48.3%had FSFI scores indicative of a female sexual disorder.Conclusions The clinical presentation of women with non-pathological vaginal discharge is similar to that of males with Dhat syndrome.It requires comprehensive assessment and management that targets the biological,social and psychological factors and cultural issues. | Shubha Joshi Adarsh Tripathi Smriti Agarwal Nisha Singh Bandna Gupta Anil Nischal Sujita Kumar Kar | 2022 | General Psychiatry2022，35，5： | 0 |
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