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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Helicobacter pylori infection:How does age influence the inflammatory pattern?显示文摘The inflammatory pattern during Helicobacter pylori(H.pylori)infection is changeable and complex.During childhood,it is possible to observe a predominantly regulatory response,evidenced by high concentrations of key cytokines for the maintenance of Treg responses such as TGF-β1 and IL-10,in addition to high expression of the transcription factor FOXP3.On the other hand,there is a predominance of cytokines associated with the Th1 and Th17 responses among H.pylori-positive adults.In the last few years,the participation of the Th17 response in the gastric inflammation against H.pylori infection has been highlighted due to the high levels of TGF-β1 and IL-17 found in this infectious scenario,and growing evidence has supported a close relationship between this immune response profile and unfavorable outcomes related to the infection.Moreover,this cytokine profile might play a pivotal role in the effectiveness of anti-H.pylori vaccines.It is evident that age is one of the main factors influencing the gastric inflammatory pattern during the infection with H.pylori,and understanding the immune response against the bacterium can assist in the development of alternative prophylactic and therapeutic strategies against the infection as well as in the comprehension of the pathogenesis of the outcomes related to that microorganism. | Glauber Rocha Lima Araújo Hanna Santos Marques Maria Luísa Cordeiro Santos Filipe Antônio França daSilva Breno Bittencourt da Brito Gabriel Lima Correa Santos Fabrício Freire de Melo | 2022 | World Journal of Gastroenterology2022，28，4： | 2 |
| 3 | Nutritional parameters and mortality in incident hemodialysis patients显示文摘 | Araújo IC Kamimura MA Draibe SA | 2006 | Ren Nutr2006，16，1： | 1 |
| 4 | Incidence of diabetes mellitus in patients with lichen planus显示文摘 | Ara SA Rao BB | | 0，，01： | 1 |
| 5 | Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenesis agents显示文摘 | Holden SA Ara G | 1994 | Int J Cancer1994，57，： | 1 |
| 6 | Outcome of late anterior surgery and arthrodesis of lower cervical spinal cord injury 显示文摘 | Chowdhury SMNK Ahmed SU Ara SA | 2009 | Dhaka Med Coll2009，18，1： | 1 |
| 7 | Influence of all anti-angio-genic treatment on 9L gliosarcoma,oxygenation and response to cy-totoxic therapy显示文摘 | Teicher BA Holden SA Ara G | 1995 | Int J Cancer1995，61，5： | 1 |
| 8 | Potentiation of cytotoxic cancer therapies by TNP2470 alone and with other anti-angiogenic agents 显示文摘 | Teicher BA Holden SA Ara G | 1994 | Int J Cancer1994，57，6： | 1 |
| 9 | Nutritional parameters and mortality in incident hemodialysis patients显示文摘 | Araújo IC Kamimura MA Draibe SA | | 0，，01： | 1 |
| 10 | Influence of all anti - angio- genie treatment on 9L gliosareoma,oxygenation and response to ey- totoxic therapy显示文摘 | Teicher BA Holden SA Ara G | 1995 | Int 3 Cancer1995，6，5： | 1 |
| 11 | Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other antiangiogenic agents 显示文摘 | Teicher BA Holden Sa Ara C | 1994 | Int J Cancer1994，57，： | 1 |
| 12 | Oxidative stress biomarkers of exposure in the blood of cichlid species from a metal-contaminated river显示文摘 | Clarissa Bonafé Gaspar Ruas Cleoni dos Santos Carvalho Heloísa Sobreiro Selistre de Araújo Evaldo Luiz Gaeta Espíndola Marisa Narciso Fernandes | 2007 | Ecotoxicology and Environmental Safety2007，，1： | 1 |
| 13 | Characterization of waterborne polyurethane adhesives containing different amounts of ionic groups显示文摘 | Pe'rez-Limin~anaa M A Ara'n-Al'sa F Torro'-Palau A M | 2005 | Interuational Journal of Adhesion & Adhesives2005，25，： | 1 |
| 14 | The role arid regulation of cardiac angiotensin-converting enzyme for noninvasive molecular imaging in heart failure 显示文摘 | Aras O Messina SA Shirani J | 2007 | Curr Cardiol Rep2007，9，2： | 1 |
| 15 | Potentiation of cytotoxcic cancer therapies by TNP-470 alone and with other anti-angiogenic agents 显示文摘 | Teicher BA Holden SA Ara G | 1994 | Int J Cancer1994，57，6： | 1 |
| 16 | An update of Wallace's zoogeographic regions of the world显示文摘 | Holt BG Lessard J-P Borregaard MK Fritz SA Araújo MB Dimitrov D Fabre P-H Graham CH Graves GR Jφnsson KA Nogués-Bravo D Wang Z Whittaker RJ Fjelds(a) J Rahbek C | | 0，，： | 1 |
| 17 | Financial Analysis of Crop-Livestock-Forestry Systems in Goias,Brazil显示文摘Integration system is used to denote practices that combine systematic use of the land and technologies,in which forest species are used in conjunction with herbaceous plants and/or animals respecting a spatial or temporal arrangement.Knowing that this type of production seeks to balance ecological and economic factors,it is important to understand the financial benefits and risks involved in this production.Financial analysis,therefore,acts as an important analysis tool to foster this type of activity.The paper aimed to conduct analysis of investment risk of a crop-livestock-forestry system deployed in Brazil,comparing two different production scenarios,scenario I with 17 ha and scenario II with 25 ha.The risk analysis was performed using the Monte Carlo method and sensitivity analysis(by varying the factors:the discount rate,productivity and price).A cash flow was elaborated based on annual cost and revenues data of the agricultural crops(corn and soybeans),livestock and eucalyptus,using an interest rate of 6%per year.The results indicated that the optimal age for cutting the eucalyptus was at seven years on both scenarios;scenario I had better return on investment using deterministic and probabilistic methods;scenario I presents higher investments risks;there is a negative relation between discount rate and annualized net present value(ANPV);increased productivity of crops provides greater profitability to the system;there has been an increase in the economic viability of the system,as value has been added to the products.Monte Carlo method and the sensitivity analysis showed to be an appropriate tool to analyze the risk of crop-livestock-forestry systems,making it possible to foresee how the project will respond to possible scenarios. | Juliana Baldan Costa Neves Araújo Alvaro Nogueira de Souza Maísa Santos Joaquim Ilvan Medeiros Lustosa Junior Maisa Isabela Rodrigues Lucas Francisco de Dominicis | 2019 | Journal of Agricultural Science and Technology(B)2019，9，2： | 0 |
