| 1 | TDF Promotes Glycolysis and Mitochondrial Dysfunction to Accelerate Lactate Accumulation by Downregulating PGC1α in Mice显示文摘Tenofovir disoproxil fumarate(TDF),is a product of tenofovir and has been recommended for long-term use by guidelines1 because of its favorable efficacy in the treatment of human immunodeficiency virus(HIV)and hepatitis B virus(HBV)infection.Hence,a better understanding of the safety profiles of long-term TDF use is extremely important.Lactic acidosis,as a rare but fatal adverse event of TDF,were reported both in HIV-infected patients,2-4 and in CHB patients.5-7 Hyperlactatemia occurred in 15.6%HIV-infected patients using TDF in a Cameroon cohort study8 and was 3%in another South Africa cohort study.9 Therefore,TDF increases the risk of abnormal serum lactate,but the mechanism is unclear. | Yuxuan Luo Zhiwei Chen Zhao Li Aoran Luo Yi Zeng Min Chen Mingli Peng Hong Ren Peng Hu | 2023 | Journal of Clinical and Translational Hepatology2023，11，4： | 0 |
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