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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | Solubilities and thermodynamic properties of gases in the ionic liquid 1-n-butyl-3-methylimidazolium hexafluorophosphate显示文摘 | Anthony J L Maginn E J Brennecke J F | 2002 | J Phys Chem B2002，106，29： | 1 |
| 4 | Splanchnic artery aneurysms显示文摘 | SHABANA F P PETER GLOVICZKL ANTHONY W | | 0，，04： | 1 |
| 5 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 6 | Optimization of launch vehicle ascent trajectories with path constraints and coast arcs显示文摘 | PETER F ANTHONY J | 2001 | Journal of Guidance Control and Dynamics2001，24，2： | 1 |
| 7 | Osmium silsesquioxane as model compound and homogeneous catalyst for the dihydroxylation of alkenes显示文摘 | PAOLO P PESCARMONA ANTHONY F MASTERS | 2004 | Journal of Molecular Catalysis A: Chemical2004，220，： | 1 |
| 8 | Perovskite anode electrocatalysts for direct methanol fuel cells显示文摘 | White J Sammells H Anthony F | 1993 | Electrochem Soc1993，140，8： | 1 |
| 9 | A matter of style:The teacher as expert,formal authority,personal model,faclilitator,and delegator显示文摘 | ANTHONY F GRASHA | | 0，，42： | 1 |
| 10 | Inequality Decomposition by Factor Components显示文摘 | Shorrocks Anthony F | 1982 | Econometfica1982，，1： | 1 |
| 11 | Tumor targeting by conjugation of DHA to paclitaxel显示文摘 | Bradley M O Stindell C S Anthony F H | 2001 | Control Release2001，74，13： | 1 |
| 12 | Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs显示文摘 | SCOTT F ANTHONY L NANCY L | 2007 | Human Molecular Genetics2007，16，1： | 1 |
| 13 | Repartition effect of aromatic polyaniline coatings on the separation of bioactive peptides in capillary electrophoresis显示文摘 | ALESSANDRA B SERGEY A P ANTHONY P F T PIER G R | 2002 | Electrophoresis2002，23，2： | 1 |
| 14 | The efficacy of in five forms of 2-4 D in controlling preharvest fruit drop citrus显示文摘 | Goldman R Anthony M F Coggins C W | 1999 | Scientia Horticulturae1999，81，3： | 1 |
| 15 | Determination of optimal capacity of resource-based recreation facilities显示文摘 | ANTHONY F KRUTILLA J | 1972 | Natural Resources Journal1972，12，3： | 1 |
| 16 | On the indusmial ecology potential in Asian Developing Countries显示文摘 | Anthony S F Chiu Geng Yong | 2004 | Journal of Cleaner Production2004，，12： | 1 |
| 17 | Strong genetic evi- dence of DCDC2 as a susceptibility gene for dyslexia显示文摘 | Schumacher J Anthoni H Dahdouh F | 2006 | Am J Hum Genet2006，78，： | 1 |
| 18 | Differenti- al expression of vasoactive mediators in microparticle- challenged lungs of chickens that differ in susceptibility to pulmonary arterial hypertension显示文摘 | Hamal K R Wideman R F Anthony N B | 2010 | Am J Physiol Regul Integr Comp Physiol2010，298，1： | 1 |
| 19 | The diagnostic accuracy of mammography in the evaluation of male breast disease 显示文摘 | Evans G F Anthony T Tumage R H et at | 2001 | Am J Surg2001，181，2： | 1 |
| 20 | Diagnosis and assessment of trachoma显示文摘 | Anthony WS Rosanna WP Allen F | 2004 | Clinl Microbiol Rev2004，17，： | 1 |
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