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您的检索式：作者名="Anne Imberty"
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| 1 | Structure/function studies of glycosyltransferases显示文摘 | Christelle Breton Anne Imberty | 1999 | Current Opinion in Structural Biology1999，，5： | 2 |
| 2 | A revisit to the three-dimensional structure of B-type starch 显示文摘 | Anne Imberty Serge Perez | 1988 | Biopolymers1988，27，： | 1 |
| 3 | Rim-differentiation vs. mixture of constitutional isomers: A binding study between pillar[5]arene-based glycoclusters and lectins from pathogenic bacteria显示文摘Macrocycle-based glycoclusters, on account of their promising anti-adhesive properties against bacteria,are potential therapeutic alternatives to classic antibiotics through the much less explored anti-adhesive strategy. In this study, a series of constitutionally-pure pentavalent glycoclusters was prepared by conjugating assorted azido-carbohydrates onto a penta-propargyl rim-differentiated pillar[5]arene(RD-P[5])scaffold through Cu(I)-catalyzed azide–alkyne cycloaddition “click” reactions. Their binding towards therapeutically relevant bacterial lectins, such as Lec A and Lec B from Pseudomonas aeruginosa and concanavalin A(Con A), were evaluated subsequently by isothermal titration calorimetric studies. Most of these isomerfree RD-P[5] pentavalent glycoclusters, except the fucosylated ones, display good affinities to lectins.Nonetheless, the dissociation constants observed are similar to those displayed by an analogous pentavalent glycocluster consisting of four P[5] constitutional isomers, in which the RD-P[5] component merely accounts for 7% in the mixture. Our results revealed that high constitutional purity is not essential for achieving effective multivalent interactions between P[5]-based glycoclusters and lectins, presumably as a result of the conformationally labile nature of the P[5] scaffold. This information provides valuable design principles for low-cost and facile syntheses of glycosylated P[5]s for biomedical applications. | Zhiping Liu Fanny Demontrond Anne Imberty Andrew C.-H.Sue Sébastien Vidal Hongxia Zhao | 2023 | Chinese Chemical Letters2023，34，2： | 0 |
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