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| 1 | A holistic strategy for quality and safety control of traditional Chinese medicines by the “iVarious” standard system显示文摘An effective quality control system is the key to ensuring the quality, safety and efficacy of traditional Chinese medicines(TCMs). However, the current quality standard research lacks top-level design and systematic design,mostly based on specific technologies or evaluation methods. To resolve the challenges and questions of quality control of TCMs, a brand-new quality standard system, named 'iVarious', was proposed. The system comprises eight elements in a modular format. Meaning of every element was specifically illustrated via corresponding research instances. Furthermore, frankincense study was taken as an example for demonstrating standards and research process, based on the 'i Various' system. This system highlighted a holistic strategy for effectiveness,security, integrity and systematization of quality and safety control standards of TCMs. The establishment of'i Various' integrates multi-disciplinary technologies and progressive methods, basis elements and key points of standard construction. The system provides a novel idea and technological demonstration for regulation establishment of TCMs quality standards. | Anzhen Chen Lei Sun Hang Yuan Aiying Wu Jingguang Lu Shuangcheng Ma | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 16 |
| 2 | A prospective randomized antiplatelet trial of cilostazol versus clopidogrel in patients with bare metal stent显示文摘Background Cilostazol is a newly developed antiplatelet drug that has been widely applied for clinical use. Its antiplatelet action appears to be mainly related to inhibition of intracellular phosphodiesterase activity. Recently, cilostazol has been used for antiplatelet therapy after coronary bare metal stent implantation for thrombosis and restenosis prevention. This prospective randomized and double blind trial was designed to investigate the safety and efficacy of cilostazol for the prevention of late restenosis and acute or subacute stent thrombosis. Methods One hundred and twenty patients who underwent elective stent were randomly assigned to treatment group with cilostazol 200 mg/d (n = 60), clopidogrel 75 mg/d and aspirin 100 mg/d or to control group with clopidogrel treatment 75 mg/d (n = 60) and aspirin 100 mg/d. Follow-up coronary angiography was performed 6-9 months later. Results Nine months major adverse cardio-cerebral event (MACCE) were lower in treatment groups (P<0.05). The quantitative coronary angiography (QCA) at 6 months follow-up showed that minimum lumen diameter (MLD) was higher in treatment group than that of control group [(2.14±0.52)mm vs (1.82±0.36)mm, P<0.05]. Late lumen loss (LL) [(0.82±0.42)mm vs (1.31±0.58)mm; P<0.01], restenosis rate (RR) (14% vs 32%; P<0.05) and target lesion revascularizaion (TLR) rate (5% vs 17%; P<0.05) were lower in treatment group than in control group. Conclusion Cilostazol therapy is an effective regimen for prevention not only stent thrombosis but also RR and TLR through reducing MLD without the risk of increasing bleeding. | CHEN Yun-dai, LU Yan-ling, JIN Ze-ning, YUAN Fei and Lü Shu-zhengDepartment of Cardiology, Beijing Anzhen Hospital, Capital University of Medical Sciences Beijing Institute of Heart, Lung and Blood Vessel, Beijing 100029, China | 2006 | Chinese Medical Journal2006，，5： | 15 |
| 3 | Combined genomic, transcriptomic, and metabolomic an alyses provide in sights into chayote (Sechium edule) evolution and fruit development显示文摘Chayote(Sechium edule)is an agricultural crop in the Cucurbitaceae family that is rich in bioactive components.To enhance genetic research on chayote,we used Nanopore third-generation sequencing combined with Hi-C data to assemble a draft chayote genome.A chromosome-level assembly anchored on 14 chromosomes(N50 contig and scaffold sizes of 8.40 and 46.56 Mb,respectively)estimated the genome size as 606.42 Mb,which is large for the Cucurbitaceae,with 65.94%(401.08 Mb)ofthe genome comprising repetitive sequences;28,237 protein-coding genes were predicted.Comparative genome analysis indicated that chayote and snake gourd diverged from sponge gourd and that a whole-genome duplication(WGD)event occurred in chayote at 25±4 Mya.Transcriptional and metabolic analysis revealed genes involved in fruit texture,pigment,fl avor,fl avonoids,antioxidants,and plant hormones during chayote fruit development.The analysis of the genome,transcriptome,and metabolome provides insights into chayote evolution and lays the groundwork for future research on fruit and tuber development and genetic improvements in chayote. | Anzhen Fu Qing Wang Jianlou Mu Lili Ma Changlong Wen Xiaoyan Zhao Lipu Gao Jian Li Kai Shi Yunxiang Wang Xuechuan Zhang Xuewen Zhang Fengling Wang Donald Grierson Jinhua Zuo | 2021 | Horticulture Research2021，8，1： | 6 |