| 18 | Evolution of costs of cancer drugs in a Portuguese hospital显示文摘AIM:To analyze the costs of cancer drugs administered in a Portuguese Hospital compared with the Karolinska Institute study.METHODS:To evaluate spending on cancer drugs, we retrospectively analyzed data on the overall costs of cancer drugs, obtained at the Department of Medical Oncology of the Centro Hospitalar de Entre Douro e Vouga, between 2004 and 2010. In this comparative study we selected only drugs belonging to the following groups:chemotherapy, targeted therapy, immunotherapy and endocrine therapy. The selected drugs were further grouped according to their market placement year:≤ 1998, 1999 to 2002, 2003 to 2005, and 2006 to 2010. Drugs used as supportive therapy and bisphosphonates were excluded.RESULTS:The overall costs of cancer drugs increased gradually between 2004 and 2008(from €1911947 to €3666284), with an increase in the number of patients treated during this period. The expenditure decreased in 2009(€3438155) and increased again in 2010(€3673116), but the costs increment was not the same as in previous years. Chemotherapy and targeted therapy were responsible for most of the expenditure. Drugs placed on the national market before 1999 accounted for more than 50% of the expenditure up to 2007. From 2008, these drugs represented less than 50% of the total expenditure. Cancer drugs placed between 1999 and 2002 accounted for 25%-35% of the costs in all the years studied, while drugs placed between 2003 and 2005 accounted for less than 30%. Drugs placed between 2006 and 2010 were responsible for less than 10% of the expenditure.CONCLUSION:In this study, older drugs were responsible for most of the expenditure up to 2007, which is in agreement with the Karolinska study. | Vania Peixoto Ana Luísa Faria Márcia Gon?alves Joana Macedo Sónia Rego Emilio Macías Aldiro Magano Márcia Loureiro António Araújo | 2014 | World Journal of Clinical Oncology2014，5，2： | 0 |
| 19 | Influence of the COVID-19 pandemic in the gastrointestinal oncology setting:An overview显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has been impacting healthcare in various ways worldwide and cancer patients are greatly affected by the coronavirus disease 2019(COVID-19)pandemic.The reorganization of the health facilities in order to supply the high demand resulting from the aforementioned infection as well as the social isolation measures led to impairments for the diagnosis and follow-up of patients with gastrointestinal cancers,which has had an impact on the prognosis of the oncologic patients.In that context,health authorities and organizations have elaborated new guidelines with specific recommendations for the management of individuals with gastrointestinal neoplasms during the pandemic.Of note,oncologic populations seem to be more susceptible to unfavorable outcomes when exposed to SARS-CoV-2 infection and some interactions involving virus,tumor,host immune system and anticancer therapies are probably related to the poorer prognosis observed in those COVID-19 patients.Moreover,vaccination stands out as the main prevention method against severe SARS-CoV-2 infection and some particularities have been observed regarding the seroconversion of vaccinated oncologic patients including those with gastrointestinal malignancies.In this minireview,we gather updated information regarding the influence of the pandemic in the diagnosis of gastrointestinal neoplasms,new recommendations for the management of gastrointestinal cancer patients,the occurrence of SARSCoV-2 infection in those individuals and the scenario of the vaccination against the virus in that population. | Breno Bittencourt de Brito Hanna Santos Marques Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Glauber Rocha Lima Araújo Lara de Araujo Valente Fabrício Freire de Melo | 2022 | World Journal of Gastrointestinal Pathophysiology2022，13，5： | 0 |
| 20 | Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern worldwide.In that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and remedy.AIM To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease outcomes.METHODS This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian hospital.RESULTS The patients had a median age of 65.60±15.78 years.Dyspnea was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the patients.At least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with death.Nausea and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective factor.CONCLUSION This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected individuals.The associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features. | Fillipe Dantas Pinheiro Luana Weber Lopes Rafael Santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito Maria Luísa Cordeiro Santos Geovani Moreno Santos Júnior Maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo | 2023 | World Journal of Clinical Cases2023，11，8： | 0 |
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