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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | Antihyperglycemic activity,antihyperlipedemic activity,haematological effects and histopathological analysis of Sapindus mukorossi Gaerten fruits in streptozotocin induced diabetic rats显示文摘Objective:To investigate the antihyperglycemic and antihyperlipidemie properties of hydroalcoholic extract of fruits of Sapindus mukorossi Caerlen and its beneficial effect on haeniatological parameters with histopathological analysis in streptpzotocin induced diabetic rats.Methods:Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and standard drug glybenclamide(0.5 mg/kg body weight) were administered to diabetic rats.Effect of extract on hyperglycemia,hyperlipidemia and hematological parameters was studied in diabetic rats.Histopathological changes in diabetic rat pancreas were also observed after extract and glybenclamide treatment.Results:Daily oral administration of Sapindus mukorossi fruits extract(250 and 500 mg/kg body weight) and glybenclamide for 20 days showed beneficial effects on blood glucose level(P<0.01) and lipid level.The extract has a favorable effect on the histopathological changes of the pancreas in streptozotocin induced diabetes.Conclusions: These findings reveal that the hydroalcoholic extract of Sapindus mukorossi fruits extract possesses antihyperglycemic and antihyperlipidemie properties.In addition.the extract can prevent various complications of diabetes and improve some haeniatological parameters. | Neeraj Verma G Amresh P K Sahu Neelam Mishra Anil P Singh Ch V Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，7： | 14 |
| 3 | Hepatoprotective potential of ethanolic extract of Ziziphus oenoplia(L.)Mill roots against antitubercular drugs induced hepatotoxicity in experimental models显示文摘Objective:To evaluate the hepatoprotective potential of ethanolic(50%) extract of Ziziphus oenoplia(L.) Mill(Z.oenoplia) root against isoniazid(INH) and rifampicin(RIF) induced liver damage in animal models.Methods:Five groups of six rats each were selected for the study.Ethanolic extract at a dose of 150 and 300 mg/kg as well as silymarin(100 mg/kg) were administered orally once daily for 21 d in INH + RIF treated groups.The serum levels of glutamic oxaloacetic transaminase(SGOT),glutamate pyruvate transaminase(SGPT),alkaline phosphatase (SALP),and bilirubin were estimated along with activities of superoxide dismutase,catalase, glutathione S-transferase,glutathione peroxidase,and hepatic melondialdehyde formation. Histopathological analysis was carried out to assess injury to the liver.Result:The considerably elevated serum enzymatic activities of glutamic oxaloacetic transaminase,glutamate pyruvate transaminase,alkaline phosphatase and bilirubin due to INH + RIF treatment were restored towards norma) in a dose dependent manner after the treatment with ethanolic extract of Z.oenoplia roots.Meanwhile,the decreased activities of superoxide dismutase,catalase, glutathione S-transferase and glutathione peroxidase were also restored towards normal dose dependency.In addition,ethanolic extract also significantly prevented the elevation of hepatic melondialdehyde formation in the liver of INH + RIF intoxicated rats in a dose dependent manner. The biochemical observations were supplemented with histopathological examination of rat liver sections.Conclusions:The results of this study slrongly indicate that ethanolic extract of Z.oenoplia has a potent hepatoprotective action against INH + RIF induced hepatic damage in rats. | Ch V Rao AKS Rawat Anil P Singh Arpita Singh Neeraj Verma | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 6 |
| 4 | How to perform gastrointestinal ultrasound: anatomy and normal findings显示文摘Gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUS includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth. | Nathan S S Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg Dagmar Schreiber-Dietrich Christoph F Dietrich | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 5 | Value of the 12-Lead ECG in Wide QRS Tachycardia显示文摘 | John M Mithilesh K Anil V | 2006 | Cardiol Clin2006，，： | 1 |
| 6 | Modeling Reaction Quench Times in the Waste Heat Boiler of a Claus Plant 显示文摘 | Nasato Linda V Karan Kunal Mehrotra Anil K Behie Leo A | 1994 | Ind Eng Chem Res1994，33，： | 1 |
| 7 | Matching of Palmprlnts显示文摘 | Nicolae Duta Anil K J a in Kanti V Mardia | 2002 | Pattern Recognition Letters2002，23，： | 1 |
| 8 | Influence of tin content on tribological characteristics of spray formed AI-Si alloys显示文摘 | Anil M Srivastava V C Ghosh M K | 2010 | Wear2010，268，1112： | 1 |
| 9 | Formation of hydrothermal deposits at Kings Triple Junction, northern Lau back-arc basin SW Pacific: The geochemical perspectives 显示文摘 | Anil L P Durbar R Balaram V | 2001 | Journal of AsianEarth Sciences2001，38，34： | 1 |
| 10 | Thermodynamic Stabilities of SrCeO3 and BaCeO3 Using a Molten Salt Method and Galvanic Cells显示文摘 | Srikanth G Anil V | 1993 | J Electrochem Soc1993，140，4： | 1 |
| 11 | Instability of BaCeO3 in H2O-containing Atmospheres显示文摘 | Cameron W T Anil V V | 1996 | J Electrochem Soc1996，143，4： | 1 |
| 12 | De- velopment and characterization of polyrner-ceramic continuous fiber reinforced functionally graded composites for aerospace ap plication显示文摘 | Kumar Suresh Murthy Reddy K V V S Kumar Anil | 2013 | Aerospace Science and Technology2013，26，1： | 1 |
| 13 | National Mesothelioma Virtual Bank: A standard based biospecimen and clinical data resource to enhance translational research显示文摘 | Waqas A Anil V P Linda S | 2008 | BMC Cancer2008，8，： | 1 |
| 14 | Minimum-variance estimation of re-entry debris trajectories显示文摘 | Anil V R | 1999 | AIAA-99-41661999，，： | 1 |
| 15 | Image retrieval using color and shape显示文摘 | Aditya V | 1996 | Pattern Recognition1996，29，8： | 1 |
| 16 | Management of edema in nephrotic syndrome显示文摘 | Anil V Mukta M Arvind B | 2004 | Indian Pediatr2004，41，： | 1 |
| 17 | Application ofpolymerase chain reaction fingerprinting to differentiateOrnithobacterium rhinotracheale isolates显示文摘 | Anil J T Binu T V Vanessa C L | 2007 | J Vet DiagnInvest2007，19，： | 1 |
| 18 | In - situUV - visible study of Pd nanocluster formation in solut-ionw显示文摘 | ANIL V GAIKWAD GADI ROTHENBERG | 2006 | Physical Chemistry Chemical Physics:2006，8，： | 1 |
| 19 | Prognostic implications of cell cycle,apoptosis,and angiogenesis biomarkers in non-small cell lung cancer显示文摘 | Sunil S Anil V Danielle A | 2005 | Clin Cancer Res2005，11，11： | 1 |
| 20 | Investigation of cracks generated during flow forming of Nb-Hf-Ti alloy sheet 显示文摘 | Gupta R K Ghosh B R Anil Kumar V | 2007 | Journal of Failure Analysis and Prevention2007，，7： | 1 |
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