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| 1 | Propofol Attenuates a-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke显示文摘a-Synuclein is a soluble monomer abundant in the central nervous system. Aggregates of a-synuclein,consisting of higher-level oligomers and insoluble fibrils,have been observed in many chronic neurological diseases and are implicated in neurotoxicity and neurodegeneration.a-Synuclein has recently been shown to aggregate following acute ischemic stroke, exacerbating neuronal damage.Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke. While propofol has demonstrated neuroprotective properties following brain injury, the mechanism of protection in the setting of ischemic stroke is unclear. In this study, propofol administration significantly reduced the neurotoxic aggregation of a-synuclein, decreased the infarct area, and attenuated the neurological deficits after ischemic stroke in a mouse model. We then demonstrated that the propofol-induced reduction of a-synuclein aggregation was associated with increased mammalian target of rapamycin/ribosomal protein S6 kinase beta-1 signaling pathway activity and reduction of the excessive autophagy occurring after acute ischemic stroke. | Yuzhu Wang Dan Tian Changwei Wei Victoria Cui Huan Wang Yanbing Zhu Anshi Wu Yun Yue | 2020 | Neuroscience Bulletin2020，36，3： | 14 |
| 2 | Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke显示文摘Dear Editor,Emergency intravascular thrombectomy is the best treatment for acute ischemic stroke [1]. However, it is controversial whether the use of general anesthesia during emergency intravascular thrombectomy affects patient recovery. | Yuzhu Wang Dan Tian Yushang Zhao Mengyao Qu Yuhualei Pan Changwei Wei Yanbing Zhu Anshi Wu | 2021 | Neuroscience Bulletin2021，37，5： | 3 |
| 3 | Which is more effective in adolescent idiopathic scoliosis surgery: batroxobin, tranexamic acid or a combination?显示文摘 | Chengshi Xu Anshi Wu Yun Yue | 2012 | Archives of Orthopaedic and Trauma Surgery2012，，1： | 1 |
| 4 | Hippocampal Glutamate Level and Glutamate Aspartate Transporter (GLAST) are Up-Regulated in Senior Rat Associated with Isoflurane-Induced Spatial Learning/Memory Impairment显示文摘 | Xiangdong Qu Chengshi Xu Hui Wang Jie Xu Weiran Liu Yun Wang Xingyuan Jia Zhongcong Xie Zhipeng Xu Chao Ji Anshi Wu Yun Yue | 2013 | Neurochemical Research2013，，1： | 1 |
| 5 | Effects of anesthetic propofol on release of amino acids from the spinal cord during visceral pain显示文摘 | Xiaobo Mu Anshi Wu Jing Wu Yang Liu Yongqian Zhang Yun Yue Li Fang Yun Wang | 2010 | Neuroscience Letters2010，，3： | 1 |
| 6 | Dynamic routing and wavelength assignment in multi granularity WDM networks 显示文摘 | Zhang Yu Xu Anshi Wu Deming | 2007 | Photonic Network Communications2007，13，3： | 1 |
| 7 | Novel Node Structures for IP over WDM Networks显示文摘IP over WDM is being envisioned as one of the most attractive architectures for the next generation Internet. This paper introduces two novel backbone node structures for IP over WDM networks. These node structures can be used as improvement approaches to DPDP (default path and dedicated path) method. The flow classifiers, which are the main components of these node structures, and the performance metrics of these structures, are also discussed. | 李景聪 Wu Deming Xu Anshi | 2001 | High Technology Letters2001，7，4： | 0 |