| 4 | Transcriptomics and metabolomics analyses provide insights into postharvest ripening and senescence of tomato fruit under low temperature显示文摘Tomato is one of the most important vegetable crops in the world and is a model plant used to study the ripening of climacteric fleshy fruit.During the ripening process of tomato fruit,flavor and aroma metabolites,color,texture and plant hormones undergo significant changes.However,low temperatures delayed the ripening process of tomato fruit,inhibiting flavor compounds and ethylene production.Metabolomics and transcriptomics analyses of tomato fruit stored under low temperature(LT,5°C)and room temperature(RT,25°C)were carried out to investigate the effects of storage temperature on the physiological changes in tomato fruit after harvest.The results of transcriptomics changes revealed that the differentially expressed genes(DEGs)involved in tomato fruit ripening,including several kinds of transcription factors(TFs)(TCP,WRKY,MYB and bZIP),enzymes involved in cell wall metabolism[beta-galactosidase(β-GAL),pectinesterase(PE)and pectate lyase(PL),cellulose and cellulose synthase(CESA)],enzymes associated with fruit flavor and aroma[acetyltransferase(AT),malic enzyme(ME),lipoxygenase(LOX),aldehyde dehydrogenase(ALDH),alcohol dehydrogenase(ADH)and hexokinase(HK)],genes associated with heat stress protein 70 and genes involved in the production of plant hormones such as Ethylene responsive factor 1(ERF1),Auxin/indoleacetic acids protein(AUX/IAA),gibberellin regulated protein.Based on the above results,we constructed a regulatory network model of the effects of different temperatures during the fruit ripening process.According to the analysis of the metabolomics results,it was found that the contents of many metabolites in tomato fruit were greatly affected by storage temperature,including,organic acids(L-tartaric acid,a-hydroxyisobutyric acid and 4-acetamidobutyric acid),sugars(melezitose,beta-Dlactose,D-sedoheptulose 7-phosphate,2-deoxyribose 1-phosphate and raffinose)and phenols(coniferin,curcumin and feruloylputrescine).This study revealed the effects of storage temperature on postharvest tomato fruit and provided a basis for further understanding of the molecular biology and biochemistry of fruit ripening. | Chunmei Bai Caie Wu Lili Ma Anzhen Fu Yanyan Zheng Jiawei Han Changbao Li Shuzhi Yuan Shufang Zheng Lipu Gao Xinhua Zhang Qing Wang Demei Meng Jinhua Zuo | 2023 | Horticultural Plant Journal2023，9，1： | 3 |
| 5 | The genome and transcriptome analysis of snake gourd provide insights into its evolution and fruit development and ripening显示文摘Snake gourd(Trichosanthes anguina L.),which belongs to the Cucurbitaceae family,is a popular ornamental and food crop species with medicinal value and is grown in many parts of the world.Although progress has been made in its genetic improvement,the organization,composition,and evolution of the snake gourd genome remain largely unknown.Here,we report a high-quality genome assembly for snake gourd,comprising 202 contigs,with a total size of 919.8 Mb and an N50 size of 20.1 Mb.These findings indicate that snake gourd has one of the largest genomes of Cucurbitaceae species sequenced to date.The snake gourd genome assembly harbors 22,874 protein-coding genes and 80.0%of the genome consists of repetitive sequences.Phylogenetic analysis reveals that snake gourd is closely related to sponge gourd but diverged from their common ancestor~33–47 million years ago.The genome sequence reported here serves as a valuable resource for snake gourd genetic research and comparative genomic studies in Cucurbitaceae and other plant species.In addition,fruit transcriptome analysis reveals the candidate genes related to quality traits during snake gourd fruit development and provides a basis for future research on snake gourd fruit development and ripening at the transcript level. | Lili Ma Qing Wang Jianlou Mu Anzhen Fu Changlong Wen Xiaoyan Zhao Lipu Gao Jian Li Kai Shi Yunxiang Wang Xuewen Zhang Xuechuan Zhang Zhangjun Fei Donald Grierson Jinhua Zuo | 2020 | Horticulture Research2020，7，1： | 2 |
