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| 1 | In vitro cytocompatibility evaluation of poly(octamethylene citrate) monomers toward their use in orthopedic regenerative engineering显示文摘Citrate based polymer poly(octamethylene citrate)(POC)has shown promise when formulated into composite material containing up to 65 wt%hydroxylapatite(HA)for orthopedic applications.Despite significant research into POC,insufficient information about the biocompatibility of the monomers 1,8-Octanediol and Citrate used in its synthesis is available.Herein,we investigated the acute cytotoxicity,immune response,and long-term functionality of both monomers.Our results showed a cell-type dependent cytotoxicity of the two monomers:1,8-Octanediol induced less acute toxicity to 3T3 fibroblasts than Citrate while presenting comparable cytotoxicity to MG63 osteoblast-like cells;however,Citrate demonstrated enhanced compatibility with hMSCs compared to 1,8-Octanediol.The critical cytotoxic concentration values EC30 and EC50,standard for comparing cytotoxicity of chemicals,were also provided.Additionally,Citrate showed slower and less inhibitory effects on long-term hMSC cell proliferation compared with 1,8-Octanediol.Furthermore,osteogenic differentiation of hMSCs exposure to Citrate resulted in less inhibitory effect on alkaline phosphatase(ALP)production.Neither monomer triggered undesired pro-inflammatory responses.In combination with diffusion model analysis of monomer release from cylindrical implants,based on which the maximum concentration of monomers in contact with bone tissue was estimated to be 2.2104 mmol/L,far lower than the critical cytotoxic concentrations as well as the 1,8-Octanediol concentration(0.4 mg/mL or 2.7 mmol/L)affecting hMSCs differentiation,we provide strong evidence for the cytocompatibility of the two monomers degraded from citrate-based composites in the orthopedic setting. | Chuying Ma Ethan Gerhard Qiaoling Lin Silun Xia April Dawn Armstrong Jian Yang | 2018 | Bioactive Materials2018，3，1： | 2 |
| 2 | Cytokine balance and inmmunosuppressive change at cardiac surgery 显示文摘 | Mcbride WT Armstrong MA | 1995 | Br J Anesth1995，75，： | 1 |
| 3 | Microtensile bond strength of self-etching adhesives to ground and unground enamel显示文摘 | Ibarra G Vargas MA Armstrong SR | 2002 | J Adhes Dent2002，4，2： | 1 |
| 4 | Wine, liquor, beer, and mortality 显示文摘 | Klatsky AL Friedman GD Armstrong MA | 2003 | Am J Epidemiol2003，158，6： | 1 |
| 5 | Circles of care : develop- ment and initial evaluation of a peer support model for African Ameri- cans with advanced cancer 显示文摘 | Hanson LC Armstrong TD Green MA | 2013 | Health Educ B ehav2013，40，5： | 1 |
| 6 | Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 Diabetes显示文摘 | Green JB Bethel MA Armstrong PW | 2015 | N Engl J Med2015，373，3： | 1 |
| 7 | Multicore myopathy, microcephaly, aganglionosis, and short stature 显示文摘 | Kim JJ Armstrong DD Fishman MA | 1994 | J Child Neurol1994，9，3： | 1 |
| 8 | The choice of anesthetic maintenancetechnique influences the antiinflammatory cytokine response to abdominal suryery 显示文摘 | Gilliland HE Armstrong MA Garabine U | 1997 | Anesth Analy1997，85，： | 1 |
| 9 | ACC/AHA guidelines for the martagement of patients with ST-elevation myocardial infarction-executive summary:port of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of patients with Acute Myocardial Infarction) 显示文摘 | Antman EM Anbe DT Armstrong PW Bates ER Green LA Hand M Hochman JS Krumholz HM Kushner FG Lamas GA Mullany CJ Ornato JP pearle DL Sloan MA Smith SCJr Alpert JS Anderson JL Faxon DP Fuster V Gibbons RJ Gregoratos G Halperin JL Hiratzka LF Hunt SA Jacobs AK American College of Cardiology American Heart Association Task Force on Practice Guidelines | 2004 | Circulation2004，110，5： | 1 |
| 10 | Immunomodulation: an important concept in modern anaesthesia显示文摘 | McBride WT Armstrong MA McBride SJ | 1996 | Anaesthesia1996，51，： | 1 |
| 11 | Immunomodulation: an important concept inmodern anaesthesia 显示文摘 | Mcbride WT Armstrong MA Mcbride SJ | 1996 | Anaesthesia1996，51，： | 1 |
| 12 | Alcohol and Mortaiity显示文摘 | Arthur L Armstrong MA Gary D | 1992 | AnnIntern Med1992，117，8： | 1 |
| 13 | The choice of anestheticmaintenance technique influences the antiinflammatory cytokine re-sponse to abdominal surgery显示文摘 | Gilliland HE Armstrong MA Carabine U ef al | 1997 | Anesth Analg1997，85，6： | 1 |
| 14 | Sex-specific associa- tions between placental leptin promoter DNA methylation and in- fant neurobehavior显示文摘 | Lesseur C Armstrong DA Murphy MA | 2014 | Psychoneuroendocrinology2014，40，： | 1 |
| 15 | Mesenchymal stem ceils in immuno- regulation 显示文摘 | Chen X Armstrong MA Li G | 2006 | Immunol C ell Biol2006，84，5： | 1 |
| 16 | Microtensilc bond strength of a total-etch 3-step, total-etch 2-step, self-etch 2- step, and a self etch 1-step dentin bonding system through 15- month water storage 显示文摘 | Armstrong SR Vargas MA Fang Q | 2003 | J Adhes Dent2003，5，1： | 1 |
| 17 | Reduced production of interleukin 12 by interferon gamma primed alveolar macrophages from atopic asthmatic subjects显示文摘 | Plummeridge MJ Armstrong L Birchall MA | 2000 | Thorax2000，55，10： | 1 |
| 18 | Mesenchymal stem cells in immunoregulation显示文摘 | Chen X Armstrong MA Li G | | 0，，05： | 1 |
| 19 | Immunomodulation:an important concept in modem anaesthesia显示文摘 | McBride WT Armstrong MA McBride SJ | | 0，，05： | 1 |
| 20 | Plasma and urinary eytokine homeostasis and renal function during cardiac surgery without eardiopulmonary bypass 显示文摘 | Gorrnley SM McBride WT Armstrong MA | 2002 | Cytokine2002，17，2： | 1 |
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