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| 1 | Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis显示文摘AIM To observe the inhibition of antisenseoligonucleotides (asON) phosphorthioate to thetissue inhibitors metalloproteinase-1 (TIMP-1)gene and protein expression in the liver tissue ofimmunologically induced hepatic fibrosis rats.The possibility of reversing hepatic fibrosisthrough gene therapy was observed.METHODS Human serum albumin (HSA) wasused to attack rats, as hepatic fibrosis model, inwhich asONs were used to block the gene andprotein expressing TIMP-1. According to theanalysis of modulator, structure protein, codingseries of TIMP-1 genome, we designed fourdifferent asONs. These asONs were injected intothe hepatic fibrosis models through coccygealvein. The results was observed by RT-PCR formeasuring TIMP-1 mRNA expression,immunohistochemistry and in situ hybridizationfor collagen Ⅰ, Ⅲ, special staining of collagenfiber, and electron microscopic examination.RESULTS Hepatic fibrosis could last within 363days in our modified model. The expressinglevel of TIMP-1 was high during hepatic fibrosisprocess. It has been proved by theimmunohistochemical and the electronmicroscopic examination that the asONphosphorthioate of TIMP-1 could exactly expressin vivo. The effect of colchicine wasdemonstrated to inhibit the expressing level ofmRNA and the content of collagen Ⅰ, Ⅲ in theliver of experimental hepatic fibrosis rats.However, the electron microscopy research andthe pathologic grading of hepatic fibrosisshowed that there was no significant differencebetween the treatment group and the modelgroup (P>0.05).CONCLUSION The experimental rat model ofhepatic fibrosis is one of the preferable modelsto estimate the curative effect of anti-hepaticfibrosis drugs. The asON phosphorthioate ofTIMP-1 could block the gene and proteinexpression of TIMP-1 in the liver of experimentalhepatic fibrosis rats at the mRNA level. It ispossible to reverse hepatic fibrosis, and it isexpected to study a new drug of anti-hepaticfibrosis on the genetic level. Colchicine has verylimited therapeutic effect on hepatic fibrosis,furthermore, its toxicity and side effects areobvious. | Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book. | 2001 | World Journal of Gastroenterology2001，7，3： | 73 |
| 2 | 青藏高原羌塘中部蓝片岩的地球化学特征及其构造意义显示文摘青藏高原羌塘中部的冈玛日 -桃形错地区蓝片岩被认为是板块构造边界的产物 ,通过对其主量元素、微量元素和稀土元素的地球化学特征的综合研究 ,其原岩属于洋岛型碱性玄武岩。再结合该地区的地质研究 ,表明在该地区存在一个古特提斯洋 。 | 邓希光 丁林 刘小汉 An Yin Paul A KAPP Michael A MURPHY Craig E MANNING | 2002 | 岩石学报2002，18，4： | 58 |
| 3 | Liquid Crystal Motion Picture Projector显示文摘LiquidCrystalMotionPictureProjector①SHIYongji(LuoyangTechnologyColege,Luoyang471003,CHN)Abstract:Aliquidcrystalmovingpicturep... | SHI Yongji(Luoyang Technology College,Luoyang 471003,CHN)Abstract: A liquid crystal moving picture projector and method are described.Light incident on a liquid crystal display-type device is selectively scattered or transmitted by respective portions of liquid crystal display,and a projection mechanism projects an image formed by either such scattered light or such transmitted light.A liquid crystal moving picture projector includes a liquid crystal display for creating characteristics of an image,and projecttion optics for projecting images sequentially created by the display.The display includes a liquid crystal material capable of temporary storing information at respective areas.The temporary storage may be a function of charge storing directly on liquid crystal material.A method of projecting plural images in sequence includes:creating an image or characteristics of an image in a liquid crystal material,storing such image in such liquid crystal material,directing light at such liquid crystal material,projecting such image as a function of light transmitted through or scattered by such liquid crystal material,and creating a further image in such liquid crystal material for subsequent projection. | 1997 | Semiconductor Photonics and Technology1997，3，3： | 35 |
| 4 | Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinoma显示文摘INTRODUCTIONSialyl Lewis-X antigen ,correlated with carcinoma, is a group of carbohydrate antigen containing oligosaccharide expressed of embryonic tisue and glycoproteins on cell surface of embryonic tissue[1].The SLeX antigen located on cell surface is synthesized principally by two enzymes ,al ,3fucosyltransfrease and a2, 3sialyctransferase.In adults ,SLeX antigen is expressed principally on the surfaces of granulocytic cells and some tumor cells . | Xiao Wei Li~1 Yan Qing Ding~1 Jun Jie Cai~1 Shao Qing Yang~2 Lian Bing An~3 Dong Fang Qiao~3 ~1Department of Pathology,Nanfang Hospital of the First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2The Northern Hospital of PLA,Shenyang 110015,Liaoning Province,China ~3Department of Electronmicroscopy,First Military Medical University,Guangzhou 510515,Gangdong Province,ChinaDr.Xiao Wei Li graduated from the First Military Medical University with a MM degree in 1999.Physician in Charge of pathology,having 6 papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 19 |
