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| 1 | Hepatitis B virus genotypes and hepatocellular carcinoma in Thailand显示文摘AIM: The role of hepatitis B virus (HBV) genotypes on the clinical features and prognosis of patients with hepatocellular carcinoma (HCC) is currently unknown. The aim of the present study was to evaluate the distribution of HBV genotypes and their clinical relevance in Thai patients.METHODS: HBV genotypes were determined by PCR-RFLP in stored sera of 93 asymptomatic carriers, 103 patients with chronic hepatitis, 60 patients with cirrhosis and 76patients with HCC. The clinical data were analyzed in relation to the HBV genotype.RESULTS: HBV genotypes C and B were predominant in Thailand, accounting for 73% and 21%, respectively. The distributions of genotypes B and C were similar in HCC patients compared to the other groups. Genotype C was significantly more common in HCC patients who were under 40 years old than genotype B (18% vs 0%, P= 0.03), but was significantly less common in patients older than 60 years (26% vs 56.5%, P= 0.01). The positive rate of hepatitis B e antigen (HBeAg) in patients with genotype C was significantly higher than that in patients with genotype B (71.6% vs 44.4%, P = 0.03 in chronic hepatitis; 56.8% vs 11.1%,P = 0.01 in cirrhosis). There were no differences between HCC patients with genotypes B and C regarding tumor staging by CLIP criteria and the overall median survival. Multivariate analyses showed that HBV genotype was not an independent prognostic factor of survival in HCC patients.CONCLUSION: Patients with genotype C had a higher positive rate of HBeAg and exhibited earlier progression of cirrhosis and HCC than those with genotype B. However,there were no differences in the risk of developing HCC and its prognosis between patients with these genotypes. | Pisit Tangkijvanich Varocha Mahachai Piyawat Komolmit Juthatip Fongsarun Apiradee Theamboonlers Yong Poovorawan | 2005 | World Journal of Gastroenterology2005，11，15： | 17 |
| 2 | Role of serum interleukin-18 as a prognostic factor in patients with hepatocellular carcinoma显示文摘AIM:To determine whether serum interleukin-18 (IL-18) levels correlated with clinicopathologic features and prognosis in patients with hepatocellular carcinoma (HCC). METHODS:Serum IL-18,IL-6 and IL-12 levels were measured by enzyme-linked immunosorbent assay (ELISA) from 70 patients with HCC and 10 healthy controls. RESULTS:Serum IL-18,IL-6 and IL-12 levels of patients with HCC were significantly higher that those of the controls. The levels of IL-18 correlated significantly with the presence of venous invasion and advanced tumor stages classified by Okuda's criteria. Patients with high serum IL-18 levels (≥ 105 pg/mL) had a poorer survival than those with low serum IL-18 levels (< 105 pg/mL) (4 and 11 mo,respectively,P = 0.015). Multivariate analyses showed that serum IL-18 level,but not IL-6 and IL-12 levels,was a significant and independent prognostic factor of survival. CONCLUSION:These findings demonstrate that serum IL-8 may a useful biological marker of tumor invasiveness and an independent prognostic factor of survival for patients with HCC. Thus,the detailed mechanisms of IL-18 involving in tumor progression should be further investigated. | Pisit Tangkijvanich Duangporn Thong-ngam Varocha Mahachai Apiradee Theamboonlers Yong Poovorawan | 2007 | World Journal of Gastroenterology2007，13，32： | 15 |
