| 1 | An ESIPT-based NIR-fluorescent probe for exosome labeling and in situ imaging显示文摘Exosomes play significant roles in physiological and tumorigenic processes and it is desirable to visualize and track the exosomes.Herein,a novel amphiphilic fluorescent probe HBT-Exo based on excited-state intramolecular proton transfer(ESIPT)mechanism is reported for exosome-labeling.Its ESIPT characteristics were confirmed by both theory calculation and experimental observation,which enable the probe to show a large Stokes shift as well as near-infrared(NIR)keto-form emission.HBT-Exo displayed excellent biocompatibility and remarkable efficiency for exosome-labeling in gastric cancer cells.Furthermore,the labeled exosomes were successfully applied for the real-time in situ imaging in mouse models. | Jipeng Ding Runsha Xiao Anyao Bi Guanyang Chen Nengwei Zhang Zihua Chen Xueping Feng Wenbin Zeng | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
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