| 5 | Inflammatory pseudotumor of the liver: 13 cases of MRI findings显示文摘INTRODUCTIONInflammatory pseudotumor of the liver ,a rare benign lesion ,is often confused with the malignant tumors .Until 1998,less than 80 cases had been reported in the world [1,2].The accuracy of the pre-surgical diagnosis was low p[3,4] ,and very few materials on the diagnosis using dynamic MRI were reported [5-7] .We collected thirteen cases of inflammatory pseudotumor of the liver were collected and roved by pathology with MRI studies .Our purpose is to describe and analyze the MRI findings of this lesion and find out the valuable signs suggesting the diagnosis so as to avoid unnecessary operations. | Fu Hua Yan Kang Rong Zhou Ya Ping Jiang Wei Bin Shi Department of Radiology,Zhongshan Hospital,Medical Center of Fudan University (Former Shanghai Medical University),180 Fenglin Road,Shanghai 200032,ChinaDr.Fu Hua Yan graduated from Shanghai Medical University as a postgraduate in 1996,now an associated professor,a radiologist in chief specialized in the diagnosis of CT and MRI in hepatic diseases,having 22 papers published.She is the associated editor of the books Spiral CT and Body MRI. | 2001 | World Journal of Gastroenterology2001，7，3： | 8 |
| 6 | Reaction decoupling in thermochemical fuel conversion and technical progress based on decoupling using fluidized bed显示文摘Thermochemical conversion of fuels via pyrolysis/carbonization,cracking,gasification and combustion has to involve a number of individual reactions called attribution reactions to form an intercorrelated reaction network for any conversion process.By separating one or some attribution reactions from the others to decouple their interactions existing in the reaction network,the so-called reaction decoupling enables a better understanding of the complex thermal conversion process and further the optimization of the conditions for attribution reactions as well as the entire conversion process to realize advanced performances.The dual bed conversion and two-stage conversion are the two representative types of fuel conversion technologies developed in recent years based on reaction decoupling.Many technical advantages have been proven for such decoupling fuel conversion technologies,such as poly-generation of products,low-cost production of high-grade products,elimination of undesirable products or pollutants,easy operation and control,and so on.The treated fuels with decoupling conversion technologies mainly include solid biomass and coal,as well as liquid petroleum oil.This paper is devoted to reiteration of the reaction decoupling concept and further to reviewing the research,developments and successful applications of several decoupling fuel conversion technologies of two such types by using fluidized bed as their major reactors. | Zhennan Han Sulong Geng Xi Zeng Shipei Xu a Ping An Jiguang Cheng Jun Yang Feng Li Suyi Zhang Miao Liu Guoqing Guan Guangwen Xu | 2018 | Carbon Resources Conversion2018，1，2： | 8 |
| 7 | Research on Benefit Distribution Mechanism of Farmers’ Specialized Cooperative Economic Organization显示文摘On the basis of conducting survey in Jiaonan City,the thesis analyzes benefit distribution mechanism of farmers’ specialized cooperative economic organizations:firstly,the benefit correlation is mainly the contract correlation;secondly,the profit distribution is mainly the dividend;thirdly,patronage refund has many connotations;fourthly,the public accumulation has not yet been quantified to individual;fifthly,the government support capital is ill-defined.Based on these,the measures are put forward in order to improve benefit distribution pattern of farmers’ specialized cooperative economic organizations:firstly,reform structure of property rights and realize farmers’ ownership;secondly,change mode of decision-making,and realize farmers’ control;thirdly,increase turnover rebate and realize farmers’ benefiting;fourthly,quantify public accumulation and government support fund. | SUN Hao-jie1,WANG Zheng-bing2,WANG Yun-hui3 1.School of Economics and Management,Chang’ an University,Xi’an 710064,China 2.College of Economics and Management,Northwest A & F University,Yangling 712100,China 3.Publicity Office of Party Committee,Xi’an Branch of the People’ Bank of China,Xi’an 710064,China | 2011 | Asian Agricultural Research2011，3，4： | 5 |