| 6 | Yield photosynthesis and leaf anatomy of maize in inter-and mono-cropping systems at varying plant densities显示文摘Increasing plant density can increase cereal crop yields. However, the physiological and anatomical mechanisms of grain yield increase at high plant densities in maize-based intercropping systems are not well understood. A two-year field experiment was conducted in 2018 and 2019 to investigate grain yield, photosynthetic characteristics, stomatal traits, and leaf anatomy of maize plants in an intercropping system with high plant densities. Two cropping patterns(monocropping and intercropping) and three plant densities(D1, 78,000 plants ha^(-1);D2, 103,500 plants ha^(-1);D3, 129,000 plants ha;were arranged in a randomized block design. Increasing maize plant density significantly increased maize yield, and intercropping gave a significant yield advantage over monocropping under the same plant density. Intercropping combined with high plant density increased the leaf area and SPAD value of maize,increasing the photosynthesis rates after the harvest of pea. At the twelfth leaf stage, the stomatal density and stomatal area of intercrops combined with medium plant density increased by respectively 10.5%and 18.4% relative to their values for the corresponding density of monocrops. Although leaf thickness of maize was reduced by increasing plant density, the chloroplast number and grana lamella number were higher in intercropping than in monocropping under different plant densities. These positive changes in leaf anatomy resulted in increased photosynthesis, suggesting a physiological basis for the increase in grain yield. | Hongwei Yang Qiang Chai Wen Yin Falong Hu Anzhen Qin Zhilong Fan Aizhong Yu Cai Zhao Hong Fan | 2022 | The Crop Journal2022，10，3： | 2 |
| 7 | Regulations of m^(6)A methylation on tomato fruit chilling injury显示文摘Tomato fruit are sensitive to chilling injury(CI)during cold storage.Several factors have been discovered to be involved in chilling injury of tomato fruit.Plant hormones play an important regulatory role,however,the relationship between chilling injury and N6-methyladenosine(m^(6)A)methylation of transcripts in plant hormone pathways has not been reported yet.In order to clarify the complex regulatory mechanism of m^(6)A methylation on chilling injury in tomato fruit,Nanopore direct RNA sequencing was employed.A large number of enzymes and transcription factors were found to be involved in the regulation process of fruit chilling injury,which were associated with plant hormone,such as 1-aminocyclopropane 1-carboxylate synthase(ACS),aspartate aminotransferase(AST),auxin response factor(ARF2),ethylene response factor 2(ERF2),gibberellin 20-oxidase-3(GA20ox)and jasmonic acid(JA).By conjoint analysis of the differential expression transcripts related to chilling injury andm^(6)Amethylation differential expression transcripts 41 differential expression transcripts were identified involved in chilling injury including 1-aminocyclopropane-1-carboxylate oxidase(ACO)and pectinesterase(PE)were down-regulated and heat shock cognate 70 kD protein 2(cpHSC70),HSP70-binding protein(HspBP)and salicylic acid-binding protein 2(SABP2)were up-regulated.Our results will provide a deeper understanding for chilling injury regulatory mechanism and post-harvest cold storage of tomato fruit. | Chunmei Bai Minghuan Fang Baiqiang Zhai Lili Ma Anzhen Fu Lipu Gao Xiaohong Kou Demei Meng Qing Wang Shufang Zheng Jinhua Zuo | 2021 | Horticultural Plant Journal2021，7，5： | 2 |
| 8 | Effect of low molecular weight organic acids on adsorption and desorptionof fluoride on variable charge soils显示文摘 | Renkou Xu Yayun Wang Anzhen Zhao Guoliang Ji Hong Zhang | 2006 | Environmental Geochemistry and Health2006，，1： | 1 |