| 3 | Diagnostic role of serum interleukin-18 in gastric cancer patients显示文摘瞄准:在胃的癌症病人的各种各样的方面决定当前的地位并且在泰国病人与浆液 interleukins 的预示的角色发现临床的关联。方法:68 个病人在 2003 年 4 月期间在楚拉隆克恩国王纪念物医院在这研究被注册到 2005 年 5 月。胃的癌症组织学地在 17 个病人在 51 个病人和胃溃疡被证明。浆液 IL-6, IL-10, IL-12,和 IL-18 层次被连接酶的免疫吸着剂试金(ELISA ) 测量。结果:有 26 男性(55.32%) 和 21 女性(44.68%) ,他们的年龄从 33 ~ 85 年(意味着年龄 64.49 +/- 13.83 年) 。普通演讲是重量损失(41.2%) ,消化不良(39.2%) ,并且上面的胃肠的流血 15.7%) 。35.3% 胃的癌症病人的一个总数并且 6.3% 胃溃疡病人是吸烟者(P = 0.029 ) 。而且, 32.4% 胃的癌症病人和 6.3% 胃溃疡病人是含酒精的喝酒者(P = 0.044 ) 。损害地点在 39.4% 是幽门窦的,在 39.4% 的胃的身体,在 12.2% 的上面的胃和在 6.1% 病人的全部胃。H pylori 感染在 44.4% 被检测。糟糕区分的腺癌是最普通的病理学的发现(60.7%) 。外科疗法在 44.1% 病人被执行(在 5.9% 的全胃切除术,在 32.4% 的大部胃切除术和 palliative 在 5.9% 绕过外科) 。全身的化疗在 8.8% 病人作为辅助治疗被给。癌病 peritoneii 在 18.8% 病人被发现。吝啬的生存时间是 13.03 +/- 9.75 瞬间。在胃的癌症病人组的 IL-18 水平(58.54 +/- 43.96 pg/mL ) 在胃溃疡病人组比那显著地高(30.84 +/- 11.18 pg/mL )(P = 0.0001 )(95% CI 是 42.20, 13.19 ) 。为胃的癌症的诊断的 IL-18 的伤口点是 40 pg/mL,积极预兆的价值是 92.31% 。在有远转移的胃的癌症病人的 IL-6 水平(20.21 +/- 9.37 pg/mL ) 在没有转移的那些比那显著地高(10.13 +/- 7.83 pg/mL )(P = 0.037 )(95% CI 是 19.51, 0.65 ) 。在胃的癌症病人的 IL-10 和 IL-12 层次的角色是没有有效差量提供数据。结论:这些调查结果表明那浆液 IL-6 和 IL-18,然而并非 IL-10 和 IL-12 层次可以在有胃的癌症的病人是临床的关联和预示的因素的有用生物标记。而且, IL-18 能与高积极的预兆的价值为胃的癌症用作一个诊断标记。 | Duangporn Thong-Ngam Pisit Tangkijvanich Rungsun Lerknimitr Varocha Mahachai Apiradee Theamboonlers Yong Poovorawan | 2006 | World Journal of Gastroenterology2006，12，28： | 13 |
| 4 | Virological course of hepatitis A virus as determined by real time RT-PCR: Correlation with biochemical, immunological and genotypic profiles显示文摘瞄准:承担肝炎 A 的分析,并且相关病毒的负担,丙氨酸 aminotransferase (中高音) ,和有病毒血的持续时间的病毒的遗传型有控制调停房间的免疫的 CD4 (+)/ CD8 (+) 淋巴细胞人口的这些参数。方法:房间计数用用荧光在乙二胺四乙酸小瓶收集的新鲜全血被执行激活的房间 sorter。肝炎 A 病毒(HAV ) RNA 从血浆液被提取,抄录进 cDNA 并且由实时聚合酶链反应确定了并且是 genotyped 的颠倒。结果:在 11 个病人之中, 10 能完全被分析。这些, 3 有严重尖锐肝炎(s -- 啊) 并且剩余物有自我限制尖锐肝炎 A (啊哈) ,在第 4 d 上与有暴发性的疾病(脑病等级 IV ) 的一个病人一起死。中高音水平在啊哈两个都是显著地更高的(1070.9 +/- 894.3;P = 0.0014 ) 并且 s -- 啊(1713.9 +/- 886.3;P = 0.001 ) 与正常控制相比(23.6 +/- 7.2 ) 。在 s 的前凝血酶时间 -- 啊病人(21.0 +/- 2.0;P = 0.02 ) 比在啊哈显著地高(14.3 +/- 1.1;P = 0.44 ) 。在啊哈病人的 CD4 (+)/CD8 (+) 比率(1.17 +/- 0.11;P = 0.22 ) 并且 s -- 啊(0.83 +/- 0.12;P = 0.0002 ) 比在正常健康控制(1.52 ) 看低。有的自我限制盒子达到顶点在分析的开始的病毒的负担当时在 s -- 啊病人这发生在第 15 或第 30 d。在敏锐、严格的组,一耐心的各个属于遗传型 IA,与仍然是 8 个盒子属于遗传型 IIIA。唯一的暴发性的肝的失败大小写属于遗传型 IA。在自我限制感染的全部功课期间收集的 HAV 病毒的负担和中高音价值直接为 s 被相关,但是这不是事实 -- 啊病人。结论:基于小规模的研究, s 的固执地更高的病毒的负担 -- 啊可能由于减少的细胞免疫和溶血。病毒血的持续时间依赖于主人,当病毒的遗传型没在 AVH 和 s 的临床的结果有明显的角色 -- 啊盒子。 | Zahid Hussain Bhudev C Das Syed A Husain Sunil K Polipalli Tanzeel Ahmed Nargis Begum Subhash Medhi Alice Verghese Mohammad Raish Apiradee Theamboonlers Yong Poovorawan Premashis Kar | 2006 | World Journal of Gastroenterology2006，12，29： | 10 |
