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| 1 | Assessment of neovascularization within carotid plaques in patients with ischemic stroke显示文摘AIM:To assess neovascularization within human ca-rotid atherosclerotic soft plaques in patients with isch-emic stroke.METHODS:Eighty-one patients with ischemic stroke and 95 patients without stroke who had soft athero-sclerotic plaques in the internal carotid artery were studied.The thickest soft plaque in each patient was examined using contrast-enhanced ultrasound.Time-intensity curves were collected from 5 s to 3 min after contrast injection.The neovascularization within the plaques in the internal carotid artery was evaluated using the ACQ software built into the scanner by 2 of the experienced investigators who were blinded to the clinical history of the patients.RESULTS:Ischemic stroke was present in 7 of 33 patients(21%) with grade Ⅰ plaque,in 14 of 51 pa-tients(28%) with grade Ⅱ plaque,in 26 of 43 patients(61%) with grade Ⅲ plaque,and in 34 of 49 patients(69%) with grade Ⅳ plaque(P < 0.001 comparing grade Ⅳ plaque with grade I plaque and with grade Ⅱ plaque and P = 0.001 comparing grade Ⅲ plaque with grade Ⅰ plaque and with grade Ⅱ plaque).Analysis of the time intensity curves revealed that patients with ischemic stroke had a significantly higher intensity of enhancement(IE) than those without ischemic stroke(P < 0.01).The wash-in time(WT) of plaque was signifi-cantly shorter in stroke patients(P < 0.05).The sensi-tivity and specificity for IE in the plaque were 82% and 80%,respectively,and for WT were 68% and 74%,respectively.There was no significant difference in the peak intensity or time to peak between the 2 groups.CONCLUSION:This study shows that the higher the grade of plaque enhancement,the higher the risk of ischemic stroke.The data suggest that the presence of neovascularization is a marker for unstable plaque. | Wilbert S Aronow Chandra K Nair David Cosgrove | 2010 | World Journal of Cardiology2010，2，4： | 29 |
| 2 | The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor显示文摘 | Anne E. Powell Yang Wang Yina Li Emily J. Poulin Anna L. Means Mary K. Washington James N. Higginbotham Alwin Juchheim Nripesh Prasad Shawn E. Levy Yan Guo Yu Shyr Bruce J. Aronow Kevin M. Haigis Jeffrey L. Franklin Robert J. Coffey | 2012 | Cell2012，，1： | 2 |
| 3 | Effects of Digoxin on Morbidity and Mortality in Diastolic Heart Failure: The Ancillary Digitalis Investigation Group Trial显示文摘 | Ali Ahmed Michael W. Rich Jerome L. Fleg Michael R. Zile James B. Young Dalane W. Kitzman Thomas E. Love Wilbert S. Aronow Kirkwood F. Adams Mihai Gheorghiade | 2006 | Circulation2006，，5： | 2 |
| 4 | Cardiac papillary fibroelastoma:The need for a timely diagnosis显示文摘Cardiac papillary fibroelastomas(CPFs) are the second most common primary cardiac tumors and the most common cardiac valvular tumors. Although they are histologically benign and usually asymptomatic, CPFs can lead to serious and life-threatening complications like myocardial infarction, stroke, pulmonary embolus, cardiac arrest etc. CPFs represent a rare entity in clinical medicine and literature regarding their management is limited. We report two cases which illustrate such complications arising from undiagnosed CPFs on the aortic valve. We further stress on the importance of identifying CPFs early so that they can be managed appropriately based on recommendations from the available literature. | Srikanth Yandrapalli Bella Mehta Pratik Mondal Tanush Gupta Pallavi Khattar John Fallon Randy Goldberg Sachin Sule Wilbert S Aronow | 2017 | World Journal of Clinical Cases2017，5，1： | 2 |
| 5 | Editorial on hemoglobin A1c, blood pressure, and lowdensity lipoprotein cholesterol goals in diabetics显示文摘The American Diabetes Association (ADA) 2013 guidelines state that a reasonable hemoglobin A1c goal for many nonpregnant adults with diabetes is less than 7.0% a hemoglobin A1c level of less than 6.5% may be considered in adults with short duration of diabetes, long life expectancy, and no significant cardiovascular disease if this can be achieved without significant hypoglycemia or other adverse effects of treatment. A hemoglobin A1c level less than 8.0% may be appropriate for patients with a history of severe hypoglycemia, limited life expectancy, advanced macrovascular and microvascular complications, extensive comorbidities, and long-standing