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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | Cytotoxic effects of the novel isoflavone, phenoxodiol, on prostate cancer cell lines显示文摘 | Simon Mahoney Frank Arfuso Pierra Rogers Susan Hisheh David Brown Michael Millward Arun Dharmarajan | 2012 | Journal of Biosciences2012，，1： | 1 |
| 3 | Targeting tran- scription factor STAT3 for cancer prevention and therapy 显示文摘 | CHAI EZ SHANMUGAM MK ARFUSO F | 2016 | Phar- macol Ther2016，162，： | 1 |
| 4 | Cytotoxic effects of the no- vel isoflavone, phenoxodiol, on prostate cancer cell lines 显示文摘 | Mahoney S Arfuso F Rogers p | 2012 | J Bio- sci2012，37，1： | 1 |
| 5 | The role of the cysteine -rich domain and netrin- like domain of secreted frizzled- related protein 4 in angiogenesis inhibition in vitro显示文摘 | Longman D Arfuso F Viola HM | 2012 | Oncol Res2012，20，1： | 1 |
| 6 | Targeting TNF-related apoptosis-inducing ligand(TRAIL)receptor by natural products as a potential therapeutic approach for cancer therapy显示文摘 | DAI X ZHANG J ARFUSO F | 2015 | Exp Biol Med(Maywood)2015，240，6： | 1 |
| 7 | Rare-earth-activated glass-ceramic wave guides显示文摘 | S.Berneschi S.Soria G.C.Righini G.Alombert-Goget A.Chiappini A.Chiasera Y.Jestin M.Ferrari S.Guddala E.Moser S.N.B.Bhaktha B.Boulard C.Duverger Arfuso and S.Turrell | | 0，，： | 1 |
| 8 | Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy显示文摘 | Dai X Zhang J Arfuso F | 2015 | Exp Biol Med (Maywood)2015，240，6： | 1 |
| 9 | Bioactive lipids in cancer stem cells显示文摘Tumours are known to be a heterogeneous group of cells,which is why they are difficult to eradicate.One possible cause for this is the existence of slow-cycling cancer stem cells(CSCs)endowed with stem cell-like properties of self-renewal,which are responsible for resistance to chemotherapy and radiotherapy.In recent years,the role of lipid metabolism has garnered increasing attention in cancer.Specifically,the key roles of enzymes such as stearoyl-CoA desaturase-1 and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in CSCs,have gained particular interest.However,despite accumulating evidence on the role of proteins in controlling lipid metabolism,very little is known about the specific role played by lipid products in CSCs.This review highlights recent findings on the role of lipid metabolism in CSCs,focusing on the specific mechanism by which bioactive lipids regulate the fate of CSCs and their involvement in signal transduction pathways. | Romana-Rea Begicevic Frank Arfuso Marco Falasca | 2019 | World Journal of Stem Cells2019，11，9： | 0 |
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