| 8 | Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1显示文摘聚合酶我和抄本版本因素(PTRF,也作为 Cavin-1 知道) 是在 caveolae 的生物的续生说和功能的一个必要部件。这里,我们证明那 PTRF 表情在衰老的人的成纤维细胞被增加。重要地, PTRF 的 overexpression 导致了细胞的老朽特征的特征,而减少的 PTRF 表示扩大了细胞的 replicative lifespan。有趣地,我们在细胞的老朽期间首先发现那 PTRF 局部性到年轻、静止的 WI-38 人的成纤维细胞,而是 translocated 的原子核到 cytosol 和血浆膜。而且,显微镜的分析表明了的电子 caveolar 结构在的一个增加的数字衰老并且 PTRF-transfected WI-38 房间。我们的数据建议在细胞的老朽的 PTRF 的角色依赖于它指向到有 caveolin-1 的 caveolae 和它的相互作用,它看起来被 PTRF 的 phosphorylation 调整。一起拿,我们的调查结果作为通过 p53/p21 和 caveolar 小径行动的细胞的老朽的一个新奇管理者识别 PTRF。 | Lin Bai Xiaoli Deng Juanjuan Li Miao Wang Qian Li Wei An Deli A Yu-Sheng Cong | 2011 | Cell Research2011，21，7： | 5 |
| 9 | Response characteristics of an ascending auditory neuron AN3 and its projections in the brain of the bushcricket Gampsocleis grationsa显示文摘The phonotaxis of bushcrickets demonstrates that they have goodcapability of recognizing conspecific songs and locating the sound source,which bases on complicated auditory mechanisms of the central nervoussystem(CNS).This article describes the response characteristics of AN3,an auditory ascending neuron in the prothoracic ganglion,and its projec-tions within the brain.The AN3,with a quasi-tonic discharge pattern,has high sensitivity,directionality and ability to encode sound intensity.Therefore,it plays an important role in auditory information processingof CNS.Its projections in the brain are mainly concentrated in the lateralzone of the deutencephalon,where synaptically connecting local auditoryinterneurons in the brain. | GAO Panpan and SHEN Jun -Xian(Institute of Biophysics, Academia Sinica, Beijing 100080)The phonotaxis of bushcrickets demonstrates that they have good capability of recognizing conspecific songs and locating the sound source, which bases on complicated auditory mechanisms of the central nervous system (CNS). This article describes the response characteristics of AN3, an auditory ascending neuron in the prothoracic ganglion, and its projections within the brain. The AN3 , with a quasi-tonic discharge pattern, has high sensitivity, directionality and ability to encode sound intensity. Therefore, it plays an important role in auditory information processing of CNS. Its projections in the brain are mainly concentrated in the lateral zone of the deutencephalon, where synaptically connecting local auditory interneurons in the brain. | 1992 | Chinese Journal of Acoustics1992，11，1： | 3 |
| 10 | Malakoplakia of the colon associated with colonic adenocarcinoma diagnosed in colonic biopsies显示文摘Malakoplakia, typically involving the urinary tract, is an uncommon form of chronic in? ammation caused by chronic infections and characterized by accumulation of macrophages. It has also been found in many other sites such as the gastrointestinal tract, pancreas, liver, lymph nodes, skin, respiratory tract, adrenal gland, vagina and brain. We present a case of a 64-year-old man referred to our hospital with cachexia and radiologic evidence of metastatic tumor of the liver. Colonoscopy revealed a large malignant - appearing polypoid mass of the ascending colon and multiple distinct polyps throughout the rest of the colon. Biopsies of the ascending colon mass confirmed the diagnosis of adenocarcinoma. Histological examination of two of the other polyps revealed malakoplakia which was characterized by aggregates of granular histiocytes with Michaelis - Gutmann bodies and histochemically confirmed with periodic acid-Schiff and von Kossa stains. This is a rare case diagnosed on endoscopic samples. The majority of reported cases were found in surgical specimens. In addition, the endoscopic appearance of multiple polyps is unusual in malakoplakia. | F Karasavvidou SP Potamianos S Barbanis E Stathakis A Psychos AN Kapsoritakis G Koukoulis | 2007 | World Journal of Gastroenterology2007，13，45： | 2 |
