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| 1 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 2 | Factors associated with surgery in patients with intra-abdominal fistulizing Crohn's disease显示文摘AIM To characterize radiological and clinical factors associated with subsequent surgical intervention in Crohn's disease(CD) patients with intra-abdominal fistulae.METHODS From a cohort of 1244 CD patients seen over an eight year period(2006 to 2014), 126 patients were identified as having intra-abdominal fistulae, and included in the study. Baseline patient information was collected from the medical records. Imaging studies were assessed for: anatomic type and number of fistulae; diameter of the inflammatory conglomerate; length of diseased bowel; presence of a stricture with pre-stenotic dilatation; presence of an abscess; lymphadenopathy; and the degree of bowel enhancement. Multivariate analysis for the prediction of abdominal surgery was calculated via Generalized Linear Models.RESULTS In total, there were 193 fistulae in 132 patients, the majority(52%) being entero-enteric. Fifty-nine(47%) patients underwent surgery within one year of the imaging study, of which 36(29%) underwent surgery within one month. Radiologic features that were associated with subsequent surgery included: multiple fistulae(P = 0.009), presence of stricture(P = 0.02), and an entero-vesical fistula(P = 0.01). Evidence of an abscess, lymphadenopathy, or intense bowel enhancement as well as C-reactive protein levels was not associated with an increased rate of surgery. Patients who were treated after the imaging study with combination immunomodulatory and anti-TNF therapy had significantly lower rates of surgery(P = 0.01). In the multivariate analysis, presence of a stricture [RR 4.5(1.23-16.3), P = 0.02] was the only factor that increased surgery rate.CONCLUSION A bowel stricture is the only factor predicting an increased rate of surgery. Radiological parameters may guide in selecting treatment options in patients with fistulizing CD. | Shaul Yaari Ariel Benson Eyal Aviran Naama Lev Cohain Ran Oren Jacob Sosna Eran Israeli | 2016 | World Journal of Gastroenterology2016，22，47： | 1 |
| 3 | 评价与开发地质碳储存造成的地下水含水层中CO2泄漏的修复方案显示文摘人们有充分的理由相信,适当选择和实施二氧化碳(CO2)储存项目具有长期安全性。然而,CO2从地层泄漏的可能性依然存在,例如,在废弃井中注入的C02有可能泄漏进入上覆地下含水层。在CO2泄漏事件中,操作者应谨慎、快速地进行补救措施。迄今为止,CO2泄漏修复计划侧重于使用泄漏井的封堵方法。在某些情况下,也可能需要圈闭或去除含水层中泄漏的CO2。鉴于保护饮用水资源和满足相关许可证要求的重要性,本项研究对一系列假定泄漏情况的多种修复方案进行了分析。本文考虑了3种特定修复目标,即降低含水层中可移动CO2数量、降低含水层中CO2总量以及降低液相CO2浓度。首先,利用多相流模拟器TOUGH2评估控制地下水含水层中泄漏的CO2范围和形状的过程与参数;其次,通过系统模拟来鉴定控制CO2提取的多相流动过程与相特性,例如浮力诱导流、毛细管捕集以及CO2溶解和离溶作用。随后,对比了不同修复方案的效果,包括:(1)通过垂直和水平抽水井去除气相和液相CO2;(2)注入水以溶解气相CO2并增大毛细管捕集力;(3)结合多井注入与提取方案。基于本项研究结果,可以得出多种有关不同修复方案效果的结论。首先,如有必要,通过固定和/或提取可有效修复地下水含水层中泄漏的CO2;其次,对于未形成重力舌区域内的小范围CO2羽而言,通过处于CO2羽中部的单独垂直井在数年内可去除所有CO2。在形成大范围重力舌的情况下(在盖层下圈闭的薄层、大范围CO2羽),去除CO2羽水平井更加有效,虽然这可能需要10年或更长时间。实际上,在这些情况下,注入水并快速固定和溶解CO2羽可在短期内生成更有效的圈闭。但最有效修复大范围CO2羽的方案包括结合连续和/或同时多井注入和抽取。在这种情况下,能够有效圈闭和修复大范围的CO2羽,所用时间取决于井的数量、位置及流速。 | Ariel Esposito Sally M. Benson 赵玉军(翻译) 葛秀珍(校对) | 2012 | 水文地质工程地质技术方法动态2012，，5： | 0 |
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