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| 1 | Hyperthermophilic asparaginase mutants with enhanced substrate affinity and antineoplastic activity:structural insights on their mechanism of action显示文摘 | SAURABH B ANKIT S GOUTAM M | 2012 | Faseb Journal2012，26，3： | 1 |
| 2 | Radiation processing of food proteins-A review on the recent developments显示文摘 | Yau-Hoong Kuan Rajeev B Ankit P | | 0，，30： | 1 |
| 3 | Gastric intestinal metaplasia development in African American predominant United States population显示文摘BACKGROUND Gastric cancer significantly contributes to cancer mortality globally.Gastric intestinal metaplasia(GIM)is a stage in the Correa cascade and a premalignant lesion of gastric cancer.The natural history of GIM formation and progression over time is not fully understood.Currently,there are no clear guidelines on GIM surveillance or management in the United States.AIM To investigate factors associated with GIM development over time in African American-predominant study population.METHODS This is a retrospective longitudinal study in a single tertiary hospital in Washington DC.We retrieved upper esophagogastroduodenoscopies(EGDs)with gastric biopsies from the pathology department database from January 2015 to December 2020.Patients included in the study had undergone two or more EGDswith gastric biopsy.Patients with no GIM at baseline were followed up until they developed GIM or until the last available EGD.Exclusion criteria consisted of patients age<18,pregnancy,previous diagnosis of gastric cancer,and missing data including pathology results or endoscopy reports.The study population was divided into two groups based on GIM status.Univariate and multivariate Cox regression was used to estimate the hazard induced by patient demographics,EGD findings,and Helicobacter pylori(H.pylori)status on the GIM status.RESULTS Of 2375 patients who had at least 1 EGD with gastric biopsy,579 patients were included in the study.138 patients developed GIM during the study follow-up period of 1087 d on average,compared to 857 d in patients without GIM(P=0.247).The average age of GIM group was 64 years compared to 56 years in the non-GIM group(P<0.001).In the GIM group,adding one year to the age increases the risk for GIM formation by 4%(P<0.001).Over time,African Americans,Hispanic,and other ethnicities/races had an increased risk of GIM compared to Caucasians with a hazard ratio(HR)of 2.12(1.16,3.87),2.79(1.09,7.13),and 3.19(1.5,6.76)respectively.No gender difference was observed between the study populations.Gastritis was associated with an increased risk for GIM development with an HR of 1.62(1.07,2.44).On the other hand,H.pylori infection did not increase the risk for GIM.CONCLUSION An increase in age and non-Caucasian race/ethnicity are associated with an increased risk of GIM formation.The effect of H.pylori on GIM is limited in low prevalence areas. | Akram I Ahmad Arielle Lee Claire Caplan Colin Wikholm Ioannis Pothoulakis Zaynab Almothafer NishthaRaval Samantha Marshall Ankit Mishra Nicole Hodgins In Guk Kang Raymond K Chang Zachary Dailey Arvin Daneshmand Anjani Kapadia Jae Hak Oh Brittney Rodriguez Abhinav Sehgal Matthew Sweeney Christopher B Swisher Daniel F Childers Corinne O'Connor Lynette M Sequeira Won Cho | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，10： | 1 |
| 4 | Biosorption of Pb2+ by original and protonated citrus peels:Equilibrium,kinetics,and mechanism显示文摘 | Silke S Ankit B | 2009 | Chemical Engineering Journal2009，146，2： | 1 |
| 5 | 流行的评估和在有稳定的长期的心失败的病人的疼痛的严厉显示文摘 AIM:To evaluate the prevalence and severity of pain in patients with chronic stable heart failure(HF) in an outpatient clinic setting.METHODS:This is a cross-sectional study evaluating symptoms of generalized or specific pain in patients with chronic stable heart failure.A standardized questionnaire(Edmonton Symptom Assessment System) was administered during a routine outpatient clinic visit.The severity of pain and other symptoms were assessed on a 10 point scale with 10 being the worst and 0 representing no symptoms.RESULTS:Sixty-two patients [age 56 ± 13 years,51 males,11 females,mean ejection fraction(EF) 33% ± 17%] completed the assessment.Thirty-two patients(52%) reported any pain of various character and location such as chest,back,abdomen or the extremities,with a mean pain score of 2.5 ± 3.1.Patients with an EF less than 40%(n = 45,73%) reported higher pain scores than patients with an EF greater than 40%(n = 17,27%),scores were 3.1 ± 3.3 vs 1.2 ± 1.9,P < 0.001.Most frequent symptoms were tiredness(in 75% of patients),decreased wellbeing(84%),shortness of breath(SOB,76%),and drowsiness(70%).The most severe symptom was tiredness with a score of 4.0 ± 2.8,followed by decreased wellbeing(3.7 ± 2.7),SOB(3.6 ± 2.8),and drowsiness(2.8 ± 2.8).CONCLUSION:Pain appears to be prevalent and significantly affects quality of life in HF patients.Adequate pain assessment and management should be an integral part of chronic heart failure management. | Dioma U Udeoji Ankit B Shah Parag Bharadwaj Peter Katsiyianis Ernst R Schwarz | 2012 | World Journal of Cardiology2012，4，8： | 1 |
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