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您的检索式：作者名="Archi Gupta"
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| 1 | Skin as an immune organ and the site of biomimetic,non-invasive vaccination显示文摘A vaccine must be sufficiently stable and cause no discernible discomfort or organ damage both during administration and at the injection site. To achieve these aims, the skin offers a viable platform, provided, antigens mustpenetrate the skin barrier and then exit the skin through deformable yet stable vesicular carriers to enter thelymphatic system. Even after such antigen delivery into the body, the intended immune response can only beattained if the following immune response has previously been correctly understood at the cellular and molecularlevels. Here we review, the underlying immunological decision tree that has several branching points to generatean optimal immune response. The tolerance versus immunity decision during and after the delivery of an antigen viaskin depends on i) antigen/pathogen application effects on the cutaneous microenvironment, ii) the variousinvolved cells type (skin resident cells or directly the lymph node resident cells), and regulatory molecules. Theskin microenvironment alters due to skin perturbation. The skin is perturbed directly by the antigens/pathogenswhich activate the release of mediators and cytokines and thus trigger an autocrine and paracrine effect, or,indirectly via the antigen/pathogen influence on the commensal microorganisms on the skin (which helpmaintain skin homeostasis). The skin microenvironment changes by the mode of antigen delivery.The cue from cutaneous immunology in vaccine delivery across intact skin may provide insight for future noninvasive vaccination suggesting a possible shift in the vaccination protocols and the essential paradigmrefinement. | Amla Chopra Archi Gupta | 2022 | Medicine in Novel Technology and Devices2022，，4： | 0 |
| 2 | Empirical assessment of adaptation to climate change impacts of mountain households:development and application of an Adaptation Capability Index显示文摘The present study proposes an index to assess the potential for adaptation to climate change for households in the mountainous regions. The index provides a realistic approach to recognize social and natural factors which contribute to successful adaptation and addresses several household functions,such as social networking, livelihood strategy, adjustment strategies, resource availability and accessibility. The proposed Adaptation Capability Index(ACI) is analytically defined, mathematically formulated and field tested on mountainous households in urban and semi-urban regions of the Uttarakhand Himalaya in India. To gather data on the topic relevant to the ACI, a household scale questionnaire was developed and administered to 120 heads of households through face-to-face interviews. The results highlight higher adaptive capability of urban households and low adaptation capacity of rural households due to poor farm productivity, low accessibility and availability of resources and technological input. Future programs and policies must include and implement regulations to remedy attributive factors responsible for higher adaptation. This paper may be applicable to other mountainous regions and may provide insights for effective adaptation strategies to climate change. | Rajiv PANDEY Nandini MAITHANI Roberta ARETANO Giovanni ZURLINI Kelli M ARCHIE Ajay K GUPTA Vishnu Prasad PANDEY | 2016 | Journal of Mountain Science2016，13，8： | 0 |
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