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| 1 | Association of the GNAS1 T393C polymorphism with tumor stage and survival in gastric cancer显示文摘AIM:To analyze the impact of the GNAS1 T393C polymorphism on prognosis and histopathology of gastric cancer.METHODS:Genomic DNA was extracted from paraffinembedded tissues of 122 patients with primary gastric carcinoma and from the blood of 820 healthy white individuals.Allelic discrimination was performed by quantitative real-time polymerase chain reaction.Genotyping was correlated with histopathologic parameters and with overall survival according to the Kaplan-Meier approach and with multivariate analysis by multiple stepwise regression.RESULTS:Thirty-nine(32%) patients displayed a CC genotype,57(46.7%) a CT genotype and 26(21.3%) a TT genotype.The frequency of the C allele(fC) in the patient group was 0.55,which was not signif icantly different from that of healthy blood donors.The distribution was compatible with the Hardy-Weinberg equilibrium.Analysis of clinicopathological parameters did not show any signif icant correlation of the T393C genotype with gender(P=0.50),differentiation(P=0.29),pT-category(P=0.19),pN-category(P=0.30),pM-category(P=0.25),R-category(P=0.95),the classifications according to WHO(P=0.34),Laurén(P=0.16),Goseki(P=1.00) and Ming(P=0.74).Dichotomization between C+(CC+CT) and C-genotypes(TT),however,revealed signif icantly more advanced tumor stages(P=0.023) and lower survival rates(P=0.043) for C allele carriers.CONCLUSION:The present study provides strong evidence to suggest that the GNAS1 T393C allele carrier status influences tumor progression and survival in gastric cancer with higher tumor stages and a worse outcome for C allele carriers. | Hakan Alakus Stefan P Mnig Ute Warnecke-Eberz Gül Alakus Günther Winde Uta Drebber Klaus J Schmitz Kurt W Schmid Kathrin Riemann Winfried Siffert Elfriede Bollschweiler Arnulf H Hlscher Ralf Metzger | 2009 | World Journal of Gastroenterology2009，15，48： | 3 |
| 2 | Deep brain stimulation in Parkinson's disease:opposite effects of stimulation in the pallidum 显示文摘 | Bejjani P Damier B Arnulf P | 1998 | Mov Disord1998，13，： | 1 |
| 3 | Neoadjuvant chemoradiotherapy for esophageal cancer:Impact on extracapsular lymph node involvement显示文摘AIM:To assess the effects of neoadjuvant chemoradiotherapy(CRT) on the presence of extracapsular lymph node involvement(LNI) and its prognostic value in patients with resected esophageal cancer.METHODS:Two hundred and ninety-eight patients with advanced esophageal cancer underwent esophagectomy between 1997 and 2006.One hundred and ninety patients(63.8%) were treated with neoadjuvant CRT prior to resection.A total of 986 metastatic LNs were examined.Survival of the patients was analyzed according to intra-and extra-capsular LNI.RESULTS:Five-year survival rate was 22.5% for the entire patient population.Patients with extracapsular LNI had a 5-year survival rate of 16.7%,which was comparable to the 15.8% in patients with infiltrated nodes of the celiac trunk(pM1lymph).In contrast to patients treated with surgery alone,neoadjuvant therapy resulted in signif icantly(P = 0.001) more patients with pN0/M0(51.6% vs 25.0%).In 17.6% of the patients with surgery alone vs 16.8% with neoadjuvant CRT,extracapsular LNI was detected.Neoadjuvant therapy does not reduce the occurrence of extracapsular LNI.CONCLUSION:Extracapsular LNI is an independent negative prognostic factor not influenced by neoadjuvant CRT.In a revised staging system for esophageal cancer,extracapsular LNI should be considered. | Ralf Metzger Elfriede Bollschweiler Uta Drebber Stefan P Mnig Wolfgang Schrder Hakan Alakus Martin Kocher Stephan E Baldus Arnulf H Hlscher | 2010 | World Journal of Gastroenterology2010，16，16： | 1 |
| 4 | Hallucinations,REM sleep,and Parkinson's disease:a medical hypothesis显示文摘 | Arnulf I Bonnet AM Damier P | 2000 | Neurology2000，55，： | 1 |
| 5 | Halhlcinations, REM sleep, and Parkinson's disease A medical hypothesis显示文摘 | Arnulf I Bonnet A M Damier P | 2000 | Neurology2000，55，2： | 1 |
| 6 | Kleine-Levin syndrome : state :ft the art 显示文摘 | Arnulf I Lecendreux M Franco P | 2008 | Rev Neurol ( Pails )2008，164，89： | 1 |
| 7 | Asphalt-aggregate Interactions Characterized by Zeta Potential and Re- tained Strength Measurements for Natural and Organosilane-treated Aggregates显示文摘 | Arnulf P Hagen William D Lee Tisha M Jones | 1996 | Journal of the Transportation Re- search Board1996，1535，： | 1 |
| 8 | 查看详情显示文摘 | Rousslot P Larghero J Arnulf B Poupon J. Royer B. Tibi A. Madelain e C.I. Cimerman P. Chevret S. Domb ret O.H. Claude B.J.and Paul F.J | | 0，，： | 1 |
| 9 | A clinical and pharmacological study of arsenic trioxide in advanced multiple myeloma patients显示文摘 | Rousselot P Larghero J Arnulf B | 2004 | Leukemia2004，18，9： | 1 |
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