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| 1 | Angiographic evaluation and management of acute gastrointestinal hemorrhage显示文摘Although most cases of acute nonvariceal gastrointestinal hemorrhage either spontaneously resolve or respond to medical management or endoscopic treatment,there are still a significant number of patients who require emergency angiography and transcatheter treatment.Evaluation with noninvasive imaging such as nuclear scintigraphy or computed tomography may localize the bleeding source and/or confirm active hemorrhage prior to angiography.Any angiographic evaluation should begin with selective catheterization of the artery supplying the most likely site of bleeding,as determined by the available clinical,endoscopic and imaging data.If a hemorrhage source is identified,superselective catheterization followed by transcatheter microcoil embolization is usually the most effective means of successfully controlling hemorrhage while minimizing potential complications.This is now wellrecognized as a viable and safe alternative to emergency surgery.In selected situations transcatheter intra-arterial infusion of vasopressin may also be useful in controlling acute gastrointestinal bleeding.One must be aware of the various side effects and potential complications associated with this treatment,however,and recognize the high re-bleeding rate.In this article we review the current role of angiography,transcatheter arterial embolization and infusion therapy in the evaluation and management of nonvariceal gastrointestinal hemorrhage. | T Gregory Walker Gloria M Salazar Arthur C Waltman | 2012 | World Journal of Gastroenterology2012，18，11： | 24 |
| 2 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 3 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 4 | Comparative Study of Artificial Neural Networks and Multiple Regression Analysis for Predicting Hoisting Times of Tower Cranes显示文摘 | Arthur W T Leung C M Tam D K Liu | 2000 | Building and Environment2000，36，4： | 1 |
| 5 | History of water- column anoxia in the Black Sea indicated by pyrite framboids size distributions显示文摘 | WILKIN R T ARTHUR M A DEAN W E | 1997 | Earth and Planetary Science Letters1997，148，34： | 1 |
| 6 | MammoSite and interstitial brachytherapy for accelerated partial breast irradiation: factors that affect toxicity and cosmesis 显示文摘 | SHAH N M TENENHOLZ T ARTHUR D | 2004 | Cancer2004，101，4： | 1 |
| 7 | Stable isotopes of oxygen and carbon and their application to sedimentologic and paleoenvironmental problems显示文摘 | ANDERSON T F ARTHUR M A | 1983 | SEPM Short Course1983，10，： | 1 |
| 8 | Transmission E- lectron Microscopy Characterization of Zircaloy-4 and ZIR- LOTM Oxide Layers显示文摘 | BENOIT de G ARTHUR T M WANG K | 2015 | Journal of Nuclear Materials2015，456，： | 1 |
| 9 | Structure and properties of poly (γ-benzyl-L-glutamate)cast from dimethylformamide显示文摘 | Alan J M Arthur V T | 1968 | The Journal of Physical Chemistry1968，72，4： | 1 |
| 10 | Wetlands for wastewater treatment: opportunities and limitations 显示文摘 | VERHOEVEN JOS T A MEULEMAN ARTHUR F M | 1999 | Ecological Engineering1999，12，12： | 1 |
| 11 | History of water-column an- oxia in the Black sea indicated by pyrite Framboid size distribu- tions 显示文摘 | Wilkin R T Arthur M A Dean W E | 1997 | Earth and Planetary Science Letters1997，148，34： | 1 |
| 12 | Interventions to reduce/eliminate Escherichia coli 0157:H7 in groundbeef显示文摘 | KOOHMARAIE M ARTHUR T M BOSILEVAC J M | 2007 | Meat Science2007，77，： | 1 |
| 13 | The national basin delineation project显示文摘 | Arthur A T Cox G M Kuhnert N R | | 0，，： | 1 |
| 14 | Oxidative stress as a therapeutic target during muscle wasting: considering the complex interactions显示文摘 | Arthur P G Grounds M D Shavlakadze T | 2008 | Curr Opin Clin Nutr Metab Care2008，11，4： | 1 |
| 15 | Bias-stress induced threshold voltage and drain current instability in 4H-SiC DMOSFETs显示文摘 | T Okayama S Arthur J Garrett M Rao | 2008 | Solid-State Electronics2008，52，1： | 1 |
| 16 | Verification of workflow task structures: A petri-net-based approach 显示文摘 | Vander Aslst W M P Arthur H M Hofstede T | 2000 | Information Systems2000，25，1： | 1 |
| 17 | Wetlands for wastewater treatment: opportunities and limitations显示文摘 | Jos T A Verhoeven Arthur F M Meuleman | 1999 | Ecological Engineering1999，12，： | 1 |
| 18 | Wetlands for wastewater treatment : Opportunities and limitations 显示文摘 | Jos T A Verhoeven Arthur F M Meuleman | 1999 | Ecol Eng1999，12，12： | 1 |
| 19 | Evaluation of culture and PCR based detection methods for Escherichia coli O157:H7 in inoculated ground beef显示文摘 | ARTHUR T M BOSILEVAC J M NOU X | 2005 | J Food Prot2005，68，8： | 1 |
| 20 | Scenic Assessment: An Overview显示文摘 | Arthur L M Daniel T C Boster R S | 1977 | Landscape Planning1977，，4： | 1 |
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