| 5 | C-reactive protein and diabetic retinopathy in Chinese patients with type 2 diabetes mellitus显示文摘AIM:To investigate the relationship between Creactive protein(CRP)and diabetic retinopathy(DR)in a cohort of Chinese patients with type 2 diabetes mellitus(T2DM).·METHODS:Community-based observational cohort study.There were 1131 participants recruited from November 2009 to September 2011 in Desheng community in urban Beijing.Patients diagnosed T2DM were recruited and underwent a standardized evaluation consisting of a questionnaire,ocular and anthropometric examinations and laboratory investigation.The presence and severity of DR were assessed by seven fields 30°color fundus photographs.Subjects were then classified into groups with no DR,any DR,or vision-threatening DR.CRP was analyzed from serum of study subjects.·RESULTS:A total of 1007 patients with T2DM were included for analysis,including 408(40.5%)men and 599(59.5%)women.The median CRP level was 1.5 mg/L for women and 1.1 mg/L for men(P=0.004,OR 0.37,95%CI0.18-0.74).After adjusting for possible covariates,higher levels of CRP were associated with lower prevalence of any DR(P=0.02,OR 0.55,95%CI 0.35-0.89),but not associated with vision-threatening DR(P=0.62,OR 0.78,95%CI 0.28-2.14).After stratification by sex,the inverseassociation between CRP and DR was found to be statistically significant in men(P=0.006,OR 0.35,95%CI0.16-0.73),but not in women(P=0.58,OR 0.88,95%CI0.29-1.16).·CONCLUSION:The data drawn from a Chinese population with T2DM suggest that increasing CRP levels may be inversely associated with development of DR. | Xiu-Fen Yang Yu Deng Hong Gu Apiradee Lim Torkel Snellingen Xi-Pu Liu Ning-Li Wang Amitha Domalpally Ronald Danis Ning-Pu Liu | 2016 | International Journal of Ophthalmology(English edition)2016，9，1： | 6 |
| 6 | 护士心理契约破裂研究进展显示文摘文章综述了国内外心理契约破裂的研究现状,指出了导致护士心理契约破裂的因素,包括工作要求过高;工作资源过少;权、责、利理解偏差;积极情感缺失;消极情感旺盛。在此基础上,提出护士心理契约破裂的预防与应对措施,包括合理、明确的工作要求;公平、公正的工作资源;打消对权、责、利的理解偏差;鼓励积极情感;预防消极情感。 | 胡秋兰 马芳 杨名钫 白阳娟 Apiradee Nantsupawat | 2019 | 护理管理杂志2019，19，3： | 5 |
| 7 | Use of Cataract Surgery in Urban Beijing: a Post Screening Follow-up of the Elderly with Visual Impairment due to Age-related Cataract显示文摘Objective To understand the perception for the use of cataract surgical services in a population of acceptors and non-acceptors of cataract surgery in urban Beijing. Methods From a community-based screening program a total of 158 patients with presenting visual acuity of less than 6/18 on either eye due to age-related cataract were informed about the possibility of surgical treatment. These patients were interviewed and re-examined 36 to 46 months after initial screening. The main reasons for not accepting surgery were obtained using a questionnaire. Vision function and vision-related quality of life scores were assessed in those who received and did not receive surgery. Results At the follow-up examination 116 of the 158 patients were available and 36(31.0%) had undergone cataract surgery. Cases who chose surgery