| 11 | Security Situation in Afghanistan显示文摘In the first half of 2006, the Taliban armed forces intensified their terrorist attacks in Afghanistan, thus drawing attention of the international community. The worse situation there will inevitably produce negative impacts on the security in the west regions of China. Based on a thorough analysis of the situation, the author concluded that the low-intensity conflicts there would continue in some time to come. | Dr. Fang Jinying is an Associate Professor of the Institutes of Security and Strategic Studies, China Institutes of Contemporary International Relations (CICIR). Her major academic interests are in the worldwide Islamic extremism and South Asian security. She has written a number of articles. She is also the author of The Emergency and Development of “Ethnic Chinese Issue” in Southeast Asia (2001), and coauthor of Focus on Global Ethnic Issues (2001) and Focus on World Religious Issues (2003). | 2006 | Contemporary International Relations2006，16，6： | 2 |
| 12 | Removal of enteric viruses from sewage by activated sludge treatment 显示文摘 | Clarke N A Stevenson an E | 1961 | Am J public Health1961，51，10： | 2 |
| 13 | Sharkskin-Inspired Magnetoactive Reconfigurable Acoustic Metamaterials显示文摘Most of the existing acoustic metamaterials rely on architected structures with fixed configurations,and thus,their properties cannot be modulated once the structures are fabricated.Emerging active acoustic metamaterials highlight a promising opportunity to on-demand switch property states;however,they typically require tethered loads,such as mechanical compression or pneumatic actuation.Using untethered physical stimuli to actively switch property states of acoustic metamaterials remains largely unexplored.Here,inspired by the sharkskin denticles,we present a class of active acoustic metamaterials whose configurations can be on-demand switched via untethered magnetic fields,thus enabling active switching of acoustic transmission,wave guiding,logic operation,and reciprocity.The key mechanism relies on magnetically deformable Mie resonator pillar(MRP)arrays that can be tuned between vertical and bent states corresponding to the acoustic forbidding and conducting,respectively.The MRPs are made of a magnetoactive elastomer and feature wavy air channels to enable an artificial Mie resonance within a designed frequency regime.The Mie resonance induces an acoustic bandgap,which is closed when pillars are selectively bent by a sufficiently large magnetic field.These magnetoactive MRPs are further harnessed to design stimuli-controlled reconfigurable acoustic switches,logic gates,and diodes.Capable of creating the first generation of untethered-stimuli-induced active acoustic metadevices,the present paradigm may find broad engineering applications,ranging from noise control and audio modulation to sonic camouflage. | Kyung Hoon Lee Kunhao Yu Hasan Al Ba’ba’a An Xin Zhangzhengrong Feng Qiming Wang | 2020 | Research2020，，1： | 2 |
| 14 | Potential energy curves for the X^1Σ_g^+, B^1△_g and B′~1Σ_g^+ states of C_2 using MRCI and approximate CI methods显示文摘The potential energy curves for the X1Σ g+, B1△g and B′1Σ g+ states of C2 have been studied by using MRC and approximate CI methods, and are benchmarked against the calculations of full configuration in teraction (FCI). The results obtained by MRCI method agree with the FCI very well, and even are accu rate enough to compare other approximate methods as benchmark, when the calculations of FCI ar not feasible. The approximate CI methods mentioned in this paper are reliable for treating chemica problems. | LI AnYang1, WANG YuBin2, DOU YuSheng1,3 & WEN ZhenYi1,2 1 Institute of Bio-information, Chongqing University of Post and Telecommunication, Chongqing 400065, China 2 Institute of Modern Physics, Northwest University, Xi’an 710069, China 3 Department of Physical Sciences, Nicholls State University, PO Box 2022, Thibodaux, LA 70310, U. S. A | 2007 | Science China Chemistry2007，50，5： | 2 |
| 15 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 16 | Crista termindis atrial septal and coronary sinus activation during single and dual site atrial pacing显示文摘 | Prakash A Krol RB | 1996 | PACE1996，19，： | 1 |
| 17 | Discovering rules for water demand prediction:an enhanced rough _ set approach显示文摘 | Shan N Chan C | 1996 | Engineering applications in artificial intelligence1996，9，6： | 1 |
| 18 | Ethanol increases carotenoid production in Phaffia rhodozyma 显示文摘 | Gu W L An G H Johnson E A | 1997 | Journal of Industrial Microbiology & Biotechnology1997，19，： | 1 |
| 19 | Blood pressure response to physical exertion in adolescents: influence of overweight and obesity显示文摘 | Carletti L Rodrigues AN Perez A J | 2008 | Arq Bras Cardiol2008，91，1： | 1 |
| 20 | Global strategy for thed iagnosis,m anagem ent and prevent ion of chron ic obstructivepu lm onary d isease:GOLD execu tive summ ary显示文摘 | Rabe KF H urd S An zueto A | 2007 | Am J Resp ir C rit C areM ed2007，9，6： | 1 |
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