| 8 | Molecular mechanisms and the role of the protein kinase pathway in rat spatial memory impairment following isoflurane anesthesia显示文摘BACKGROUND: Animal experiments have demonstrated that isoflurane exposure alone induces learning and memory deficits for weeks or months. However, the molecular mechanisms of learning and memory remain poorly understood. Hippocampal expression of calcium/phospholipid- dependent protein kinase (PKC) and cAMP-dependent protein kinase (PKA) in rats have been shown to be associated with memory processing. OBJECTIVE: To investigate changes in rat spatial memory and hippocampal CA1 neuronal kinase system following isoflurane anesthesia, and to explore the correlation between molecular changes in cerebral neurons and behavioral manifestations following anesthesia. DESIGN, TIME AND SETTING: A randomized, controlled, animal study. All experiments were performed at the Department of Anesthesia, Beijing Chaoyang Hospital, Capital Medical University from November 2007 to December 2008. MATERIALS: A total of 72 male, 3 month-old (young group), Sprague Dawley rats, and 36 male, 20 month-old (aged group), Sprague-Dawley rats were used in the study. Isoflurane was purchased from Baxter, USA. METHODS: Young and aged rats were randomly assigned to control, training (no anesthesia, Morris water maze training), and isoflurane (1.2% isoflurane, Morris water maze training) groups. The isoflurane group was further subdivided into four groups, which were exposed to anesthesia for 2 or 4 hours, and were subjected to Morris water maze training at 2 days or 2 weeks post- anesthesia. Finally, each aged group comprised 6 rats, and the young group comprised 12 rats. MAIN OUTCOME MEASURES: Spatial learning and memory were observed during Morris water maze training. Hippocampal CA1 PKA and PKC expression and activity were detected by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA). RESULTS: A 4-hour isoflurane exposure induced spatial memory deficits in all rats for 2 days to 2 weeks. In particular, aged rats exhibited more severe spatial memory deficits. Immunohistochemistry and ELISA results showed a significant increase in PKC and PKA expression and activity in the hippocampus CA1 subfield following Morris water maze training (P < 0.05). Moreover, isoflurane anesthesia inhibited PKC and PKA expression and activity, and this inhibition increased with increasing exposure duration and increasing age. CONCLUSION: Results suggested that increased isoflurane exposure and age could extensively inhibit the hippocampal CA1 kinase system. Inhibition of protein kinases could play an important role in the cognitive decline following anesthesia. | Qing Zhang Guanyu Lu Zhipeng Xu Chunsheng Feng Anshi Wu Yun Wang Hui Wang Yun Yue | 2010 | Neural Regeneration Research2010，5，7： | 0 |
| 9 | A Pricing Model for Optical Networks显示文摘Pricing of the optical networks will play a key role from network operator's point of view to achieve the maximum profit. This paper introduces pricing models for optical networks. | Ziyu Shao, Ziyu Wang, Deming Wu, Anshi XuNational Laboratory on Local Fiber-Optic Communication Network & Advanced Optical Communication Systems, Department of Electronics, Peking University, P.R.China, Tel: 86-10-62755136, Fax: 86-10-62751763 | 2003 | 光学学报2003，23，S1： | 0 |
| 10 | A New OPS Node Structure with WDM Time-Limited RAMs显示文摘Based on a new practical optical packet buffering method, a new Optical Packet Switching node structure is designed by us. This new node structure greatly reduces the complexity of the already-existing node structures by omiting the slot-selection stage. | Shuguang Zhu, Anshi Xu, Hongxi Yin, Doming Wu, Xuzong Chen, Zhengbin LiNational Laboratory on Local Fiber-Optic Communication Network & Advanced Optical Communication Systems Department of Electronics, Peking University, P.R.China | 2003 | 光学学报2003，23，S1： | 0 |
| 11 | Scheme of a WDM Time-Limited RAM for OPS显示文摘We propose a new idea of utilizing Multiple Electromagnetically Induced Transparency Concurrence within a Single Medium to fullfill optical packet buffering and theoretically design a Wavelength Division Multiplexing (WDM) Random Access Memory (RAM). | Shuguang Zhu, Anshi Xu, Hongxi Yin, Deming Wu, Xuzong ChenNational Laboratory on Local Fiber-Optic Communication Network & Advanced Optical Communication Systems, Department of Electronics, Peking University, P.R.China, Tel: 86-10-62755136, Fax: 86-10-62751763 | 2003 | 光学学报2003，23，S1： | 0 |
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