had higher education level than those who did not seek surgery(OR=2.64, 95% CI: 1.08-6.63, P=0.02). There were no significant differences in vision function(P=0.11) or quality of life scores(P=0.16) between the surgery group and the non-surgery group. Main reasons for not having surgery included no perceived need(50.0%), feeling of being 'too old'(19.2%), and worry about the quality of surgery(9.6%). Cost was cited by 1(1.9%) subject as the main reason for not seeking surgery.Conclusions The data suggest that in China's capital urban center for patients with moderate visual impairment there is a relative low acceptance rate of cataract surgery, mainly due to people's perception of marginal benefits of surgery. Cost is not a determining factor as barrier to undergo surgery and patients with poorer education are less likely to undertake surgery. | Xue-tao Ren Torkel Snellingen Hong Gu Sawitri Assanangkornchai Yan-hong Zou Virasakdi Chongsuvivatwong Apiradee Lim Wei Jia Xi-pu Liu Ning-pu Liu | 2015 | Chinese Medical Sciences Journal2015，30，1： | 5 |
| 8 | Association of C(-106)T Polymorphism in Aldose Reductase Gene with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes Mellitus显示文摘Objective To identify the possible association between C(-106)T polymorphism of the aldose reductase(ALR) gene and diabetic retinopathy(DR) in a cohort of Chinese patients with type 2 diabetes mellitus(T2DM).Methods From November 2009 to September 2010,patients with T2DM were recruited and assigned to DR group or diabetic without retinopathy(DWR) group according to the duration of diabetes and the grading of 7-field fundus color photographs of both eyes.Genotypes of the C(-106)T polymorphism(rs759853) in ALR gene were analyzed using the MassARRAY genotyping system and an association study was performed.Results A total of 268 T2DM patients(129 in the DR group and 139 in the DWR group) were included in this study.No statistically significant differences were observed between the 2 groups in the age of diabetes onset(P=0.10) and gender(P=0.78).The success rate of genotyping for the study subjects was 99.6%(267/268),with one case of failure in the DR group.The frequencies of the T allele in the C(-106)T polymorphism were 16.0%(41/256) in the DR group and 19.4%(54/278) in the DWR group(P=0.36).There was no significant difference in the C(-106)T genotypes between the 2 groups(P=0.40).Compared with the wild-type genotype,odds ratio(OR) for the risk of DR was 0.7(95% CI,0.38-1.3) for the heterozygous CT genotype and 0.76(95% CI,0.18-3.25) for the homozygous TT genotype.The risk of DR was positively associated with microalbuminuria(OR=4.61;95% CI,2.34-9.05) and insulin therapy(OR=3.43;95% CI,1.94-6.09).Conclusions Microalbuminuria and insulin therapy are associated with the risk of DR in Chinese patients with T2DM.C(-106)T polymorphism of the ALR gene may not be significantly associated with DR in Chinese patients with T2DM. | Yu Deng Xiu-fen Yang Hong Gu Apiradee Lim Munkhtulga Ulziibat Torkel Snellingen Jun Xu Kai Ma Ning-pu Liu | 2014 | Chinese Medical Sciences Journal2014，29，1： | 4 |
