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| 1 | Treatment of early gastric cancer in the Western World显示文摘The incidence rate of gastric cancer is much higher in Asia than in the Western industrial nations.According to the different screening programs in Japan and Korea about fifty percent of treated patients had an early tumor stage.In contrast,European and American patients with gastric cancer had an advanced tumor stage.Therefore,the experience for the various therapeutic options for gastric cancer may be different between these regions.In this review we tried to point out the treatment modalities in Western industrial countries for early gastric cancer. | Elfriede Bollschweiler Felix Berlth Christoph Baltin Stefan Mnig Arnulf H Hlscher | 2014 | World Journal of Gastroenterology2014，20，19： | 8 |
| 2 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 3 | Altered levels of the onco-microRNA 21 and the tumor-supressor microRNAs143 and 145 in advanced rectal cancer indicate successful neoadjuvant chemoradiotherapy显示文摘 | Uta Drebber Max Lay Inga Wedemeyer Daniel Vallb?hmer Elfriede Bollschweiler Jan Brabender Stefan M?nig Arnulf H?lscher Hans Dienes Margarete Odenthal | 2011 | International Journal of Oncology2011，，： | 2 |
| 4 | High response rates to pomalidomide and dexamethasone in patients with refractory myeloma,final analysis of IFM 2009-02显示文摘 | Leleu X Attal M Arnulf B | | 0，，： | 1 |
| 5 | Nasa natural killer lymphoma associated with Epstein-Barr virus in a patient infected with human immunodeficiency virus显示文摘 | CANIONI D ARNULF B ASSO-BONNET M | 2001 | Arch Pathol Lab Med2001，125，： | 1 |
| 6 | Iron deficiency in children with attention-deficit/hyperactivity disorder 显示文摘 | Konofal E Lecendreux M Arnulf I | 2004 | Arch Pediatr Adolesc Med2004，158，12： | 1 |
| 7 | Psrkinson's disease and sleepiness:an integral part of PD显示文摘 | Arnulf I Konofal E Merino-Andreu M | 2002 | Neurology2002，58，： | 1 |
| 8 | Pomalidomide plus low-dose dexamethasone is active and well tolerated in bortezomib and lenalidomide refractory multiple myeloma:Intergroupe Francophone du My61ome 2009-02显示文摘 | LELEU X ATTAL M ARNULF B Et al | 2013 | Blood2013，121，11： | 1 |
| 9 | Pomalidomide pluslow-dose dexamethasone is active and well tolerated inbortezomib and lenalidomide-refractory multiple myeloma:Intergroupe Francophone du Myelome 2009-02显示文摘 | LELEU X ATTAL M ARNULF B | 2013 | Blood2013，121，11： | 1 |
| 10 | A combined system of lagoon and constructed wetland for an effective wastewater treatment显示文摘 | ChristianR S Sabine W Arnulf M | 2003 | Water Research2003，37，9： | 1 |
| 11 | Lymph node staging of esophageal squamous cell carcinoma in patients with and without neoadjuvant radiochemotherapy: Histomorphologic analysis显示文摘 | Wolfgang Schr?der M.D. Stephan E. Baldus M.D. Stefan P. M?nig M.D. Tobias K. E. Beckurts M.D. Hans P. Dienes M.D. Arnulf H. H?lscher M.D | 2002 | World Journal of Surgery2002，，5： | 1 |
| 12 | Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement显示文摘AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and 2006.One hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were examined.Survival of the patients was analyzed according to intra-and extra-capsular LNI.RESULTS:Five-year survival rate was 22.5% for the entire patient population.Patients with extracapsular LNI had a 5-year survival rate of 16.7%,which was comparable to the 15.8% in patients with infiltrated nodes of the celiac trunk(pM1lymph).In contrast to patients treated with surgery alone,neoadjuvant therapy resulted in signif icantly(P = 0.001) more patients with pN0/M0(51.6% vs 25.0%).In 17.6% of the patients with surgery alone vs 16.8% with neoadjuvant CRT,extracapsular LNI was detected.Neoadjuvant therapy does not reduce the occurrence of extracapsular LNI.CONCLUSION:Extracapsular LNI is an independent negative prognostic factor not influenced by neoadjuvant CRT.In a revised staging system for esophageal cancer,extracapsular LNI should be considered. | Ralf Metzger Elfriede Bollschweiler Uta Drebber Stefan P Mnig Wolfgang Schrder Hakan Alakus Martin Kocher Stephan E Baldus Arnulf H Hlscher | 2010 | World Journal of Gastroenterology2010，16，16： | 1 |
| 13 | The overexpression of c-met as a prognostic indicator for gastric carcinomacompared to p53 and p21 nuclear accumulation显示文摘 | Uta Drebber Stephan Baldus Britt Nolden Guido Grass Elfriede Bollschweiler Hans Dienes Arnulf H?lscher Stefan M?nig | 2008 | Oncology Reports2008，，6： | 1 |
| 14 | Parkinson' s disease and sleepiness: an integral part of PD显示文摘 | Arnulf I Konofal E Merino-Andreu M | 2002 | Neurology2002，58，： | 1 |
| 15 | Dissimilatory Oxidation and Reduction of Elemental Sulfur in Thermophilic Archaea显示文摘 | Arnulf Kletzin Tim Urich Fabian Müller Tiago M. Bandeiras Cláudio M. Gomes | 2004 | Journal of Bioenergetics and Biomembranes2004，，1： | 1 |
| 16 | A combined system of lagoon and constructed wetland for an effective wastewater treatment 显示文摘 | Christian R S Sabine W Arnulf M | 2003 | Water Res2003，37，9： | 1 |
| 17 | Iron deficiency children with attention deficit/hyperactivity disorder显示文摘 | Lecendreux M Arnulf I | 2004 | Arch Pediatr A dolesc Med2004，158，12： | 1 |
| 18 | Iron deficiency in children with attention-deficit/hyperactivity Disorder 显示文摘 | Konofal E Lecendreux M Arnulf I | 2004 | Arch Pediatr Adolesc Med2004，158，12： | 1 |
| 19 | Effects of venous com- pression ofthe legs on overnight rostral fluid shift and ob- structive sleep apnea显示文摘 | Redolfi S Arnulf I Pottier M | 2011 | Respir Physiol Neurobiol2011，175，3： | 1 |
| 20 | Early Gastric Cancer: Lymph Node Metastasis Starts With Deep Mucosal Infiltration显示文摘 | Arnulf H. H?lscher Uta Drebber Stefan P. M?nig Christian Schulte Daniel Vallb?hmer Elfriede Bollschweiler | 2009 | Annals of Surgery2009，，5： | 1 |
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