| 9 | Effect of low molecular weight organic acids on adsorption and desorption of fluoride on variable charge soils显示文摘 | Renkou Xu Yayun Wang Anzhen Zhao Guoliang Ji Hong Zhang | 2006 | Environmental Geochemistry and Health (-)2006，，1： | 1 |
| 10 | pH buffering capacity of acid soils from tropical and subtropical regions of China as influenced by incorporation of crop straw biochars显示文摘 | XU Renkou ZHAO Anzhen YUAN Jinhua a al | | 0，，04： | 1 |
| 11 | Effect of low molecular weight organic acids on adsorption and desorption of fluoride on variable charge soils显示文摘 | Xu Renkou Wang Yayun Zhan Anzhen | 2006 | Environmental Geochemistry and Health2006，28，： | 1 |
| 12 | Prevalence of chronic obs-tructive pulmonary disease in China: a large, population-based survey显示文摘 | Nanshan Zhong Chen W ang W anzhen Yao | 2007 | Am J Respir CritCareMed2007，176，8： | 1 |
| 13 | Synergistic effects of hydroxides and dimethyl methylphosphonate on rigid halogen‐free and flame‐retarding polyurethane foams显示文摘 | Anzhen Zhang Yihe Zhang Fengzhu Lv Paul K. Chu | 2012 | J. Appl. Polym. Sci2012，，1： | 1 |
| 14 | Effect of low-molecular-weight organic anions on surface charge of variable charge soil 显示文摘 | Xu Renkou Zhao Anzhen Ji Guoliang | 2003 | Journal of Colloid and Interface Science2003，264，： | 1 |
| 15 | 显示文摘 | AnZhen(安震) LiJinshan(李金山) FengYong(冯勇)etal | 2015 | 稀有金属材料与工程2015，44，1： | 1 |
| 16 | Author's reply显示文摘To the Editor:We read with great interest the letterfrom Drs.Finsterer and Stllberger,on our casereport.We are grateful to their comments.It is not uncommon that the adult patients with theecho-characteristics of left ventricular noncompactionmet in our practice the criteria proposed by Oechslin andhis colleagues.The left ventricular dilation and | JIANG Teng·yongDePartment of Cardiology, Beijing Anzhen HosPital,Beijing 100029,China | 2007 | Chinese Medical Journal2007，，18： | 0 |
| 17 | Self-enhancing photothermal conversion of 2D Weyl semimetal WTe_(2)with topological surface states for efficient solar vapor generation显示文摘To improve the performance of solar energy-driven water generation,two-dimensional(2D)photothermal materials requisite to be optimized by some strategies such as alloying,combination of plasmonic and defect modulation.However,the challenges faced in practical utilization are the complex preparation process and insufficient solar spectrum absorption.Herein,we propose a strategy of self-enhancing photothermal performance induced by topological surface states(TSSs).2D WTe_(2)is fabricated on the mixed cellulose ester(MCE)for photothermal device.Compared to the MCE and pure water,WTe_(2)@MCE has an excellent photothermal evaporation rate of 1.09 kg·m^(−2)·h^(−1)upon 1 sun irradiation,promoting 6.1 and 3.1 times,respectively.It can be attributed to the characteristics of 2D Weyl semimetal WTe_(2)with TSSs bringing about high optical absorption capacity,low thermal diffusivity,specific heat capacity,and high carrier density,which are strongly proved by experiments and calculation.More importantly,the contribution of TSSs to the enhancement of optical absorption for efficient solar water generation is revealed by the comparative experiment between 2D WTe_(2)with TSSs and that without TSSs.Furthermore,photothermal conversion mechanism is explored in-depth understanding that the photoexcited electrons recombinate with the holes through nonradiative mode for releasing thermal energy by phonons emission via multiple pathway.This work promotes the application of Weyl semimetal material with TSSs in solar water evaporation. | Chun Du Ziyi Yang Anzhen Mo Xuanming Duan Guowei Yang | 2023 | Nano Research2023，16，8： | 0 |
| 18 | Global existence and time decay rates for the 3D bipolar compressible Navier-Stokes-Poisson system with unequal viscosities显示文摘We consider the Cauchy problem for the three-dimensional bipolar compressible Navier-Stokes-Poisson system with unequal viscosities.Under the assumption that the H_(3) norm of the initial data is small but its higher order derivatives can be arbitrarily large,the global existence and uniqueness of smooth solutions are obtained by an ingenious energy method.Moreover,if additionally,the H^(−s)(1/2≤s<3/2)or B^(−s)_(2,∞)(1/2 | Guochun Wu Yinghui Zhang Anzhen Zhang | 2022 | Science China Mathematics2022，65，4： | 0 |
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