| 9 | Multiplex real-time RT-PCR for detecting chikungunya virus and dengue virus显示文摘Objective:To develop diagnostic test for detection chikungunya virus(CHIKV and Dengue virus (DENV) infection.Methods:We have performed a rapid,accurate laboratory confirmative method to simultaneously detect,quantify and differentiate CHIKV and DENV infection by single-step multiplex real-time RT-PCR.Results:The assay’s sensitivity was 97.65%,specificity was 92.59% and accuracy was 95.82%when compared to conventional RT-PCR.Additionally,there was no cross-reaction between CHIKV,DENV,Japanese encephalitis virus,hepatitis C,hepatitis A or hepatitis E virus.Conclusions:This rapid and reliable assay provides a means for simultaneous early diagnosis of CHIKV and DENV in a single-step reaction. | Piyathida Pongsiri Kesmanee Praianantathavorn Apiradee Theamboonlers Sunchai Payungporn Yong Poovorawan | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，5： | 3 |
| 10 | There is no association between K469E ICAM-1 gene polymorphism and biliary atresia显示文摘AIM: To determine whether there was an association between inter-cellular adhesion molecule-1 (ICAM-1) gene polymorphism and biliary atresia (BA), and to investigate the relationship between serum soluble ICAM-1 (sICAM-1)and clinical outcome in BA patients after surgical treatment.METHODS: Eighty-three BA patients and 115 normal controls were genotyped. K469EICAM-1 polymorphism was analyzed using PCR assay. Serum sICAM-1 was determined using ELISA method from 72 BA patients. In order to evaluate the association between these variables and their clinical outcome, the patients were categorized into two groups:patients without jaundice and those with persistent jaundice.RESULTS: There were no significant differences between BA patients and controls in terms of gender, K469E ICAM-1genotypes, and alleles. The proportion of patients having serum sICAM-1 ≥3 500 ng/mL in persistent jaundice group was significantly higher than that in the other group. In addition, there was no association between K469EICAM-1polymorphism and the status of jaundice in BA patients after Kasai operation.CONCLUSION: ICAM-1 possibly plays an important and active role in the disease progression. However, the process is not associated with genetic variation of K469EICAM-1 polymorphism. | Paisam Vejchapipat Naruemol Jirapanakom Nutchanart Thawornsuk Apiradee Theamboonlers Voranush Chongsrisawat Soottiporn Chittmittrapap Yong Poovorawan | 2005 | World Journal of Gastroenterology2005，11，31： | 3 |
| 11 | The diurnal variation pattern of choroidal thickness in macular region of young healthy female individuals using spectral domain optical coherence tomography显示文摘AIMTo 调查模式日报 32 健康女性的未来的学习使遭到的 healthyindividuals.METHODSA 的有斑点的区域的 choroidal 厚度的变化被进行。每个题目经历了 1 )每日的时间表上的一张问询表, 2 )匹兹堡睡觉质量索引问询表( PSQI ),并且 3 )包括眼睛优势的眼睛的考试测试,宫底摄影,和顺序的光连贯断层摄影术(10月)成像,在在五固定 3h 时间间隔的二分开的天。Choroidal 厚度被二掩盖的 graders.RESULTSA 测量重要日报在窝的 choriodal 厚度的变化(P< 0.001 ) ,在 500 µ m 鼻音(P< 0.001 ) ,对窝(P=0.01 ) 或 1500 µ 时间;对窝(P=0.001 ) 鼻的 m 被观察。