diabetes in whom the hemoglobin A1c goal is difficult to attain despite multiple glucoselowering drugs including insulin. The ADA 2013 guidelines recommend that the systolic blood pressure in most diabetics with hypertension should be reduced to less than 140 mmHg. These guidelines also recommend use of an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in the treatment of hypertension in diabetics unless they are pregnant. Diabetics at high risk for cardiovascular events should have theirserum low-density lipoprotein (LDL) cholesterol lowered to less than 70 mg/dL with statins. Lower-risk diabetics should have their serum LDL cholesterol reduced to less than 100 mg/dL. Combination therapy of a statin with either a fibrate or niacin has not been shown to provide additional cardiovascular benefit above statin therapy alone and is not recommended. Hypertriglyceridemia should be treated with dietary and lifestyle changes. Severe hypertriglyceridemia should be treated with drug therapy to reduce the risk of acute pancreatitis. | Wilbert S Aronow | 2013 | World Journal of Cardiology2013，5，5： | 2 |
| 6 | Effects of Digoxin on Morbidity and Mortality in Diastolic Heart Failure: The Ancillary Digitalis Investigation Group Trial显示文摘 | Ali Ahmed Michael W. Rich Jerome L. Fleg Michael R. Zile James B. Young Dalane W. Kitzman Thomas E. Love Wilbert S. Aronow Kirkwood F. Adams Mihai Gheorghiade | 2006 | Circulation2006，，5： | 2 |
| 7 | Relation of microalbuminuria and coronary artery disease in patients with and without diabetes mellitus显示文摘 | Sukhija R Aronow WS Kakar P | 2006 | Am J Cardiol2006，98，3： | 1 |
| 8 | A randomized controlled trial of exercise to improve outcomes of acute hospitalization in older adults显示文摘 | Siebens H Aronow H Edwards D | 2000 | J Am Geriatr Soc2000，48，12： | 1 |
| 9 | Prevalence of valve calcium and association of valve calcium with coronary artery disease, atherosclerotic vascular disease, and all-cause mortality in 137 patients undergoing he- modialysis for chronic renal failure显示文摘 | Varma R Aronow WS MeClung JA | 2009 | Am J Cardiol2009，95，： | 1 |
| 10 | Genomic response of the brain to ischemic stroke, intracerebral hacmorrhage, kalnite seizures, hypoglycemia, and hypoglycemia, and hypoxia显示文摘 | Tang Y Lu A Aronow BJ | 2002 | Eur J Neu- rosci2002，15，12： | 1 |
| 11 | Ten most important things to learnfrom the ACCF/AHA 2011expert consenus documenton hypertension in the elderly显示文摘 | Aronow WS Banch M | 2012 | Blood pressure2012，21，1： | 1 |
| 12 | Usefulness of echocardiographic left ventricular hypertrophy, ventricular tachy-cardia and complex ventricular arrhythmias in predicting ventricu-lar fibrillation or sudden cardiac death in elderly patients显示文摘 | Aronow WS Epstein S Koenigsberg M | 1988 | Am J Cardiol1988，62，16： | 1 |
| 13 | Incidence of new coronary events in older persons with prior myocardial infarction and systemic hypertension treated with beta block- ers, angiotensin-converting enzyme inhibitors, diuretics, calcium antagonists, and alpha blockers 显示文摘 | Aronow WS Ahn C | 2002 | Am J Cardiol2002，89，10： | 1 |
| 14 | Factors that promote progressive development of the osteobiast phcrlotype in cultured htal rat ealvaria cells显示文摘 | Aronow MA Gerstenfeld LC Owen TA | 1990 | J Cell Physiol1990，143，2： | 1 |
| 15 | Association of average heart ratwe on 24-hour ambulatory electrocardiograms with incidence of new coronary events at 48-month follow-up in 1311 patients with heart disease and sinus rhypthm显示文摘 | Aronow WS Ahn C Merceando AD | 1996 | Am J Cardiol1996，78，： | 1 |
| 16 | Epidemiology,pathophysiology,prognosis and treatment of systolic and diastolic heart failure in elderly patients显示文摘 | Aronow WS | 2003 | Heart Dis2003，5，4： | 1 |
| 17 | Relation of cardiac troponin I levels with in-hospital mortality in patients with ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage 显示文摘 | Sandhu R Aronow WS Rajdev A | 2008 | Am J Cardiol2008，102，5： | 1 |
| 18 | GUDMAP :the genitourinary developmental molecular anatomy project显示文摘 | McMahon A P Aronow B J Davidson D R | 2008 | Journal of the American Society of Nephrolov2008，19，4： | 1 |
| 19 | Treatment of hypertension in the elderly显示文摘 | Aronow WS | 2008 | Compr Ther2008，34，34： | 1 |
| 20 | Management of peripheral arterial disease显示文摘 | ARONOW W S | 2005 | Cardiol Rev2005，13，2： | 1 |
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