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| 1 | High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data显示文摘BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the liver.Data on hepatic histopathological findings in COVID-19 is scarce.AIM To characterize hepatic pathological findings in patients with COVID-19.METHODS We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA guidelines.Eligible trials were those including patients of any age and COVID-19 diagnosis based on a molecular test.Histopathological reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were reviewed.Articles including less than ten patients were excluded.Proportions were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,respectively.RESULTS We identified 18 studies from 7 countries;all were case reports and case series from autopsies.All the patients were over 15 years old,and 67.2%were male.We performed a meta-analysis of 5 studies,including 116 patients.Pooled prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and necrosis.CONCLUSION We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver features.Other frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or proliferation.Further studies are needed to establish the mechanisms and implications of these findings. | Luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise Juan Pablo Arab | 2020 | World Journal of Gastroenterology2020，26，48： | 3 |
| 2 | Flavonoids and hearthealth:Proceeding of the ILSI north America flavonoids workshop显示文摘 | Erdman-Jw Jr Balentine D Arab L | 2007 | J Nutr2007，137，： | 1 |
| 3 | The Epidemiology of tea consumption and colorectal cancer incidence显示文摘 | Arab L II' yasova D | 2003 | J Nutr2003，133，： | 1 |
| 4 | Coronary artery perforation during percutaneous coronary intervention: incidence and outcomes in the new interventional era 显示文摘 | Ramana RK Arab D Joyal D | 2005 | J Invas Cardiol2005，17，： | 1 |
| 5 | Green and black tea consumption and risk of stroke : A meta-analysis显示文摘 | Arab L Liu W Elashoff D | 2009 | Stroke2009，40，5： | 1 |
| 6 | Cardiovascular manifestations of acute intrscranial lesions:pathophysiology, manifestations, and treatment显示文摘 | Arab D Yahia AM Qureshi AI | 2003 | J Intensive Care Med2003，18，3： | 1 |
| 7 | Coronary artery perforation during percutaneous coronary intervention:incidence and outcomes in the new interventional era显示文摘 | Ramana RK Arab D Joyal D | 2005 | J Invas Cardiol2005，17，： | 1 |
| 8 | The prognostic value of the neutrophil-lymphocyte ratio ( NLR ) in acute pancreatitis: identification of an optimal NLR显示文摘 | Suppiah A Malde D Arab T | 2013 | Gastrointest Surg2013，17，4： | 1 |
| 9 | Coronary artery perforaintion during periutaneous coronary intervention;incidence and outcomes in the new interventional era显示文摘 | Ramana RK Arab D Joal D | 2005 | J Invasive Cordior2005，17，11： | 1 |
| 10 | Huge malignant solitary fibrous tumor of the pleura 显示文摘 | ARAB WA LAMOTH D ECHAV V | 2012 | Cen Thorac Cardiovasc Surg2012，60，6： | 1 |
| 11 | The prognostic value of the neutrophil-lymphocyte ratio (NLR) in acute pancreatitis:identification of an optimal NLR显示文摘 | Suppiah A Malde D Arab T | 2013 | J Gastrointest Surg2013，17，4： | 1 |
| 12 | Software-Based Resolver-to-Digital Converter for DSP-Based Drives Using an Improved Angle-Tracking Observer 显示文摘 | Arab Khaburi D | 2012 | IEEE Transactions on Industrial Electronics2012，61，4： | 1 |
| 13 | Coronary artery perforation during percutaneous coronary intervention:incidence and outcomes in the new interventional era显示文摘 | Ramana RK Arab D Joyal D | | 0，，： | 1 |
| 14 | 显示文摘 | Zienlddiny S Ryberg D Arab MO | 2001 | Br J Cancer2001，84，3： | 1 |
| 15 | Mosaieism for a small marker chromosome resulting from a familiar Robertsonian translocation(21 ;22) 显示文摘 | Arab S Chitayat D Gardner H A | 1999 | Clin Genet1999，56，2： | 1 |
| 16 | Software-based resolver-to-digital converter for DSP-based drives using an improved angle-tracking observer 显示文摘 | Arab K D | 2012 | IEEE Transactions on Industrial Electronics2012，61，4： | 1 |
| 17 | Antiplatelet therapy in anticoagulated patients requiring coronary intervention 显示文摘 | Arab D Lewis B Cho L | 2005 | J Invasive Cardiol2005，17，： | 1 |
| 18 | The efficacy of brain natriuretic peptide levels in differentiating constrictive pericarditis from restrictive cardiomyopathy显示文摘 | Leya F Arab D Joyal D | 2005 | J Am Coll Cardiol2005，45，11： | 1 |
| 19 | Coronary artery perforation during percutaneous coronary intervention:incidence and outcomes in the new interventional era显示文摘 | Ronana RK Arab D Joyal D | 2005 | J Invas Cardiol2005，17，11： | 1 |
| 20 | The use of phospho-lipids fatty acids (PLFA) in the determination of rhizosphere specific microbial communities of two wheat cultivars显示文摘 | Arab H G D E Vlich V Sikora R A | 2001 | Plant &Soil2001，228，： | 1 |
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