中部的 choroidal 厚度在窝(P=0.01 ) 在 11:00 达到顶点,在 500 µ m 鼻音(P=0.009 ) 并且时间(P=0.03 ) 到窝。foveal choroidal 厚度的中部的振幅是 20.5 µ m (13, 31 ) 并且 20.0 µ m (12.5, 28.2 ) 为大小的第一和第二个系列分别地。 foveal choroidal 厚度的更大的振幅与 thickner 被联系起始的 foveal choroidal 厚度[ 0.05 ( 0.03 , 0.08 ), P=0.01 ],主导的眼睛[ 10.51 ( 4.02 , 14.60 ), P=0.04 ]在 multivariate 线性 regression.CONCLUSIONOur 数据表演一重要日报在窝的 choroidal 厚度的变化,在 500 µ ;对窝和 1500 µ 鼻、时间的 m ; m 鼻音到窝。更厚的起始的 foveal choroidal 厚度并且是主导的眼睛可以影响 foveal choroidal 厚度的振幅。 | Mcng Zhao Xiu-Fcn Yang Xuan Jiao Apiradee Lim Xue-Tao Ren Torkel Snellingen Ning-Pu Liu | 2016 | International Journal of Ophthalmology(English edition)2016，9，4： | 2 |
| 12 | Reduced skeletal muscle inhibitor of κB β content is associated with insulin resistance in subjects with type 2 diabetes reversal by exercise training显示文摘 | Apiradee S Roberts CC Berria R | 2006 | Diabetes2006，55，3： | 1 |
| 13 | Serum hepatocyte growth factor and clinical outcome in biliary atresia显示文摘 | Paisarn Vejchapipat Apiradee Theamboonlers Rapeepan Chaokhonchai Voranush Chongsrisawat Soottiporn Chittmittrapap Yong Poovorawan | 2004 | Journal of Pediatric Surgery2004，，7： | 1 |
| 14 | Apolipopro- tein E gene and age -related macular degeneration in a Chinese population显示文摘 | Erdan Sun Apiradee Lim Xipu Liu | 2011 | Mol Vis2011，17，： | 1 |
| 15 | Effect of Acute Exercise on AMPK Signaling in Skeletal Muscle of Subjects With Type 2 Diabetes显示文摘 | Apiradee S Coletta DK Estela W | 2007 | Diabetes2007，56，： | 1 |
| 16 | Molecular analysis of hepatitis B virus associated with vaccine failure in infants and mothers: A case–control study in Thailand显示文摘 | Pattaratida Sa‐nguanmoo Pisit Tangkijvanich Piyanit Tharmaphornpilas Aim‐orn Rasdjarmrearnsook Saowanee Plianpanich Nutchanart Thawornsuk Apiradee Theamboonlers Yong Poovorawan | 2012 | J Med Virol2012，，8： | 1 |
| 17 | Comparative study of different methods to genotype hepatitis C virus type 6 variants显示文摘 | Teeraporn Chinchai Joost Labout Suwanna Noppornpanth Apiradee Theamboonlers Bart L Haagmans Albert D.M.E Osterhaus Yong Poovorawan | 2003 | Journal of Virological Methods2003，，2： | 1 |
| 18 | A case–control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma显示文摘 | Pisit Tangkijvanich Pattaratida Sa-nguanmoo Varocha Mahachai Apiradee Theamboonlers Yong Poovorawan | 2010 | Hepatology International2010，，3： | 1 |
| 19 | Seroprevalence and Genotype of Hepatitis C Virus among Immigrant Workers from Cambodia and Myanmar in Thailand显示文摘 | Akkarathamrongsin Srunthron Praianantathavorn Kesmanee Hacharoen Nisachol Theamboonlers Apiradee Tangkijvanich Pisit Poovorawan Yong | 2010 | Intervirology2010，，1： | 1 |
| 20 | Low pretreatment serum HBsAg level and viral mutations as predictors of response to PEG-interferon alpha-2b therapy in chronic hepatitis B显示文摘 | Pisit Tangkijvanich Piyawat Komolmit Varocha Mahachai Pattaratida Sa-nguanmoo Apiradee Theamboonlers Yong Poovorawan | 2009 | Journal of Clinical Virology2009，，2： | 1 |
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